A5043681397- Platelet Disorders and Treatments
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Nanoparticles: synthesis and applications
- Blood properties and coagulation
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Biochemical Acid Research Studies
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Macrophage Migration Inhibitory Factor
- Inflammatory Biomarkers in Disease Prognosis
- Vitamin C and Antioxidants Research
- Cancer, Lipids, and Metabolism
Gdańsk Medical University
2019-2022
We studied the effects of silver nanoparticles (AgNPs) on human blood platelet function. hypothesized that AgNPs, a known antimicrobial agent, can be used as blood-compatible, "ideal material'' in medical devices or drug delivery system. Therefore, aim current study was to investigate if functionalized AgNPs affect function and platelets well endothelial cell viability vitro.AgNPs, with reduced glutathione (GSH), polyethylene glycol (PEG) lipoic acid (LA) were synthesized. Quartz crystal...
Purpose: To study and compare the antibacterial properties potential cytotoxic effects of commercially available uncoated silver nanoparticles (AgNPs) with lipoic acid coated (AgNPsLA) developed by our group. The antibacterial, cytotoxic, hemolytic those NPs were assessed main objective investigating if AgNPsLA could maintain their while improving biosafety profile over AgNPs within blood vessel's microenvironment. Methods: Comercially 2.6 nm 2.5 synthesized characterized as previously...
In the search for new drug delivery platforms cardiovascular diseases and coating of medical devices, we synthesized eptifibatide-functionalized silver nanoparticles (AgNPs-EPI) examined pharmacological activity AgNPs-EPI on platelets endothelial cells in vitro ex vivo.Spherical AgNPs linked to eptifibatide were characterized. Cytotoxicity was measured microvascular (HMEC-1), red blood cells. Platelet mitochondrial respiration using Oxygraph-2k, a high-resolution modular respirometry system....