A5062214539- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Advanced Neuroimaging Techniques and Applications
- Vagus Nerve Stimulation Research
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Pain Management and Placebo Effect
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Heart Rate Variability and Autonomic Control
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Memory and Neural Mechanisms
Stanford University
2018-2023
<h3>Importance</h3> Although chronic relapse is a characteristic of addiction to stimulants, conventional measures (eg, clinical, demographic, and self-report) do not robustly identify which individuals are most vulnerable relapse. <h3>Objectives</h3> To test whether drug cues associated with increased mesolimbic neural activity in patients undergoing treatment for stimulant use disorder this risk subsequent <h3>Design, Setting, Participants</h3> This prospective cohort study 76 participants...
Abstract Chronic pain may alter both affect- and value-related behaviors, which represents a potentially treatable aspect of chronic experience. Current understanding how influences the function brain reward systems, however, is limited. Using monetary incentive delay task functional magnetic resonance imaging (fMRI), we measured neural correlates anticipation outcomes in female participants with condition fibromyalgia (N = 17) age-matched, pain-free, controls 15). We hypothesized that...
Reduced medial forebrain bundle coherence is associated with greater trait impulsivity, as well stimulant use disorder.
Diffusion tractography allows identification and measurement of structural tracts in the human brain previously associated with motivated behavior animal models. Recent findings indicate that properties a tract connecting midbrain to nucleus accumbens (NAcc) are diagnosis stimulant use disorder (SUD), but not relapse. In this preregistered study, we used diffusion sample patients treated for SUD (
Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive alternative to (VNS) with implantable devices, has shown promise in treating disorders such as depression, migraine, and insomnia. Studies of these resting-state functional magnetic resonance imaging (MRI) (rsfMRI) have found sustained changes connectivity (rsFC) patients treated low frequency (1-20 Hz) taVNS. A recent study reported reductions pain scores rheumatoid arthritis after 12-week treatment high-frequency (20...
Abstract Neural responses to incentives are altered in chronic pain and by opioid use. To understand how use modulates the neural response reward/value pain, we compared brain functional magnetic resonance imaging (fMRI) a monetary incentive delay (MID) task patients with fibromyalgia taking opioids (N = 17), not healthy controls 15). Both groups of had similar levels psychological measures, clinical symptoms. nucleus accumbens anticipated reward non-loss outcomes did differ from either...
Patients with stimulant use disorder experience high rates of relapse. While neurobehavioral mechanisms involved in initiating drug have been studied extensively, less research has focused on
Neuroimaging research has begun to implicate alterations of brain reward systems in chronic pain. Previously, using functional magnetic resonance imaging (fMRI) and a monetary incentive delay (MID) task, Martucci et al. (2018) showed that neural responses anticipation outcome are altered fibromyalgia. In the present study, we aimed test replicability these separate fibromyalgia cohort. addition, study was conducted at distinct U.S. location but involved similar design. For 20 patients with...
Abstract Transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise as a non-invasive alternative to (VNS) with implantable devices, which been used treat drug-resistant epilepsy and treatment-resistant depression. Prior work functional MRI investigate the brain response taVNS, more recent also demonstrated potential therapeutic effects of high-frequency sub-threshold taVNS in rheumatoid arthritis. However, no studies date have measured on cerebral blood flow (CBF). The...
Abstract Dysregulated brain reward systems have been observed in chronic pain. Using functional magnetic resonance imaging (fMRI) and a monetary incentive delay (MID) task, Martucci et al. (2018) showed that neural responses to anticipation outcome are altered patients with fibromyalgia. The current study aimed replicate these results separate cohort of fibromyalgia recruited at new location using similar design. Twenty 20 healthy controls were included the replication study. Group fMRI...
Functional responses in the Nucleus Accumbens (NAcc) to risk- and reward-related cues can predict real-life risk-taking behavior. Since NAcc activity depends on neurotransmission from connected brain regions, projections may also risk preference. To quantify preference, we employed latent variables previously derived a comprehensive, independent study examining psychometric structure of which yielded general preference factor as well several specific factors, including capturing impulsivity....
Abstract Background Transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise as a non-invasive alternative to (VNS) with implantable devices, which been used treat drug-resistant epilepsy and treatment-resistant depression. Prior work functional MRI investigate the brain response taVNS, more recent also demonstrated potential therapeutic effects of high-frequency sub-threshold taVNS in rheumatoid arthritis. However, no studies date have measured on cerebral blood flow...