A5101805946- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- RNA Research and Splicing
- Water Systems and Optimization
- Muscle Physiology and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Urban Stormwater Management Solutions
- Maritime Navigation and Safety
- RNA regulation and disease
- Water resources management and optimization
Iscte – Instituto Universitário de Lisboa
2024
University of Lisbon
2024
University of Coimbra
2008-2019
National Laboratory for Civil Engineering
2008
Polytechnic Institute of Coimbra
2008
Abstract Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects BDNF depend on activation translation activity, which requires delivery transcripts to synapse. In this work, we found that neuronal activity regulates dendritic localization RNA-binding protein heterogeneous nuclear ribonucleoprotein K (hnRNP K) cultured rat hippocampal neurons by stimulating BDNF-Trk signaling. Microarray experiments...
The RNA binding protein hnRNP K mediates BDNF-induced proteome remodeling at the neuronal synapse.
The wastewater generated in urban areas is one of the main sources water pollution, particularly regions characterized with large population density and high urbanization degree. In this paper, we present an optimization model for regional systems planning. aimed at helping to determine best possible configuration (layout sewer networks, location treatment plants, etc.) system a region taking economic, environmental, technical criteria explicitly into account. It can be used separately, or...
Dendritic protein synthesis plays a critical role in several forms of synaptic plasticity, including BDNF (brain-derived neurotrophic factor)-mediated long-term potentiation (LTP). transcripts are typically transported repressed state as components large ribonucleoprotein complexes, and then translated upon stimulation at, or the vicinity, activated synapses. Heterogeneous nuclear A2/B1 (hnRNP A2/B1) is trans-acting factor involved dendritic mRNA trafficking, but how distribution dendrites...