A5004539584- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Natural Antidiabetic Agents Studies
- Platelet Disorders and Treatments
- Phytochemicals and Antioxidant Activities
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Inflammatory Bowel Disease
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Imaging and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Antimicrobial Peptides and Activities
- Diet and metabolism studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Flavonoids in Medical Research
- Nonmelanoma Skin Cancer Studies
- Blood properties and coagulation
- Adipose Tissue and Metabolism
Grigore T. Popa University of Medicine and Pharmacy
2016-2025
The fruits of Aronia melanocarpa Elliot (Rosaceae), (black chokeberry), and Sambucus nigra L. (Caprifoliaceae), elderberries are rich in anthocyanins. Many studies have reported that anthocyanins beneficial diabetes due to their capacity stimulate insulin secretion reduce oxidative stress.The purpose this study is prove the biologically active properties polyphenols extracted from S. A. fruit. also details influence plant on immune system imbalances within mellitus.Polyphenolic extract was...
The aim of this study is to characterize the content Aronia melanocarpa Elliott (black chokeberry) extract and also estimate influence polyphenolic compounds contained in chokeberries on oxidative stress, an L-NAME-induced experimental model arterial hypertension. rat blood pressure values were recorded using a CODA Noninvasive Blood Pressure System. HPLC/DAD coupled with ElectroSpray Ionization-Mass Spectrometry allowed identification five phenolic berries ethanolic as follows: chlorogenic...
The altered magnesium status in inflammatory bowel disease (IBD) patients may have a significant clinical imprint considering its role cell signaling and genomic stability, as well involvement IBD patients' fatigue. Our study pioneers the investigation of hair concentration patterns an adult population patients. is compared to healthy controls order identify correlations between relevant parameters related activity, psychological status, sleep quality. We report significantly lower within...
Background and Objectives: Total hip replacement total knee arthroplasty carry a high risk of postoperative venous thromboembolism (VTE); therefore, anticoagulation prophylaxis is recommended in these patients. Unfortunately, there are no guidelines about VTE patients with hemophilia who underwent high-risk surgeries. To determine whether have VTE, we conducted retrospective study on elective at our hospital 2016. Materials Methods: There were 11 A B Recombinant factor VIII or IX also active...
Gallbladder carcinoma (GBC) is one of the most aggressive malignancies biliary tract, often originating from chronic inflammation associated with gallstones and cholecystitis. Persistent plays a pivotal role in development preneoplastic changes, such as metaplasia, which may progress to malignancy. Despite its relatively low incidence, GBC characterized by poor prognosis due late-stage diagnosis, highlighting urgent need for improved early detection strategies. This study aimed assess...
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play crucial role in extracellular matrix (ECM) remodeling and implicated the pathogenesis various cardiovascular diseases (CVDs). Their dysregulation has been linked to atherosclerosis, myocardial infarction (MI), heart failure (HF), aortic stenosis, contributing vascular inflammation, plaque destabilization, adverse cardiac remodeling. Recent research highlights MMPs’ involvement beyond ECM degradation,...
Background: A healthy sleep–wake cycle is fundamental for regulating immune function. Sleepiness and fatigue are often manifestations of chronic inflammatory disorders, such as bowel disease (IBD), potentially influencing the course disease. Our aim was to characterize sleep impairment in patients with IBD identify potential associated factors. Methods: We conducted a single-center prospective case control study including controls. evaluated clinical biochemical parameters, through...
Gallbladder disorders encompass a spectrum from congenital anomalies to inflammatory and neoplastic conditions, frequently requiring surgical intervention. Epithelial abnormalities like adenoma metaplasia have the potential progress carcinoma, emphasizing importance of histopathological assessment for early detection malignancy. cancer (GBC) may be incidentally discovered during cholecystectomy presumed benign underscoring need thorough examination. However, lack clarity regarding molecular...
The effects of polyphenols extracted from Sambucus nigra fruit were studied in streptozotocin- (STZ-) induced hyperglycemic rats to evaluate its possible antioxidant, anti-inflammatory, antiglycosylation activity, and antiosteoporosis diabetes. DEXA bone mineral density tests performed order determine (BMD), content (BMC), fat (%Fat) control diabetic animals, before after polyphenol delivery. As compared the normoglycemic group, treated with STZ (60 mg/kg body weight) revealed a significant...
Cardiovascular diseases, among which includes coronary artery disease, represent one of the most important causes mortality and morbidity worldwide. Research aimed at determining risk factors involved recognizes a group "traditional" factors, but also more recent studies identified over 100 "novel" ones may have role in disease. Among latter is thrombophilia profile patient, pathology well-established for its involvement venous thromboembolism, with less studied implications arterial...