A5028452715- Research on Leishmaniasis Studies
- Angiogenesis and VEGF in Cancer
- Trypanosoma species research and implications
- Air Quality and Health Impacts
- Medicinal Plants and Neuroprotection
- Cell Adhesion Molecules Research
- Renin-Angiotensin System Studies
- Protease and Inhibitor Mechanisms
- Mesenchymal stem cell research
- Synthesis and Characterization of Heterocyclic Compounds
- Genomics, phytochemicals, and oxidative stress
- Cannabis and Cannabinoid Research
- Antioxidant Activity and Oxidative Stress
- Periodontal Regeneration and Treatments
- Click Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Hydrogen's biological and therapeutic effects
- Electrostatics and Colloid Interactions
- Field-Flow Fractionation Techniques
- Mine drainage and remediation techniques
- Cytomegalovirus and herpesvirus research
- S100 Proteins and Annexins
- Blood Coagulation and Thrombosis Mechanisms
- Biochemical and Molecular Research
- Histiocytic Disorders and Treatments
Universidade Federal de Ouro Preto
2014-2024
Universidade Federal de Minas Gerais
2001-2024
Universidade Federal do Rio Grande
2023
Centro de Excelência em Bioinformática
2016
Universidade de São Paulo
2010
The techniques used for diagnosis of canine visceral leishmaniasis (CVL) in Brazil ELISA and IFAT have been extensively questioned because the accuracy these tests. A recent change protocol excluded included Dual-Path Platform (DPP). We evaluated prevalence incidence rates Leishmania spp. before after protocol. In addition, based on our results, we propose a new alternative that is less expensive screening confirmation CVL. Plasma samples were obtained from serobank dogs cross-sectional...
We evaluated the development of arterial hypertension, cardiac function, and collagen deposition, as well level components renin-angiotensin system in heart transgenic rats that overexpress an angiotensin (Ang)-(1-7)–producing fusion protein, TGR(A1-7)3292 (TG), which induces a lifetime increase circulating levels this peptide. After 30 days induction deoxycorticosterone acetate (DOCA)-salt hypertension model, DOCA-TG were hypertensive but presented lower systolic pressure comparison with...
In this study we investigated the effects of genetic deletion Angiotensin-(1-7) receptor Mas or Angiotensin II AT2 on expression specific extracellular matrix (ECM) proteins in atria, right ventricles and atrioventricular (AV) valves neonatal adult mice. Quantification collagen types I, III VI fibronectin was performed using immunofluorescence-labeling confocal microscopy. Picrosirius red staining used for histological assessment overall distribution pattern. ECM proteins, metalloproteinases...
A crucial component of the integration between foreign implants and host is angiogenesis. However, to date, none available techniques and/or endothelial markers employed assess angiogenesis in implant/host interface seems be able highlight vascular structures convincingly. In present study we investigated compared expression two cell markers: platelet adhesion molecule (PECAM-1) (CD31) endoglin (CD105) using immunohistochemistry (IHC) immunofluorescence (IF) identify quantify newly formed...
Juvenile xanthogranuloma (JXG) is a dermatological condition of unknown etiology that rarely affects the oral mucosa. There are conflicting reports suggesting it may represent reactive virally-induced lesion associated with cytomegalovirus (CMV) infection. The present paper an additional case JXG and discusses its possible association CMV biotin-streptavidin system was used to detect early late antigens. Positive immunolabelling for both antigens demonstrated in some histiocytes lesion....
In live organisms, there is a balance between the production of reactive oxygen species (ROS) and their neutralization. The increased level these leads to condition called redox imbalance. aim this study was evaluate protective action isobenzofuranones in primary cultures hippocampal neurons subjected To accomplish this, MTT LIVE/DEAD assays were initially performed. pretreated with 1 2, higher number cells when compared that untreated ones. Regarding imbalance, significant increase...
Leishmaniases are widespread neglected diseases with an incidence of 1.6 million new cases and 40 thousand deaths per year. Leishmania parasites may show distinct, species-specific patterns virulence that lead to different clinical manifestations. It is well known successive in vitro passages (SIVP) the attenuation virulence, but neither metabolism nor pathways involved these processes understood. Herein, promastigotes a virulent L. amazonensis strain recently isolated from mice was compared...
Integrins are heterodimeric receptors composed of α and β transmembrane subunits that mediate attachment cells to the extracellular matrix counter-ligands such as ICAM-1 on adjacent cells. β2 integrin (CD18) associates with four different (CD11) form an subfamily, which has been reported be expressed exclusively leukocytes. However, recent studies indicate is also by other types Since gene for located in region human chromosome 21 associated congenital heart defects, we postulated it may...
Mining waste is rich in trace elements, which present a high toxic potential and may represent risk for aquatic ecosystems. The Fundão dam failure, considered the largest environmental disaster world, affected 663.2 km of watercourses, including Carmo Gualaxo do Norte Rivers. ore tail also riverside communities, destroying villages, killing people affecting subsistence farming. To evaluate influence mine tailing wave on water quality Rivers samples were collected at nine points located Barra...
Leishmaniases, a group of diseases caused by the species protozoan parasite Leishmania, remains significant public health concern worldwide. Host immune responses play crucial role in outcome Leishmania infections, and several mediators that regulate inflammatory are potential targets for therapeutic approaches. Annexin A1 (AnxA1), an endogenous protein endowed with anti-inflammatory pro-resolving properties, has emerged as player. We have shown during L. braziliensis infection, deficiency...