A5025013805- Gastrointestinal motility and disorders
- Music Therapy and Health
- Diet and metabolism studies
- MicroRNA in disease regulation
- RNA Research and Splicing
- Neuroscience and Music Perception
- Gut microbiota and health
- Circular RNAs in diseases
- Infant Health and Development
- Child Nutrition and Feeding Issues
- Pelvic floor disorders treatments
- Therapeutic Uses of Natural Elements
- Psychosomatic Disorders and Their Treatments
- Advanced Memory and Neural Computing
- Eating Disorders and Behaviors
- Nerve injury and regeneration
- Intensive Care Unit Cognitive Disorders
- Sleep and related disorders
- Mobile Health and mHealth Applications
- Neuroscience and Neuropharmacology Research
- Muscle Physiology and Disorders
- Lysosomal Storage Disorders Research
- Gastroesophageal reflux and treatments
Haukeland University Hospital
2020-2025
University of Bergen
2012-2025
KU Leuven
2023
Universitat de Barcelona
2012
Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types experience-dependent synaptic plasticity and long-term memory in mammals. However, the mechanisms governing Arc-specific translation are little understood. Here, we asked whether Arc regulated by microRNAs. Bioinformatic analysis predicted numerous candidate miRNA binding sites within 3'-untranslated region (UTR). Transfection corresponding microRNAs human embryonic kidney cells inhibited...
Abstract Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects BDNF depend on activation translation activity, which requires delivery transcripts to synapse. In this work, we found that neuronal activity regulates dendritic localization RNA-binding protein heterogeneous nuclear ribonucleoprotein K (hnRNP K) cultured rat hippocampal neurons by stimulating BDNF-Trk signaling. Microarray experiments...
Background/Objectives: Irritable bowel syndrome (IBS) is a gut-brain disorder characterized by abdominal pain, altered habits, and psychological distress. While brain-gut interactions are recognized in IBS pathophysiology, the relationship between brain morphometry, cognitive function, clinical features remains poorly understood. The study aims to conduct following: (i) replicate previous univariate morphometric findings patients software comparisons; (ii) investigate whether multivariate...
Abstract Background Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there a need for better diagnostic understanding the condition. Objective In this wireless motility capsule study, we aimed investigate gastrointestinal transit and contractility in diabetes with without constipation, healthy controls. Methods We prospectively included type 1 or 2 symptoms....
Abstract Background A low FODMAP diet (LFD) is an established dietary treatment for patients with irritable bowel syndrome (IBS). However, knowledge on the extended effects of restriction phase regarding nutrient intake, symptom severity, and quality life (QoL) sparse. Therefore, our objectives were to evaluate safety a dietitian‐led 12‐week strict LFD measures blood biochemistry, nutritional status, QoL. Methods In this open‐label intervention IBS predominantly diarrhea or mixed stool...
The relationship between gut microbiota and irritable bowel syndrome (IBS) subtype is unclear. We aimed to explore whether differences in fecal bacteria composition short-chain fatty acid (SCFA) levels were associated with subtypes symptoms of IBS.
Abstract Purpose Irritable bowel syndrome (IBS) is a diagnosis defined by gastrointestinal (GI) symptoms like abdominal pain and changes associated with defecation. The condition classified as disorder of the gut-brain interaction (DGBI), patients IBS commonly experience psychological distress. present study focuses on this distress, from reports fatigue, anxiety, depression, sleep disturbances, performance cognitive tests. aim was to investigate joint contribution these features distress in...
Gastrointestinal (GI) symptoms appear frequently in patients with anorexia nervosa (AN), but the associations between psychopathological, GI, and eating disorder (ED) remain unclear. This study aimed to determine relationships of GI complaints psychopathological measures, ED symptoms, body mass index (BMI) AN.Thirty outpatients AN aged >16 years were included. Psychopathological measures (Symptom Checklist-90-Revised, Beck Depression Inventory-II, Anxiety Inventory), (Eating Disorder...
Introduction: Irritable bowel syndrome (IBS) is characterized as a disorder of the gut-brain interaction (DGBI). Here, we explored presence problems related to executive function (EF) in patients with IBS and tested relative importance cognitive features involved EF. Methods: A total 44 22 healthy controls (HCs) completed Behavior Rating Inventory Executive Function (BRIEF-A), used identify nine EF features. The PyCaret 3.0 machine-learning library Python was explore data, generate robust...
microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A goal is to identify changes miRNA expression underlying synthesis-dependent forms synaptic plasticity such as long-term potentiation (LTP). Previous analyses focused on levels total lysate samples. Here, we asked whether accurately reflect amount bound Argonaute within miRNA-induced silencing complex (miRISC). Ago2 immunoprecipitation was used isolate RISC-associated miRNAs following high-frequency stimulation...
Irritable bowel syndrome (IBS) is a common clinical label for medically unexplained gastrointestinal (GI) symptoms, recently described as disturbance of the brain-gut-microbiota (BGM) axis. To gain better understanding mechanisms underlying poorly understood etiology IBS, we have designed multifaceted study that aim to stratify complex interaction and dysfunction between brain, gut, microbiota in patients with IBS.Deep phenotyping data from IBS (n = 100) healthy age- (between 18 65)...
Objective To investigate cognitive function in patients with irritable bowel syndrome (IBS) and its relation to anxiety/depression severity of gastrointestinal (GI) symptoms.
Abstract Background Irritable bowel syndrome (IBS) has a high worldwide prevalence and there are few effective treatment options. Patient education can influence patient behavior that subsequently may lead to changes in attitudes skills necessary for maintenance or improvement management of symptom severity quality life. However, as postdiagnostic be resource demanding, assessment digital approaches verification their effectiveness is warranted. Objective This cohort study aimed investigate...
Background/Objectives: Irritable bowel syndrome (IBS) is a gut-brain disorder characterized by abdominal pain, altered habits, and psychological distress. While brain-gut interactions are recognized in IBS pathophysiology, the relationship between brain morphometry, cognitive function, clinical features remains poorly understood. The study aims to (i) replicate previous univariate morphometric findings patients conduct software comparisons; (ii) investigate whether multivariate analysis of...
Background: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain associated with alterations in stool form and/or frequency. Co-morbidities such as anxiety, depression, fatigue, and insomnia are frequently reported patients suffering from IBS. Identification of these symptoms should thus be an integral part IBS assessment. However, optimal tool to screen for core psychological still missing. Here, we aim develop symptom...
<sec> <title>BACKGROUND</title> Patient education can influence patient behavior that subsequently may lead to changes in attitudes and skills necessary for maintenance or improvement management of symptom severity quality life. </sec> <title>OBJECTIVE</title> In this randomized study, we have investigated the effects a digital eHealth program on domains severity, life, anxiety depression, measure general client satisfaction, compared physical school, cohort 256 patients with irritable bowel...