A5101922324- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Genetic Neurodegenerative Diseases
- Esophageal Cancer Research and Treatment
- Neonatal and fetal brain pathology
- Multiple Myeloma Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Lung Cancer Treatments and Mutations
- Metabolism and Genetic Disorders
- Medical Imaging and Pathology Studies
- Mitochondrial Function and Pathology
- Neural and Behavioral Psychology Studies
- Cytomegalovirus and herpesvirus research
- Vestibular and auditory disorders
- Advanced Nanomaterials in Catalysis
- Aortic Disease and Treatment Approaches
- Neurofibromatosis and Schwannoma Cases
- Polyoxometalates: Synthesis and Applications
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
Azienda Ospedaliero-Universitaria Careggi
2020-2024
Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo
2009-2024
CTO Hospital
2022
University of Florence
2015-2020
Meyer Children's Hospital
2015-2018
Fondazione Stella Maris
2016
Boehringer Ingelheim (Germany)
2016
Azienda Sanitaria Unità Locale di Reggio Emilia
2015
Azienda Ospedaliero Universitaria San Giovanni Battista
1989
<h3>BACKGROUND AND PURPOSE:</h3> The ability of DTI to track the progression microstructural damage in patients with inherited ataxias has not been explored so far. We performed a longitudinal study spinocerebellar ataxia type 2. <h3>MATERIALS METHODS:</h3> Ten 2 and 16 healthy age-matched controls were examined twice (mean time between scans, 3.6 years [patients] 3.3 [controls]) on same 1.5T MR scanner. Using tract-based spatial statistics, we analyzed changes DTI-derived indices: mean...
AIM: To examine the role of [18F]FDG PET/CT for assessing response to immunotherapy in patients with some solid tumors. METHODS: Data recorded a multicenter (n = 17), retrospective database between March and November 2021 were analyzed. The sample included confirmed diagnosis tumor who underwent serial (before after one or more cycles immunotherapy), >18 years age, had follow-up at least 12 months their first scan. Patients enrolled clinical trials without cancer excluded. authors...
Diffusion tensor imaging (DTI) is sensitive to brain microstructural changes. The aims of this DTI study were map voxelwise the spatial distribution changes in patients with cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy (CADASIL) investigate any correlation between DTI-derived indices extension T2 hyperintensity.Eighteen CADASIL 18 age-, sex-, education-level-matched healthy controls underwent magnetic resonance at 3 T. Differences (mean diffusivity...
Purpose To assess the potential of histogram metrics diffusion-tensor imaging (DTI)-derived indices in revealing neurodegeneration and its progression spinocerebellar ataxia type 2 (SCA2). Materials methods Nine SCA2 patients 16 age-matched healthy controls, were examined twice (SCA2 3.6±0.7 years controls 3.3±1.0 apart) on same 1.5T scanner by acquiring T1-weighted diffusion-weighted (b-value = 1000 s/mm2) images. Cerebrum brainstem-cerebellum regions segmented using FreeSurfer suite....
Background Leptomeningeal enhancement (LME) is considered an MRI marker of leptomeningeal inflammation in inflammatory neurological disorders, including multiple sclerosis (MS). To our knowledge, no disease-modifying therapies (DMTs) have been demonstrated to affect LME number or morphology so far. Methods Monocentric study investigating the frequency and a cohort people with (pw)MS who performed 3 T brain standardized protocol (including post-contrast FLAIR sequence), exploring impact...
Abstract Purpose Cerebrovascular disease (CVD) is considered a major risk factor for fatal outcome in COVID-19. We aimed to evaluate the possible association between computed tomography (CT) signs of chronic CVD and mortality infected patients. Materials methods performed double-blind retrospective evaluation cerebral CT scans 83 COVID-19 patients looking CVD. developed rapid visual score, named CVD-CT, which summarized presence parietal calcifications dolichosis, with or without ectasia,...
Purpose: To investigate retrospective respiratory gating of three-dimensional ultrashort echo time (3D UTE) lung acquisition in free-breathing rats using k-space center self signal (DC-SG) and 3D image-based SG (3D-Img-SG).Methods: Seven were investigated with a quasi-random UTE protocol.Low-resolution time-resolved sliding-window images reconstructed golden-angle radial sparse parallel (GRASP) reconstruction to extract 3D-Img-SG signal, whereas DC-SG was extracted from the k-space.Both...
Right‐IFG and pre‐SMA are associated with inhibitory responses. We used functional Magnetic Resonance Imaging to explore whether the contralateral homotopic regions can functionally replace them. An adolescent, an extensive traumatic lesion of right cerebral hemisphere having occurred 5 years earlier, performed a motor response inhibition task (Go/Nogo), which was properly accomplished activations in left‐IFC, precuneus occipital cortex. Such remodelling is line theory ‘near...
The contribution of brain regions to visuospatial abilities according sex differences and gender identity is inconsistently described. One potential explaining factor may be the different tasks employed requiring a variable load working memory other cognitive resources. Here we asked 20 cis transgender participants undergo functional Magnetic Resonance Imaging during performance judgement line orientation test that was adapted explore basic processing while minimizing load. We show V1...
Qualitative assessment using the Deauville five-point Scale (DS) is gold standard for interim and end-of treatment positron-emission tomography (PET) interpretation in lymphoma. In present study we assessed reliability prognostic value of different semi- quantitative parameters comparison with DS PET (iPET) Hodgkin lymphoma (HL).A cohort 82 out 260 patients advanced stage HL enrolled International Validation Study (IVS), scored as 3 to 5 by expert panel was included report. Two nuclear...
Metachromatic leucodystrophy (MLD) is a rare inherited lysosomal disorder caused by reduced activity of the enzyme arylsulfatase A with accumulation sulfatides in nervous system. We report female child affected MLD who developed central precocious puberty (CPP). This association has not been described so far. The proposita, after normal growth and psychomotor development, at age 30 months presented rapidly progressive gait disturbance frequent falls loss acquired language skills. Magnetic...
Abstract Purpose Response assessment to definitive non-surgical treatment for head and neck squamous cell carcinoma (HNSCC) is centered on the role of 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET-CT) 12 weeks after treatment. The 5-point Hopkins score only qualitative system available standardized reporting, albeit limited by suboptimal positive predictive value (PPV). aim our study was explore feasibility assess diagnostic accuracy an experimental...
ABSTRACT BACKGROUND AND PURPOSE The cognitive decline in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is assumed to be due a cortical‐subcortical disconnection secondary damage the white matter (WM). Using resting state functional MRI (rsfMRI) analysis of regional homogeneity (ReHo), we examined group CADASIL patients healthy subjects order to: (1) explore possible differences between two groups; (2) assess, patients, whether any ReHo...