A5009931916- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Hip and Femur Fractures
- Innovations in Medical Education
- Heart Failure Treatment and Management
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cerebrovascular and Carotid Artery Diseases
- Hemodynamic Monitoring and Therapy
- Anesthesia and Pain Management
- Music Therapy and Health
- Frailty in Older Adults
- Clinical Reasoning and Diagnostic Skills
- Respiratory Support and Mechanisms
- Anatomy and Medical Technology
- Statistical Methods in Clinical Trials
- Spinal Hematomas and Complications
- Neurological and metabolic disorders
- Optical Imaging and Spectroscopy Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Surgical Simulation and Training
- Family and Patient Care in Intensive Care Units
Kantonsspital Graubünden
2012-2025
University Hospital of Basel
2005-2017
University of Basel
2011-2017
Kantonsspital Aarau
2015
Pain and Rehabilitation Medicine
2014
Christophorus Kliniken
2014
University Hospital of Lausanne
2011-2012
University of Lausanne
2011-2012
University of KwaZulu-Natal
2011
Objective: Cardiac surgery is frequently followed by postoperative delirium, which associated with increased 1-year mortality, late cognitive deficits, and higher costs. Currently, there are no recommendations for pharmacologic prevention of delirium. Impaired cholinergic transmission believed to play an important role in the development We tested hypothesis that prophylactic short-term administration oral rivastigmine, a cholinesterase inhibitor, reduces incidence delirium elderly patients...
BACKGROUND: Increasing evidence links postoperative cognitive dysfunction (POCD) to surgery and anesthesia. POCD is recognized as an important neuropsychological adverse outcome in surgical patients, particularly the elderly. This prospective cohort study aimed investigate whether associated with impaired intraoperative cerebral autoregulation oxygenation, increased levels of biomarkers brain injury. METHODS: Study subjects were patients ≥65 years age scheduled for major noncardiac surgery....
Abstract Background Intra- and postoperative adverse events are devastating to patients costly for healthcare systems. In 2008, the World Health Organization Surgical Safety Checklist was introduced minimise morbidity mortality enhance team performance. It consists of three parts whereof third part, sign-out at end surgery, is generally performed poorly. Addressing intraoperative discussion consecutive management should take place during this often-omitted sign-out. To address issue, a...
Cerebral cholinergic transmission plays a key role in cognitive function, and anticholinergic drugs administered during the perioperative phase are hypothetical cause of postoperative dysfunction (POCD). We hypothesized that increase serum activity (SAA) is associated with POCD elderly patients.Seventy-nine patients aged >65 years undergoing elective major surgery under standardized general anesthesia (thiopental, sevoflurane, fentanyl, atracurium) were investigated. Cognitive functions...
Background Data regarding immunomodulatory effects of parenteral n‐3 fatty acids in sepsis are conflicting. In this study, the effect administration on markers brain injury, incidence sepsis‐associated delirium, and inflammatory mediators septic patients was investigated. Methods Fifty with were randomized to receive either 2 ml/kg/day a lipid emulsion containing highly refined fish oil (equivalent 0.12 mg/kg/day) during 7 days after admission intensive care unit or standard treatment....
BACKGROUND The duration of neuromuscular block (NMB) following succinylcholine administration is characterised by a high interindividual variability. However, this has not yet been quantified in large sample surgical patients. significance underlying clinical factors unknown. OBJECTIVE objective study was to profile the variability NMB standard dose and investigate contributing genetic factors. DESIGN A prospective, observational study. SETTING Tertiary referral centre. PATIENTS In total...
We aimed to compare the minimum p value method and area under receiver operating characteristics (ROC) curve approach categorize continuous biomarkers for prediction of postoperative 30-day major adverse cardiac events in noncardiac vascular surgery patients. Individual-patient data from six cohorts reporting B-type natriuretic peptide (BNP) or N-terminal pro-B-type (NTproBNP) were obtained. These dichotomized using compared with previously reported ROC curve-derived thresholds logistic...
Postoperative cognitive dysfunction (POCD) refers to a postoperative decline in function compared with preoperative function. Diagnosis requires pre-and testing, the latter of which is usually performed both 7 days and 3 months postoperatively. Although several risk factors for POCD have been described, age only consistently reported factor. often transient. It may last months, associated leaving labor market prematurely increased mortality. As pathophysiology still matter debate likely be...
<i>Background/Aims:</i> Cognitive dysfunction after medical treatment is increasingly being recognized. Studies on this topic require repeated cognitive testing within a short time. However, with testing, practice effects must be expected. We quantified in demographically corrected summary score of neuropsychological test battery repeatedly administered to healthy elderly volunteers. <i>Methods:</i> The Consortium Establish Registry for Alzheimer’s Disease (CERAD)...
As competency-based curricula get increasing attention in postgraduate medical education, Entrustable Professional Activities (EPAs) are gaining popularity. The aim of this survey was to determine the use EPAs anesthesiology training programs across Europe and North America.A developed distributed residency program directors Switzerland, Germany, Austria, Netherlands, USA Canada. A convergent design mixed-methods approach used analyze both quantitative qualitative data.The response rate 38%...
The use of Bispectral Index (BIS) monitors for assessing depth sedation has led to a reduction in both the incidence awareness and anaesthetic consumption total intravenous anaesthesia. However, these are vulnerable artefacts. In addition processed number, raw frontal electroencephalogram (EEG) can be displayed as curve on same monitor. Anaesthesia practitioners learn interpret EEG short tutorial may quicker more accurate thanBIS anaesthesia by recognising patterns. We hypothesise that...
Graduate medical education is being reformed in many countries, with a focus on the principles of competency-based (CBME). A main novel aspect this context implementation entrustable professional activities (EPAs). The introduction EPAs aims to better align training curricula clinical practice, provide individualized supervision, and enhance quality feedback.
Rossi, A.; Burkhart, C. S.; Dell-Kuster, Monsch, A. U.; Strebel, S. P.; Steiner, L. Author Information
s and Programme: EUROANAESTHESIA 2011: The European Anaesthesiology Congress: Perioperative Care of the Elderly