A5029277972- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Advanced Malware Detection Techniques
- Veterinary medicine and infectious diseases
- Network Security and Intrusion Detection
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Amoebic Infections and Treatments
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Toxoplasma gondii Research Studies
- Liver Diseases and Immunity
- Energy and Environment Impacts
- Virus-based gene therapy research
The Ohio State University
2020-2025
Lady Hardinge Medical College
2002
Coronaviruses cause respiratory and gastrointestinal diseases in diverse host species. Deltacoronaviruses (DCoVs) have been identified various songbird species leopard cats China. In 2009, porcine deltacoronavirus (PDCoV) was detected fecal samples from pigs Asia, but its etiologic role not until 2014, when it caused major diarrhea outbreaks swine the United States. Studies shown that PDCoV uses a conserved region of aminopeptidase N protein to infect cell lines derived multiple species,...
Abstract Strains of Rocahepevirus ratti, an emerging hepatitis E virus (HEV), have recently been found to be infectious humans. Rats are a primary reservoir the virus; thus, it is referred as “rat HEV”. often on swine farms in close contact with pigs. Our goal was determine whether may serve transmission host for zoonotic rat HEV by characterizing cDNA clone HEV, strain LCK-3110, vitro and vivo. RNA transcripts LCK-3110 were constructed assessed their replicative capacity cell culture...
Hepatitis E virus (HEV) can account for up to a 30% mortality rate in pregnant women, with highest incidences reported genotype 1 (gt1) HEV. Reasons contributing adverse maternal-fetal outcome during pregnancy HEV-infected women remain elusive part due the lack of robust tissue culture model some strains. Open reading frame (ORF4) was discovered overlapping ORF1 gt1 HEV whose protein expression is regulated via an IRES-like RNA element. To experimentally determine whether gt3 contains...
Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide. HEV associated pregnancy mortality has been reported as up to 30% in humans. Recent findings suggest may elicit effects directly reproductive system with protein found testis, RNA semen, and replication occurring placental cell types. Using a natural host model for infection, pigs, we demonstrate infectious within mature spermatozoa altered sperm viability from infected pigs. isolated remained suggesting...
Abstract Background Unlike the injectable vaccines, intranasal lipid nanoparticle (NP)-based adjuvanted vaccine is promising to protect against local infection and viral transmission. Infection of ferrets with SARS-CoV-2 results in typical respiratory disease pathology akin humans, suggesting that ferret model may be ideal for studies. Results We developed subunit containing both Spike receptor binding domain (S-RBD) Nucleocapsid (N) proteins (NP-COVID-Proteins) or their mRNA (NP-COVID-mRNA)...
Turkey arthritis reovirus (TARV) causes arthritic lameness in market-age turkeys. Since 2011, highly pathogenic TARV strains have caused significant economic losses the turkey industry due to increased culling, reduced market weights, and decreased carcass quality, necessitating more effective control measures. Autogenous vaccine prevention strategies been inefficacious partly a limited understanding of age-related susceptibility turkeys TARV. This study investigated host gut microbiota...
Abstract Nonalcoholic fatty liver disease (NAFLD), which shows similar symptoms as hemorrhage syndrome (FLHS) in chickens, is the most common cause of chronic and cancer humans. NAFLD patients FLHS chickens have demonstrated severe disorders when infected by emerging strains human hepatitis E virus (HEV) avian HEV, respectively. We sought to develop a chicken model altering diet 3-week-old white leghorn chickens. The high cholesterol, low choline (HCLC) included 7.6% fat with additional 2%...
Avian species often serve as transmission vectors and sources of recombination for viral infections due to their ability travel vast distances gregarious behaviors. Recently a novel deltacoronavirus (DCoV) was identified in sparrows. Sparrow (SpDCoV), coupled with close contact between sparrows swine carrying porcine (PDCoV) may facilitate DCoVs resulting CoV variants. We hypothesized that the spike (S) protein or receptor-binding domain (RBD) from sparrow coronaviruses (SpCoVs) enhance...
Hepatitis E virus (HEV) is an emerging viral disease known to cause acute hepatitis globally. Various genotypes of HEV have been identified that produce genotype specific lesions depending on the targeted population. Pregnant or immunosuppressed individuals develop significantly more severe in comparison general In last 40 years, we discovered tropism not restricted liver, and replication was demonstrated multiple organs. Out 10 body systems described humans, produces causing a broad range...
Abstract Rocahepevirus ratti, an emerging hepatitis E virus (HEV), has recently been found to be infectious humans. Rats are a primary reservoir of the virus; thus, it is referred as “rat HEV”. often on swine farms in close contact with pigs. Our goal was determine whether may serve transmission host for rat HEV by characterizing cDNA clone zoonotic HEV, strain LCK-3110, vitro and vivo. RNA transcripts LCK-3110 were constructed assessed their replicative capacity cell culture gnotobiotic...
Paslahepevirus balayani and Rocahepevirus ratti are genetically diverse species of hepatitis E virus [HEV]. Previously, only members the genus were known to infect humans but recently some have been found be infectious both immunocompromised immunocompetent humans. genotypes (gt) 1, 2, 4 for their detrimental effects during pregnancy, causing pregnancy-related disorders. Recent findings demonstrated ability gt3 replicate within placental cell lines, suggesting a direct effect on placenta...
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Abstract Hepatitis E virus (HEV) is an expanding zoonotic viral disease threat. Although HEV causes acute hepatitis, it increasingly being recognized as a systemic pathogen with detection and damage in extrahepatic tissues. The presence of RNA the semen chronically infected human patients absence viremia fecal shedding sperm head underscores need to understand interaction within male reproduction system. Male accessory glands secrete biofluids necessary for nourishment neutralize acidity...