A5069704555- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal Transplantation Outcomes and Treatments
- Urological Disorders and Treatments
- Metastasis and carcinoma case studies
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Heavy Metal Exposure and Toxicity
- Organ Donation and Transplantation
- Eicosanoids and Hypertension Pharmacology
- Bacterial Identification and Susceptibility Testing
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Natural Antidiabetic Agents Studies
- Acute Kidney Injury Research
- Liver physiology and pathology
- Hematopoietic Stem Cell Transplantation
- Antioxidant Activity and Oxidative Stress
- Renal Diseases and Glomerulopathies
- Cancer-related gene regulation
- Chemotherapy-induced organ toxicity mitigation
Mansoura University
2015-2025
University of Sharjah
2023
Houston Methodist
2021
Methodist Hospital
2021
Cornell University
2021
Mansoura University Hospital
2018
Harvesting, expansion, and directed differentiation of human bone marrow-derived mesenchymal stem cells (BM-MSCs) could provide an autologous source surrogate β-cells that would alleviate the limitations availability and/or allogenic rejection following pancreatic or islet transplantation. Bone marrow were obtained from three adult type 2 diabetic volunteers nondiabetic donors. After 3 days in culture, adherent MSCs expanded for two passages. At passage 3, was carried out a three-staged...
Development of late uro-intestinal malignancy after bowel incorporation into the urinary tract is a constant long-term hazard, even in absence fecal material. We report 6 such cases.A total 350 patients treated with an ileal conduit, 260 replacement ureter and 55 ileocystoplasty were evaluated followed for minimum 4 years. The methods evaluation included urine analysis microscopic hematuria, culture, serum creatinine abdominal ultrasonography. These evaluations performed every 2 months...
The non-steroidal anti-inflammatory drug tolfenamic acid (TA) inhibits proliferation of SEG-1 and BIC-1 esophageal cancer cells with half-maximal growth inhibitory concentration values 36 48 μM, respectively. TA also increased Annexin V staining in both cell lines, indicative proapoptotic activity. Treatment for up to 72 h decreased expression specificity protein (Sp) transcription factors Sp1, Sp3 Sp4 this was accompanied by the well-characterized Sp-regulated genes cyclin D1, vascular...
Abstract Background Obstructive left main disease (LMD) is a challenging entity of coronary artery with variable patterns among different studies. We aimed to evaluate the prevalence, demographic, clinical, and angiographic profiles LMD. conducted single-center retrospective study over period 10 years screen all patients who underwent elective cardiac catheterization for chronic syndrome. Of 19,336 screened cases, 944 obstructive LMD were included as patients' group. Age sex-matched control...
The B-cell translocation gene 2 (BTG2) is considered to act as a tumour-suppressor because of its antiproliferative and antimigratory activities. Higher levels BTG2 expression in tumour cells have been linked better clinical outcome for several cancer entities. Here, we investigated the function bladder cancer. was silenced by RNA interference. Cell motility wound healing Boyden chamber assays. protein studied immunohistochemistry. We observed that targeted suppression interference did not...
noAccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2004Local Urethral Recurrence After Radical Cystectomy and Orthotopic Bladder Substitution in Women:: A Prospective Study BEDEIR ALI-EL-DEIN, MOHAMED ABDEL-LATIF, ALBAIR ASHAMALLAH, MONA ABDEL-RAHIM, A. GHONEIM ALI-EL-DEINBEDEIR ALI-EL-DEIN , ABDEL-LATIFMOHAMED ABDEL-LATIF ASHAMALLAHALBAIR ASHAMALLAH ABDEL-RAHIMMONA ABDEL-RAHIM GHONEIMMOHAMED...
This study was undertaken to examine the effects of montelukast (MNT) on lung and kidney injury in lipopolysaccharide (LPS) induced systemic inflammatory response. Rats were randomized into 5 groups (n = 8 rats/group): (i) Control; (ii) LPS treated (10 mg/kg body mass, by intraperitoneal (i.p.) injection); (iii) + MNT mg/kg, per oral (p.o.)); (iv) (20 p.o); (v) dexamethasone (DEX; 1 i.p.). Twenty-four hours after sepsis induced, or kidney:body mass ratio percent survival rats determined....
The present study was designed to explore the possible protective effects of agmatine, a known nitric oxide (NO) synthase inhibitor, against gentamicin-induced nephrotoxicity in rats. For this purpose, we quantitatively evaluated renal structural and functional alterations using histopathological biochemical approaches. Furthermore, effect agmatine on hypersensitivity urinary bladder rings acetylcholine (ACh) evaluated. Twenty-four male Wistar albino rats were randomly divided into 3 groups,...
In this study, we studied the effect of lipopolysaccharide from Rhodobacter sphaeroides (LPS-RS), an inhibitor Toll-like receptor 4 (TLR4), in LPS-induced acute lung injury (ALI). Male Sprague–Dawley rats were treated with LPS-RS (0.1 mg/kg body mass, by intraperitoneal (i.p.) injection) 1 h before LPS injection (10 mg/kg, i.p.). Bronchoalveolar lavage fluid (BALF) and tissues collected 24 later to determine total differential cell count, protein content, levels lactate dehydrogenase (LDH),...
Abstract Hepatic damage is one of the most common complications related to cisplatin (Cis) use. Recently, liver protection lines are being discovered avoid hepatic cell death as a result oxidative, inflammatory, and apoptotic disturbance. Limited data reported hepatoprotective effect vinpocetine (Vin) in acute injury models. This study was designed determine potential protective Vin (10‐30 mg/kg, orally) against Cis‐induced (10 IP) mice. administration for 1 week before Cis injection until...
Epidermal growth factor receptor (EGFR) overexpression is believed to be associated with bladder cancer (BC) progression and poor clinical outcomes. In vivo studies have linked EGFR subcellular trafficking chemo-resistance cisplatin-based chemotherapies. This has not been studied in the adjuvant setting. We aimed investigate prognostic significance of expression patients receiving chemotherapy following radical cystectomy for advanced BC. The database from Urology Nephrology Center at...
The present study aimed to determine the possible beneficial effects of dimethyl fumarate (DMF) against oxidative stress and inflammation in hypercholesterolemic rabbits. Twenty four New Zealand male rabbits were randomly allocated into 4 groups as following: Group I (control): received standard rabbit chow; II high cholesterol diet (HCD): 1% cholesterol-enriched chow for weeks; III (HCD-DMF): administered DMF (12.5 mg/kg/day, orally) IV (DMF): plus weeks. At end experiment (day 30), blood...
Purpose: To identify the role of a set microRNAs and their target genes protein expression levels in pathogenesis bladder cancer with muscular invasion (T2−T4) non-muscular (T1). Methods: In 157 patients, specimen was examined for miRNAs including let-7a-5p, miRNA-449a-5p, miRNA-145-3P, miRNA-124-3P, miRNA-138-5p, miRNA-23a-5p targeted genes; β-catenin, WNT7A, IRS2, FZD4, SOS1, HDAC1, HDAC2, HIF1α, PTEN using qRT-PCR technique. The prognostic effect on cancer-specific survival (CSS)...
SUMMARY: Background: Cardiovascular events are markedly increased in systemic lupus erythematosus (SLE) and the mechanism of atherogenesis remains poorly understood. Low‐grade inflammation endothelial dysfunction play pivotal roles initiation, progression propagation atherosclerotic process. Several methods have been employed to assess function, among them measurement biomarkers activation (intercellular adhesion molecule (ICAM)‐1). Since then, it has reported that such a more important role...