A5082115207- Drug-Induced Hepatotoxicity and Protection
- Mitochondrial Function and Pathology
- Pesticide Exposure and Toxicity
- Diet and metabolism studies
- Pesticide and Herbicide Environmental Studies
- Sperm and Testicular Function
- Neuroscience and Neuropharmacology Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bee Products Chemical Analysis
- Bone and Dental Protein Studies
- Quinazolinone synthesis and applications
- Biochemical and Structural Characterization
- Selenium in Biological Systems
- Laser Applications in Dentistry and Medicine
- Antimicrobial Peptides and Activities
- Physical Education and Gymnastics
- Bioactive natural compounds
- Microencapsulation and Drying Processes
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Weed Control and Herbicide Applications
- Infectious Encephalopathies and Encephalitis
- Allelopathy and phytotoxic interactions
- Medicinal Plants and Bioactive Compounds
- Mercury impact and mitigation studies
Centro Universitário Herminio Ometto de Araras
2011-2022
Universidade de São Paulo
2000-2008
Abstract Mitochondria are important intracellular sources and targets of reactive oxygen species (ROS), while flavonoids, a large group secondary plant metabolites, antioxidants. Following our previous study on the energetics mitochondria exposed to flavonoids quercetin, taxifolin, catechin galangin, present work addressed antioxidant activity these compounds (1–50 µmol/L) Fe 2+ /citrate‐mediated membrane lipid peroxidation (LPO) in isolated rat liver mitochondria, running parallel studies...
We described the effects of nimesulide (<i>N</i>-[4-nitro-2-phenoxyphenyl]-methanesulfonamide) and its reduced metabolite in isolated rat hepatocytes. Nimesulide stimulated succinate-supported state 4 respiration mitochondria, indicating an uncoupling effect drug. Incubation hepatocytes with (0.1–1 mM) elicited a concentration- time-dependent decrease cell viability as assessed by lactate dehydrogenase leakage, mitochondrial membrane potential rhodamine 123 retention, ATP depression. also...
We evaluated the effects of phenothiazine derivative thioridazine on mechanisms mitochondria potentially implicated in apoptosis, such as those involving reactive oxygen species (ROS) and cytochrome c release, well involvement drug interaction with mitochondrial membrane these effects. Within 0 – 100 μ M range did not reduce free radical 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) nor it chelate iron. However, at 10 showed important antioxidant activity mitochondria, characterized by inhibition...
Basal generation of reactive oxygen species (ROS) is essential for male reproductive function, whereas high ROS levels may be linked to low quality sperm and infertility. The number antioxidants known inflict damage growing, it will interest study natural products, which have this activity. Since the epididymis play an important role in providing microenvironment maturation storage sperm, was undertaken evaluate morphometric-stereological functional alterations after chronic treatment with...
We investigated the effects of nimesulide, a recently developed non‐steroidal anti‐inflammatory drug, and metabolite resulting from reduction nitro group to an amine derivative, on succinate‐energized isolated rat liver mitochondria incubated in absence or presence 20 μ M Ca 2+ , 1 cyclosporin A (CsA) 5 ruthenium red. Nimesulide uncoupled through protonophoretic mechanism oxidized mitochondrial NAD(P)H, both presenting EC 50 approximately . Within same concentration range nimesulide induced...
Crotamine is a single-chain polypeptide with cell-penetrating properties, which considered promising molecule for clinical use. Nevertheless, its biosafety data are still scarce. Herein, we assessed the in vivo proinflammatory properties of crotamine, including local effect and systemic serum parameters. Sixty male Wistar rats were intradermically injected 200, 400 800 µg crotamine analyzed after 1, 3 7 days. Local was by determination MPO NAG activities, NO levels angiogenesis. Systemic...
Introduction: Rheumatoid arthritis (RA) causes inflammation, pain, edema, and articular degradation its treatment can be based on anti-inflammatory drugs, photobiomodulation (PBM) and/or platelet-rich plasma (PRP) that decrease cell flow promote local healing. In the present study, we evaluate effects of PBM PRP acute in Wistar rats through inflammatory oxidative stress parameters. Methods: Thirty female were assigned to five groups (n=6, each group): Control, Sham, PRP, Laser, PRP+Laser....
Este trabalho teve como objetivo avaliar o efeito da substituição do amido pré-gelatinizado por resistente no metabolismo de lipídeos e carboidratos em ratos machos Wistar. 20 foram divididos dois grupos, um grupo recebeu uma dieta com 9,5% (DAP) outro 18,1% (DAR) durante 22 dias. Foram analisados peso, consumo ração água, quantificadas as concentrações colesterol triglicerídeos soro músculo, glicogênio hepático muscular. Os dados teste Tukey (p>0,05) gráficos box-plot. Não houve...
Este trabalho teve como objetivo avaliar o efeito de dietas com amidos resistentes na prevenção da ocorrência e/ou gravidade colite pseudomembranosa animais tratados e sem antibiótico tetraciclina. O experimento foi realizado 20 ratos wistar fêmeas, divididos em quatro grupos que receberam diferentes dietas: amido pré-gelatinizado 9,5% resistente; resistente tetraciclina; 18,1% peso, consumo ração água foram monitorados durante 21 dias análise colesterol total, triglicerídeos glicogênio...