Since outbreak in December 2019, the highly infectious and pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over a million deaths globally. With increasing burden, novel posed dire threat to public health, social interaction, global economy. Mutations SARS-CoV-2 genome are moderately evolving which might have contributed its variability, transmission, replication efficiency, virulence different regions of world.

Abstract Background β-catenin is an important unit of the Wnt/β-catenin signaling pathway, a conserved process involving several physiological activities, encompassing differentiation and cell proliferation, etc. The dysfunction or mutation in causing initiation advancement various neoplasm types, including colorectal cancer, breast etc., has been reported. Therefore, therapeutic target. Hence, designing new inhibitors targeted against will prevent cancerous cells’ involvement eliminate...

Abstract Background The novel coronavirus disease (COVID-19) has claimed lots of lives, posing a dire threat to global health. It was predicted that the outbreak in African population would be very lethal and result economic devastation owing prevalence immune-compromised population, poverty, low lifespan, fragile health care systems, poor economy, lifestyle factors. Accumulation mutations gives virus selective advantage for host invasion adaptation, higher transmissibility more virulent...

Abstract Background Factors contributing to the pathogenesis and progression of cervical cancer include poor attitude screening health intervention, late presentation, among others. Mutations in p53 gene have been attributed several cases. The present study was designed find relationships between mutation patterns carcinoma staging. Such knowledge could contribute early diagnosis cancer. Results From sequence analysis fragment isolated by polymerase chain reactions (PCR), nineteen (19)...

The burden of breast and cervical cancer is increasing exponentially, especially among women in low- mid-income countries. Early detection, hinged on screening uptake a key to higher survival rate managing outcome. present study assessed Nigerians Egyptians’ knowledge self-examination (BSE) screening. A cross-sectional questionnaire was utilized obtain 1,006 respondents via convenient sampling method. mean age 30.43 ± 6.69. About one-third participants had good (> 66%) (42%), (44%) BSE...

Use of Emergency Contraceptive Pills (ECP) is desirable in Nigeria where there high rate unwanted pregnancy. Pharmacists are expected to play important role promoting use ECP but few studies have assessed their knowledge, attitude and dispensing practice this product Nigeria. A total 211 randomly selected pharmacists practicing Ibadan Lagos metropolis completed a questionnaire that knowledge about ECP, towards contraceptive actual practices. The results showed the mean age respondents was...

Ready-to-eat meat products offer numerous benefits, but improper handling can pose severe threats to human health. Due its short life span, there is a need for adequate and preservation prevent microbial contamination. Suya, popular ready-to-eat product consumed in Nigeria, be major source of food poisoning if not processed handled properly because it predispose consumers pathogenic microorganisms, heavy metals which result from contaminated water utensils used during processing, polycyclic...

Background: The burden of breast and cervical cancer is increasing exponentially, especially among women in low- mid-income countries due to late diagnosis, unhealthy lifestyle choices adoption western lifestyles. Early detection, hinged on screening uptake a key higher survival rate managing outcome. Despite some improvement noticed developed countries, the control these preventable diseases African including Nigeria Egypt seems insurmountable. Therefore, this study focused assessing...

Tamoxifen, a non-steroidal selective estrogen receptor modulator is widely used drug for the prevention and breast cancer treatment. It binds to hormone-receptors prevent binding of cells in hormones they need growth. undergoes metabolic activation which converts it an active metabolite (endoxifen afimoxifene) by action cytochromeP450 isoforms CYP2C9, CYP2D6, CYP3A4. Notable among its side effects include hot flashes, weight loss, endometrial uterine cancer, irregular periods, stroke,...

Abstract Introduction: Cancer is a major global public health concern that claims around 2000 lives per day in Africa alone. Mortality rates are expected to rise the absence of appropriate interventions. Equity and prioritizing main obstacles cancer care Africa, as policymakers other stakeholders healthcare system do not give enough attention. All aspects continuum especially these three levels care—prevention, diagnosis, treatment/management—are negatively impacted by this neglect....

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly infectious and pathogenic virus has claimed lot of lives globally since its outbreak in December 2019 posing dire threat on public health, global economy, social human interaction. At moderate rate, mutations the SARS-CoV-2 genome are evolving which might have contributed to viral variability, transmission, replication efficiency virulence different regions world. The present study elucidated mutational landscape...

This protocol outlines the methodology for acquisition and analysis of SARS-CoV-2 genomic sequences.

Background: Within few months of its outbreak, coronavirus disease 2019 (COVID-19) has ravaged over 200 countries, resulting in a million deaths. As the curve flattens most instituted guidelines were receded to mitigate effect on citizens and national economy. Aims: To assess knowledge level adherence Nigerians Egyptians COVID-19 preventive measures. Settings Design: A validated web-based cross-sectional questionnaire was utilized obtain 915 respondents via convenient sampling technique....

Introduction: The tumour suppressor protein p53 commonly referred to as guardian of the genome plays important role in preserving through regulation programmed cell death, DNA repair, energy metabolism, cycle entry or exit and senescence. Mutations can either result a loss function gain oncogenic properties. Hence, mutations are most frequent genetic mutational alteration human cancers, associated with worse prognosis more aggressive disease outcome. Methods: To assess hotspots conserved...

Mitochondrial dysfunctions remained a pivotal mechanism in manifold neurodegenerative diseases. homeostasis within the cell is an essential aspect of biology. Mitochondria which also known as power-generating set cell, have dominant role several processes associated with genomic integrity and cellular equilibrium maintenance. They are involved maintaining optimal cells functioning guidance from possible DNA damage could lead to mutations onset Conversely, system perturbations be due...