A5033102845- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Spinal Cord Injury Research
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Spinal Dysraphism and Malformations
- Acute Myeloid Leukemia Research
- Nerve injury and regeneration
- vaccines and immunoinformatics approaches
- Microtubule and mitosis dynamics
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
AC Immune (Switzerland)
2024
ETH Zurich
2008-2020
École Polytechnique Fédérale de Lausanne
2010
University of Zurich
2008-2009
Understanding peptide presentation by specific MHC alleles is fundamental for controlling physiological functions of T cells and harnessing them therapeutic use. However, commonly used in silico predictions mass spectroscopy have their limitations precision, sensitivity, throughput, particularly class II. Here, we present MEDi, a novel mammalian epitope display that allows an unbiased, affordable, high-resolution mapping capacity. Our platform provides detailed picture testing every...
Abstract Glioblastomas (GB) are aggressive primary brain tumors. Helix-loop-helix (HLH, ID proteins) and basic HLH (bHLH, e.g., Olig2) proteins transcription factors that regulate stem cell proliferation differentiation throughout development into adulthood. Their convergence on many oncogenic signaling pathways combined with the observation their overexpression in GB correlates poor clinical outcome identifies these as promising therapeutic targets. Important dimerization partners of...
<title>Abstract</title> Effective anti-tumor immunity is largely driven by cytotoxic CD8<sup>+</sup> T cells that can specifically recognize tumor antigens. However, the factors which ultimately dictate successful rejection remain poorly understood. Here we identify a subpopulation of are antigen-specific in patients with melanoma but resemble KIR<sup>+</sup>CD8<sup>+</sup> regulatory function (Tregs). These detectable both and blood, higher levels this population associated worse overall...
Abstract αβT-cell receptors (TCRs) bind peptide-major histocompatibility complexes (pMHC) with low affinity, posing a considerable challenge for direct identification of cognate peptides (epitopes). Here, we describe platform the discovery MHC class-II presented epitopes, based on screening engineered reporter cells expressing novel pMHC-TCR (MCR) hybrid molecules carrying cDNA-derived peptides. This technology identifies natural epitopes CD4 T-cells in an unbiased and efficient manner...
Abstract PRIME IL-15 (RPTR-147) is a novel non-genetically modified, autologous, multi-clonal T cell product loaded with an IL-15Fc nanogel. The derived from peripheral cells that are primed and expanded against five tumor associated antigens (TAAs) known to be overexpressed in multiple different types: PRAME, NY-ESO, SSX-2, WT-1 Survivin. 17 patients advanced or metastatic solid-tumor cancers were dosed Phase I dose escalation study. Where samples available, we characterized the reactivity...