A5080591590- Cardiovascular Disease and Adiposity
- Neonatal Health and Biochemistry
- Cardiovascular Function and Risk Factors
- Heme Oxygenase-1 and Carbon Monoxide
- Calcium signaling and nucleotide metabolism
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Cardiac Health and Mental Health
- Organ Transplantation Techniques and Outcomes
- Methemoglobinemia and Tumor Lysis Syndrome
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- Sex and Gender in Healthcare
- Redox biology and oxidative stress
- Stress and Burnout Research
- Animal Behavior and Welfare Studies
- Cardiac Structural Anomalies and Repair
- Chemotherapy-induced cardiotoxicity and mitigation
- Cellular transport and secretion
- Acute Myocardial Infarction Research
- Pediatric Hepatobiliary Diseases and Treatments
- Sulfur Compounds in Biology
- Drug-Induced Hepatotoxicity and Protection
- Congenital heart defects research
Universidad del Desarrollo
2013-2021
Clínica Alemana
2013-2019
Hospital del Trabajador
2019
Fundación Chile
2018
Universidad Nacional de Cuyo
2007-2008
Consejo Nacional de Investigaciones Científicas y Técnicas
2008
Instituto de Histología y Embriología de Mendoza
2008
University of Trieste
2004-2007
AREA Science Park
2004-2006
National University of Rosario
2002
Oxidative stress is a major pathogenetic event occurring in several liver disorders ranging from metabolic to proliferative ones, and cause of damage due Ischemia/Reperfusion (I/R) during transplantation. The main sources ROS are represented by mitochondria cytocrome P450 enzymes the hepatocyte, Kupffer cells neutrophils. Cells provided with efficient molecular strategies strictly control intracellular level maintain balance between oxidant antioxidant molecules. A cellular oxidative...
Background/Aim Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syndrome is a cluster of clinical features secondary to obesity, considered as pre-diabetic condition recognized an independent risk factor for cardiovascular diseases. To better understand the relationship between metabolic disease well development novel therapeutic strategies, animal models that reproduce etiology, course outcomes these pathologies are required. The aim this work was...
Diabetic cardiomyopathy is characterized by metabolic changes in the myocardium that promote a slow and silent dysfunction of muscle fibers, leading to remodelling heart failure, independently presence coronary artery diseases or hypertension. At present, no imaging methods allow an early diagnosis this disease. Circulating miRNAs plasma have been proposed as biomarkers prognosis several cardiac diseases. This study aimed determine whether circulating could be potential diabetic...
Oxidative stress is a major pathogenetic event occurring in several liver disorders and cause of damage due to Ischemia/Reperfusion (I/R) during transplantation. While markers chronic oxidative are well known, early protein targets injury not defined. In order identify these proteins, we used differential proteomics approach HepG2 human cells treated for 10 min with 500 microM H(2)O(2). This dose was sufficient induce slight decrease total GSH thiol content without affecting cell viability....
Endocytosis is a multistep process engaged in extracellular molecules internalization. Several proteins including the Rab GTPases family coordinate endocytic pathway. The small GTPase Rab7 present late endosome (LE) compartments being marker of maturation. interacting lysosomal protein (RILP) downstream effector that recruits functional dynein/dynactin motor complex to compartments. In study, we have found Rab24 as component endosome-lysosome degradative an atypical family, which has been...
We have shown that multidrug resistance associated protein 1 (MRP1) mediates ATP‐dependent extrusion of bilirubin, possibly limiting its potentially toxic accumulation in cells. To determine directly if Mrp1 protects cells against unconjugated bilirubin (UCB) toxicity, mouse embryo fibroblasts (MEF) were isolated from knockout (−/−) mice and their wild type (WT) (+/+) littermates. Compared to WT cells, cultured MEF exposed 40–140 nM unbound [H 3 ]‐bilirubin accumulated twice as much ( P <...
Obesity is a major global health issue.Obese patients develop metabolic syndrome, which cluster of clinical features characterized by insulin resistance and dyslipidemia.Its cardiac manifestation, diabetic cardiomyopathy, leads to heart failure.Bone marrow-derived multipotent mesenchymal stromal cells, also referred as stem cells (MSC) are envisioned therapeutic tool not only for cardiovascular diseases but other degenerative conditions.Our aim was evaluate whether the intravenous...
Dobutamine is a β-adrenergic agonist with an affinity higher for receptor expressed in the heart (β1) than receptors arteries (β2). When systemically administered, it increases cardiac demand. Thus, dobutamine unmasks abnormal rhythm or ischemic areas potentially at risk of infarction. Monitoring function during stress test can be performed by either ecocardiography catheterization. The latter invasive but more accurate and informative technique that former. Cardiac induced monitored...
Research studies involving animal experimentation are regulated by the Institutional Animal Care and Use Committee (IACUC). To this end, IACUC must integrate information provided investigators of each preclinical study veterinarians from facility in order to monitor approve process. Using a paper-based system collect health welfare data is common, albeit time-consuming practice, prone transcription reading errors, not mention inconvenient for wishing make timely collaborative decisions when...
We examined how different media composition of rewarming solutions affected ammonium detoxification function, urea synthesis and the viability hepatocytes after 72 hs cold storage in UW solution. Freshly isolated rat were incubated at 37 ºC a cell culture medium (MEM-E) with 3 mM glycine, 5 fructose 2.5 adenosine (group 1) Krebs-Heinseleit buffer fructose, 2 ornithine, 10 lactate adenosine, that was used two concentrations: 2) 3). found freshly cells produced group 1 but able to diminish...
There is a misconception that the main cause of death among women breast cancer, even physicians, who may neglect cardiovascular preventive measures in this gender Aim: To assess knowledge physicians about women.A survey was answered by 231 attending Cardiology and Gynecology Meeting.Sixty eight percent respondents indicated diseases are women. A higher proportion specialists than trainees, correctly question (72 56% respectively). No differences answers were recorded.The risk should be...
Background: Most women perceive oncological disease as their principal cause of death. However, it has been shown that cardiovascular (CVD) is currently the leading mortality in developed countries.
Introducción: La rehabilitación cardÃaca después de padecer un evento cardiovascular (CV) grave es proceso en el cual paciente establece una relación cercana con equipo médico, brindando la oportunidad conocer factores psicosociales que influyeron desenlace cardÃaco y los eventuales aprendizajes experiencia. El objetivo este estudio fue percepción sobre su propia salud mujeres participaron programa cardÃaca.