A5011043419- Psychedelics and Drug Studies
- Receptor Mechanisms and Signaling
- Tuberous Sclerosis Complex Research
- Neonatal Health and Biochemistry
- Polyamine Metabolism and Applications
- Cholinesterase and Neurodegenerative Diseases
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Drug Transport and Resistance Mechanisms
- Barrier Structure and Function Studies
- Alkaloids: synthesis and pharmacology
- Neuroscience and Neuropharmacology Research
Medizinische Hochschule Hannover
2023-2024
University of Veterinary Medicine Hannover, Foundation
2020-2021
Abstract INTRODUCTION Hyperphosphorylation and aggregation of the microtubule‐associated protein tau cause development tauopathies, such as Alzheimer's disease frontotemporal dementia (FTD). We recently uncovered a causal link between constitutive serotonin receptor 7 (5‐HT7R) activity pathological aggregation. Here, we evaluated 5‐HT7R inverse agonists novel drugs in treatment tauopathies. METHODS Based on structural homology, screened multiple approved for their agonism toward 5‐HT7R....
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Abstract Background In vitro models based on brain capillary endothelial cells (BCECs) are among the most versatile tools in blood–brain barrier research for testing drug penetration into and how this is affected by efflux transporters such as P-glycoprotein (Pgp). However, compared to freshly isolated capillaries or primary BCECs, expression of Pgp immortalized BCEC lines markedly lower, which prompted us previously transduce widely used human line hCMEC/D3 with a doxycycline-inducible MDR1...