A5013026922- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Hemispheric Asymmetry in Neuroscience
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Vestibular and auditory disorders
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and genetic disorders
- Advanced X-ray and CT Imaging
- Neurological Disease Mechanisms and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Radiotherapy Techniques
- Computational Drug Discovery Methods
- Peripheral Nerve Disorders
- Nanoparticles: synthesis and applications
- Lung Cancer Diagnosis and Treatment
University of Florence
2013-2020
University of Rome Tor Vergata
2015-2018
University of Essex
2015-2016
Mild cognitive impairment (MCI) is a common condition in patients with diffuse hyperintensities of cerebral white matter (WM) T2-weighted magnetic resonance images and small vessel disease (SVD). In MCI due to SVD, the most prominent feature lies degradation executive functions, i.e., processes that supervise organization execution complex behavior. The trail making test widely employed sensitive processing speed functioning. SVD has been hypothesized be effect WM damage, diffusion tensor...
Fractal dimension (FD) is an index of structural complexity cortical gray matter (GM) and white (WM). Application FD to pontocerebellar degeneration has revealed cerebellar changes. However, so far, possible concurrent cerebral changes progression in brain have not been investigated.We computed cortex WM derived from longitudinal MRI patients with spinocerebellar ataxia type 2 (SCA2), which inherited cause degeneration. Nine SCA2 16 age-matched healthy controls were examined twice (3.6 ± .7...
Diffusion tensor imaging (DTI) is sensitive to brain microstructural changes. The aims of this DTI study were map voxelwise the spatial distribution changes in patients with cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy (CADASIL) investigate any correlation between DTI-derived indices extension T2 hyperintensity.Eighteen CADASIL 18 age-, sex-, education-level-matched healthy controls underwent magnetic resonance at 3 T. Differences (mean diffusivity...
Purpose To assess the potential of histogram metrics diffusion-tensor imaging (DTI)-derived indices in revealing neurodegeneration and its progression spinocerebellar ataxia type 2 (SCA2). Materials methods Nine SCA2 patients 16 age-matched healthy controls, were examined twice (SCA2 3.6±0.7 years controls 3.3±1.0 apart) on same 1.5T scanner by acquiring T1-weighted diffusion-weighted (b-value = 1000 s/mm2) images. Cerebrum brainstem-cerebellum regions segmented using FreeSurfer suite....
<h3>BACKGROUND AND PURPOSE:</h3> Manually drawn VOI-based analysis shows a decrease in magnetization transfer ratio the hippocampus of patients with Alzheimer disease. We investigated whole-brain voxelwise regional changes mild disease and amnestic cognitive impairment. <h3>MATERIALS METHODS:</h3> Twenty disease, 27 impairment, 30 healthy elderly control subjects were examined high-resolution T1WI 3-mm-thick images. Whole-brain maps was performed by use Statistical Parametric Mapping 8...
Vascular mild cognitive impairment (VMCI) is a potentially transitional state between normal aging and vascular dementia. The presence of macroscopic white matter lesions (WML) moderate or severe extension on brain MRI the hallmark VMCI. To assess clinical relevance frequency WML in patients with VMCI independently total lesion volume (LV). In this multicenter study, we included 110 (age: 74.3 ± 6.6 years; sex: 60 women). Cognitive assessment was performed VMCI-Tuscany Neuropsychological...
Vascular mild cognitive impairment (VMCI) is a disorder in which multimodal MRI can add significant value by combining diffusion tensor imaging (DTI) with brain morphometry. In this study we implemented and compared machine learning techniques for classification between 58 VMCI patients 29 healthy subjects as well discrimination (within the group) different performances. For each subject, cortical feature vector was constructed based on parcellation subcortical volumetric segmentation DTI...
Nanoparticle (NP) toxicity is determined by a vast number of topological, sterical, physico-chemical as well biological properties, rendering priori evaluation the effect NP on tissue arduous it necessary and urgent. We aimed at mining HORIZON 2020 MODENA COST cytotoxicity database through nonlinear predictive regressor learning systems in order to assess power available descriptors assay characteristics predicting toxicity. Specifically, we assessed results assays performed 57 trained two...
In CT imaging, pulmonary emphysema appears as lung regions with Low-Attenuation Areas (LAA). this study we propose a finite element (FE) model of parenchyma, based on 2-D grid beam elements, which simulates related to smoking in imaging. Simulated LAA images were generated through space sampling the output. We employed two measurements extent: Relative Area (RA) and exponent D cumulative distribution function clusters size. The has been used compare RA computed simulated those models...
Left-handers show lower asymmetry in manual ability when compared to right-handers. Unlike right-handers, left-handers do not larger deactivation of the ipsilateral primary sensorimotor (SM1) cortex on functional magnetic resonance imaging moving their dominant than nondominant hand. However, it should be noted that morphometric MRI studies have reported no differences between right-handers and volume, thickness, or surface area SM1 cortex. In this regard, magnetization transfer (MT) is a...