A5067200589- Air Quality and Health Impacts
- Heart Rate Variability and Autonomic Control
- Neonatal Respiratory Health Research
- Drug-Induced Hepatotoxicity and Protection
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antioxidant Activity and Oxidative Stress
- Neuroscience of respiration and sleep
- Heart rate and cardiovascular health
- Respiratory Support and Mechanisms
- Vitamin C and Antioxidants Research
- Genomics, phytochemicals, and oxidative stress
- Blood Pressure and Hypertension Studies
- Hydrogen's biological and therapeutic effects
- Liver Disease Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Alcohol Consumption and Health Effects
- Seaweed-derived Bioactive Compounds
- Free Radicals and Antioxidants
- Smoking Behavior and Cessation
- Anesthesia and Neurotoxicity Research
- Liver Disease and Transplantation
- Cancer, Stress, Anesthesia, and Immune Response
- Intensive Care Unit Cognitive Disorders
- Phytochemicals and Antioxidant Activities
Universidade Federal de Ouro Preto
2020-2024
Chronic obstructive pulmonary disease (COPD) is the major cause of morbidity and mortality worldwide, cigarette smoke a key factor in development COPD. Thus, effective therapies to prevent advancement COPD has become increasingly essential. We hypothesized that quercetin protects lungs mice exposed long-term smoke. Thirty-five C57BL/6 were (12 cigarettes per day) for 60 days pretreated with 10 mg/kg/day via orogastric gavage. After experimental protocol, animals euthanized samples collected...
Cigarette smoke is highly toxic, and it can promote increased production of reactive species inflammatory response leads to liver diseases. Quercetin a flavonoid that displays antioxidant anti-inflammatory activities in This study aimed at evaluating the protective effects quercetin on livers from mice exposed long-term cigarette exposure. Male C57BL/6 were divided into five groups: control (CG), vehicle (VG), (QG), (CSG), quercetin, (QCSG). CSG QCSG for sixty consecutive days; end...
Cigarette smoke (CS) is the major cause of preventable death worldwide, and it can also damage to extrapulmonary organs, such as liver, mainly due generation reactive oxygen species (ROS). The liver an essential organ for human survival since responsible body metabolism among other things place where many endogenous exogenous substances undergo biological transformation. Lycopene a nonprovitamin A carotenoid found in red fruits vegetables, its role potent antioxidant well known. In this...
Mechanical ventilation (MV) is a lifesaving therapy for patients with acute or chronic respiratory failure. Despite, it can also cause lung injury by inducing worsening inflammatory responses and oxidative stress. Several clinical approaches have protective effects on the lungs, including prone position exogenous surfactant; however, few studies evaluated association between two strategies, especially in individuals without previous injury. We tested hypothesis that of homogenization...
Paracetamol (APAP) overdose is the leading cause of drug-induced liver injury, to acute failure. However, role concurrent or chronic ethanol ingestion in this context requires further clarification. In study, we investigated effects and on APAP-induced hepatotoxicity. Male C57BL/6 mice were randomly allocated into four groups: control (C; water 2×/day for 7 days); APAP (single dose APAP, 500 mg/kg); (AE; a single dose—10 mL/kg, one hour later an APAP—500 (CE; ethanol—10 days; last day,...
This study aimed to evaluate the protective role of N-acetylcysteine (NAC) in cells and mice exposed formaldehyde. For vitro study, J774A.1 macrophages were incubated for 8, 16 24 h with formaldehyde or NAC assess cell viability reactive oxygen species (ROS). In vivo C57BL/6 (n = 48) divided into 6 groups: control (CG), vehicle (VG) that received saline by orogastric gavage, a group 1% (FG) groups at doses 100, 150 200 mg/Kg (FN100, FN150 FN200) period 5 days. vitro, promoted decrease...
Hypertension is linked to hyperpolarization-activated cyclic nucleotide-gated (HCN) function, expressed in excitable and non-excitable cells. Considering that the reduction heart rate (HR) improves coronary perfusion cardiac performance, Ivabradine (IVA) emerged as an important drug. AIM: Evaluate if IVA chronic treatment effect can mitigate hypertension also reverse renal damage SHR. MAIN METHODS: Rats were divided into 4 groups treated for 14 days with PBS (1ml/kg; i.p) or (1mg/kg; i.p):...