A5051121665- Advanced biosensing and bioanalysis techniques
- Viral Infections and Outbreaks Research
- Advanced Biosensing Techniques and Applications
- Preterm Birth and Chorioamnionitis
- Neonatal and Maternal Infections
- Advanced Fiber Laser Technologies
- Mechanical and Optical Resonators
- Diatoms and Algae Research
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Characterization
- Immune Response and Inflammation
- Photonic and Optical Devices
- Innovative Teaching Methods
- Neonatal Respiratory Health Research
- Infectious Diseases and Tuberculosis
- DNA and Nucleic Acid Chemistry
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Glycosylation and Glycoproteins Research
- Biosensors and Analytical Detection
- Various Chemistry Research Topics
- Evaluation of Teaching Practices
University of Michigan
2021-2023
Emmanuel College - Massachusetts
2016-2019
Active tuberculosis (TB) is caused by Mycobacterium (Mtb) bacteria and characterized multiple phases of infection, leading to difficulty in diagnosing treating infected individuals. Patients with latent infection (LTBI) can reactivate the active phase following perturbation dynamic bacterial immunological equilibrium, which potentially lead further Mtb transmission. However, current diagnostics often lack specificity for LTBI do not inform on TB reactivation risk. We hypothesized that immune...
Ebola virus (EBOV) is a highly infectious pathogen, with case mortality rate as high 89%. Rapid therapeutic treatments and supportive measures can drastically improve patient outcome; however, the symptoms of EBOV disease (EVD) lack specificity from other endemic diseases. Given significant symptom overlap, there critical need for sensitive, rapid diagnostics EVD. Facile diagnosis EVD remains challenge. Here, we describe sensitive diagnostic through microring resonator sensors in conjunction...
DNA aptamers that enhance calcium phosphate mineral formation were identified using a novel precipitation SELEX method. The evolved library was substantially enriched in G nucleotides and predicted G-quadruplex structures, suggesting their importance the mechanism of mineralization. This work could readily be extended to provide additional for materials synthesis.
TB remains a leading cause of morbidity and mortality worldwide. However, most infected immunocompetent individuals are asymptomatic only 5–10% these will eventually develop active during their lifetime (typically within 2 years after exposure). Therefore, rapid diagnosis efficient management who at the highest risk progression transmission remain major clinical public health challenges. In recent years, there has been important scientific progress in our understanding spectrum Mycobacterium...
DNA aptamers previously selected as calcium phosphate mineralization templates were modified and analyzed to better understand structure–function relationships explore the mechanism of templated mineralization. Aptamers created strengthen or remove a prevalent G-quadruplex structure for structural stability, affinity phosphate, influence on homogeneous heterogeneous mineralization, mineral crystallinity morphology. found modulate kinetics in concentration-dependent manner. Changes affected...
Graduate teaching assistants (GTAs) are crucial facilitators of undergraduate education, yet many begin their appointments with minimal knowledge practices. Chemistry Instructional Coaching offers GTAs at the University Michigan an opportunity to develop instructional practice through a collaborative, nonevaluative, and reflective coaching program. We implemented program designed in collaboration Knowles Teacher Initiative meet needs postsecondary setting. In cycle, trained GTA (the coach)...
Abstract Background Tuberculosis (TB) is an infectious disease that induces a complex response from the host immune system. Most carriers of bacteria experience asymptomatic, non-infectious phase, latent tuberculosis infection (LTBI), but have potential to reactivate active, contagious TB infection. Current diagnostics for are not sufficient LTBI and focused on using one biomarker, interferon-gamma (IFN-g). To build better disease, multi-biomarker approaches profile system, coupled with...
This protocol describes the use of silicon photonic microring resonator sensors for detection Ebola virus (EBOV) and Sudan (SUDV) soluble glycoprotein (sGP). encompasses biosensor functionalization chips, protein biomarkers in sera, preparing calibration standards analytical validation, quantification results from these experiments. is readily adaptable toward other analytes, including cytokines, chemokines, nucleic acids, viruses. For complete details on execution this protocol, please...
Abstract Objective: Determine the duration of chorioamnionitis-induced altered immune responses in preterm neonates. Study Design: A 7-plex immunoassay measured levels IL-1b, IL-6, IL-8, IL-10, TNF-a, CCL2 and CCL3 longitudinally residual serum samples from chorioamnionitis-exposed unexposed neonates less than 33 weeks’ gestation. Results: Chorioamnionitis-exposed demonstrated differences trends TNF-a over first month life. The elevated these inflammatory markers one to two weeks life with a...