A5036494635- Research on Leishmaniasis Studies
- Toxin Mechanisms and Immunotoxins
- Biochemical and Structural Characterization
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and biological activities of Ficus species
- Insect Pest Control Strategies
- Multiple Myeloma Research and Treatments
Secretaría de Investigación, Innovación y Educación Superior
2021-2022
Pentavalent antimonials are the first-line treatment for localized cutaneous leishmaniasis. However, they have disadvantages such as their elevated toxicity, high costs, and parenteral application. Plant-derived compounds may be an alternative against this disease. Previous in vitro studies shown that (3S)-16,17-didehydrofalcarinol (1), a polyacetylene oxylipin isolated from Tridax procumbens, is active Leishmania mexicana. We analyzed mechanism of action compound 1, evaluating reactive...
(3S)-16,17-Didehydrofalcarinol (1a) was isolated from the roots of Tridax procumbens in low amounts (0.0359 mg/g). Here, we report a novel synthesis route order to provide quantities necessary for vivo tests. For this purpose, two-synthons coupling applied. On one hand, (Z)-10-bromodeca-1,8-diene (10) nine steps obtained, and on other, hepta-1-en-4,6-diyn-3-ol (11) single step, fragments were coupled give racemic 1 27% yield. Finally, chiral chromatography resolution desired enantiomer 1a...