A5068535751- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Axon Guidance and Neuronal Signaling
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Sphingolipid Metabolism and Signaling
- Nerve Injury and Rehabilitation
- Neurological Disorders and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Spine and Intervertebral Disc Pathology
- Aluminum toxicity and tolerance in plants and animals
- Magnesium in Health and Disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Nuclear Receptors and Signaling
- Bone and Joint Diseases
- Spinal Dysraphism and Malformations
- Genetics and Neurodevelopmental Disorders
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease and Spinal Disorders
- Epigenetics and DNA Methylation
- Animal Behavior and Welfare Studies
- Lipid Membrane Structure and Behavior
- Pluripotent Stem Cells Research
- Neuroblastoma Research and Treatments
- Mesenchymal stem cell research
University of Zurich
1998-2018
Salk Institute for Biological Studies
2001-2012
ETH Zurich
2001-2008
École Polytechnique Fédérale de Lausanne
2008
Novartis (Switzerland)
2007
Christopher and Dana Reeve Foundation
2004
After a lesion of the mature CNS, structural plasticity and functional recovery are very limited, in contrast to developing CNS. The postnatal decrease is correlated time with formation myelin. To investigate possible role an important myelin-associated neurite growth inhibitor (NI-250; IN-1 antigen), one pyramidal tract adult Lewis rats was lesioned (pyramidotomy), were treated antibody IN-1, control antibody, or no antibody. Functional studied from postoperative day 14 until 42 using food...
Smaller spinal cord injuries often allow some degree of spontaneous behavioral improvements because structural rearrangements within different descending fiber tracts or intraspinal circuits. In this study, we investigate whether rehabilitative training the forelimb (forced limb use) influences recovery and plastic events after injury to a defined tract, corticospinal tract (CST). Female adult Lewis rats received unilateral CST at brainstem level. Use contralateral impaired was either...
Fine finger and hand movements in humans, monkeys, rats are under the direct control of corticospinal tract (CST). CST lesions lead to severe, long-term deficits precision movements. We transected completely both CSTs adult treated animals for 2 weeks with an antibody that neutralized central nervous system neurite growth inhibitory protein Nogo-A (mAb IN-1). Anatomical studies rubrospinal tracts showed number collaterals innervating cervical spinal cord doubled mAb IN-1- but not...
Abstract Sphingosine‐1‐phosphate (S1P) receptors are widely expressed in the central nervous system where they thought to regulate glia cell function. The phosphorylated version of fingolimod/FTY720 (FTY720P) is active on a broad spectrum S1P and parent compound currently phase III clinical trials for treatment multiple sclerosis. Here, we aimed identify which type(s) receptor(s) targeted by FTY720P. Using calcium imaging mixed cultures from embryonic rat cortex show that astrocytes major...
Although Nogo-A has been intensively studied for its inhibitory effect on axonal regeneration in the adult central nervous system, little is known about function during brain development. In embryonic mouse cortex, expressed by radial precursor/glial cells and tangentially migrating as well postmigratory neurons. We radially neuroblasts wild-type knockout (KO) embryos. vitro analysis showed that receptor components NgR, Lingo-1, TROY, p75 are emigrating from forebrain–derived neurospheres....
Adult MRL/MpJ mice have been shown to possess unique regeneration capabilities. They are able heal an ear-punched hole or injured heart with normal tissue architecture and without scar formation. Here we present functional histological evidence for enhanced recovery following spinal cord injury (SCI) in mice. A control group (C57BL/6 mice) underwent a dorsal hemisection at T9 (thoracic vertebra 9). Our data show that recovered motor function significantly faster more completely. We observed...
Abstract Myelin contains potent inhibitors of neurite growth which have been implicated in the failure long‐distance regeneration nerve fibres within CNS. These myelin‐associated may also be involved stabilization neural connections by suppressing sprouting and fibre growth. After lesions CNS neonatal animals, extensive rearrangements remaining systems observed. In rat, this plasticity neuronal is severely restricted following first few weeks postnatal life, coincident with progression...
After a selective unilateral lesion of the corticospinal tract (CST) at level brainstem (pyramidotomy) and neutralization myelin associated neurite growth inhibitors NI-35/250 with monoclonal antibody (mAb) IN-1, we had previously observed strong behavioural recovery in parallel an enhanced structural plasticity lesioned as well unlesioned CST. The present study focuses on regenerative response cut CST axons site these adult rats. results show enhancement sprouting fibres by treatment mAb...
If damage to the central nervous system (CNS) occurs early in life, extensive rearrangements of remaining fiber systems as well regeneration lesioned fibers take place. In rat or hamster, newly grown projections have been described only if lesion occurred within first two weeks postnatally. This decreasing growth ability correlates with CNS maturation and progression myelination. Myelin contains potent neurite inhibitors NI-35/250 that are crucially involved failure long-distance lack...
Abstract Regeneration and compensatory sprouting are limited after lesions in the mature mammalian central nervous system contrast to developing (CNS). After neutralization of growth inhibitor Nogo‐A, however, massive rearrangements fiber connections occurred unilateral pyramidal tract adult rats: Corticofugal fibers from lesioned side crossed midline brainstem innervated contralateral basilar pontine nuclei. To determine whether these newly sprouted formed synaptic contacts, we analyzed...