A5074170824- DNA Repair Mechanisms
- Glioma Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Pharmacological Effects of Natural Compounds
- Radiation Therapy and Dosimetry
- Social and Educational Sciences
- Folate and B Vitamins Research
- Radiopharmaceutical Chemistry and Applications
- Vestibular and auditory disorders
- Fish biology, ecology, and behavior
- Plant tissue culture and regeneration
- PARP inhibition in cancer therapy
- Plant Pathogens and Fungal Diseases
- Complementary and Alternative Medicine Studies
- Ichthyology and Marine Biology
- Boron Compounds in Chemistry
- Plant Disease Management Techniques
- Advanced Radiotherapy Techniques
- Pharmacogenetics and Drug Metabolism
- Amino Acid Enzymes and Metabolism
ETH Zurich
2017-2022
Department of Medical Sciences
2022
University of Bonn
2008
Temozolomide (TMZ) is a DNA-methylating agent used in cancer chemotherapy, notably for glioblastoma multiforme (GBM), where it applied as front-line drug. One of the DNA alkylation products TMZ minor lesion O6 -methylguanine (O6 MeG), which responsible nearly all genotoxic, cytotoxic, and cytostatic effects induced low-dose range relevant therapy. Here, we addressed question how many MeG adducts are required to elicit cytotoxic responses. Adduct quantification revealed that increases...
The O6-alkylguanosine adduct O6-carboxymethyldeoxyguanosine (O6-CMdG) has been detected at elevated levels in blood and tissue samples from colorectal cancer patients healthy volunteers after consuming red meat. diazo compound l-azaserine leads to the formation of O6-CMdG as well corresponding methyl O6-methyldeoxyguanosine (O6-MedG) cells is therefore wide use a chemical probe cellular studies concerning DNA damage mutation. However, there remain knowledge gaps basis by l-azaserine. To...
The protein O6-methylguanine-DNA methyltransferase (MGMT) is able to repair the mutagenic O6-methylguanine (O6-MeG) adduct back guanine. In this context, it may protect against colorectal cancer formation associated with N-nitroso compounds. Such compounds be endogenously formed by nitrosylation of amino acids, which can give rise O6-MeG and O6-carboxymethylguanine (O6-CMG) adducts. It well established that repaired MGMT. However, up now, whether O6-CMG enzyme remains unresolved. Therefore,...
Distinct cellular DNA damage repair pathways maintain the structural integrity of and protect it from mutagenic effects genotoxic exposures processes. The occurrence O6-carboxymethylguanine (O6-CMG) has been linked to meat consumption hypothesized contribute development colorectal cancer. However, fate O6-CMG is poorly characterized there contradictory data in literature as how may cells mutagenicity. To better address detect remove O6-CMG, we evaluated role two counteracting accumulation...