A5053287204- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Nanofabrication and Lithography Techniques
- Zebrafish Biomedical Research Applications
- Ocular Oncology and Treatments
- Hippo pathway signaling and YAP/TAZ
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
Institute for Bioengineering of Catalonia
2021
Universitat de Barcelona
2021
Inserm
2018
Institut Curie
2018
Université Paris Sciences et Lettres
2018
Centre National de la Recherche Scientifique
2018
Sorbonne Université
2018
A major challenge in cancer research is the complexity of tumor microenvironment, which includes host immunological setting. Inspired by emerging technology organ-on-chip, we achieved 3D co-cultures microfluidic devices (integrating four cell populations: cancer, immune, endothelial, and fibroblasts) to reconstitute ex vivo a human ecosystem (HER2+ breast cancer). We visualized quantified complex dynamics this tumor-on-chip, absence or presence drug trastuzumab (Herceptin), targeted antibody...
Cutaneous melanoma is a highly aggressive cancer with propensity for distant metastasis to various organs. In contrast, arising in pigmented uveal layers of the eye metastasizes mostly liver. The mechanisms these metastases, which are ultimately resistant therapy, still unclear. Metastasis via intravascular dissemination tumour cells widely accepted as central paradigm. However, we have previously described an alternative mode dissemination, extravascular migratory metastasis, based on...
Uniform RAS activation in an epithelium induces a 2D-to-3D transformation through induction of mechanical instability.
A major challenge in cancer research is the complexity of tumor microenvironment and necessity to take into account host immunological setting. An innovative way address these problems exploit emerging technology organ-on-chip achieve co-cultures microfluidic devises that recapitulate ex vivo ecosystem.
Abstract The RAS proto-oncogene is a critical regulator of cell state, morphology and mechanics, plays key role in cancer progression. Here, by using human epithelial model vitro, we ask how morpho-mechanical changes driven oncogenic activation at the level individual cells are collectively integrated to drive tissue behaviour. We found that uniform expression HRAS.V12 confined monolayers causes reproducible structure organization tissue, which acquires transitory bilayered morphology....