A5027544487- Alzheimer's disease research and treatments
- Endodontics and Root Canal Treatments
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Advanced biosensing and bioanalysis techniques
- Dental Radiography and Imaging
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Dental materials and restorations
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Dental Research and COVID-19
- Gut microbiota and health
- Bone fractures and treatments
- Dental Trauma and Treatments
- Phosphodiesterase function and regulation
- CRISPR and Genetic Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Evolutionary Psychology and Human Behavior
- Neurogenesis and neuroplasticity mechanisms
- Hip disorders and treatments
- Diet and metabolism studies
- HIV/AIDS drug development and treatment
Chitkara University
2019-2024
Institute of Medical Sciences
2018-2024
Government of Himachal Pradesh
2012-2024
University of Massachusetts Chan Medical School
2015-2024
University of Delhi
1988-2024
National Institute of Technology Sikkim
2024
Bose Institute
2024
Dr. Reddy's Laboratories (India)
2024
National Botanical Research Institute
2021-2023
Jawaharlal Institute of Post Graduate Medical Education and Research
2017-2022
There has been an upsurge in the number of clinical trials involving chemically modified oligonucleotide-based drug candidates after FDA approval Vitravene, Macugen, and recently, Kynamro. Over years, different types backbone, nucleobase and/or sugar-modified oligonucleotides have synthesized because natural DNA/RNA based pose some limitations, such as poor binding affinity, low degree nuclease resistance, affecting their direct use antisense therapeutics. In this review article, we discuss...
The present review aims to describe various methodologies that have been used for the synthesis of 1,2- & 1,4-dihydropyridines (DHPs) and also highlight their medicinal significance.
Alzheimer's disease (AD) is a persistent neuropathological stipulation manifested in the form of neuronal/synapse demise, formation senile plaques, hyperphosphorylated tau tangles, neuroinflammation, and apoptotic cell death. The absence therapeutic breakthrough for AD has continued quest to find suitable intervention. Apart from various candidates, cyclic AMPprotein kinase A-cAMP response element-binding protein (cAMP/PKA/CREB) pathway most sought-after drug target as bulk quality...
Interleukin-mediated deep cytokine storm, an aggressive inflammatory response to SARS-CoV-2 virus infection in COVID-19 patients, is correlated directly with lung injury, multi-organ failure, and poor prognosis of severe patients. Curcumin (CUR), a phenolic antioxidant compound obtained from turmeric (Curcuma longa L.), well-known for its strong anti-inflammatory activity. However, vivo efficacy constrained due bioavailability. Herein, we report that CUR-encapsulated polysaccharide...
Objective The purpose of this study was to evaluate the role helical CT in detecting right ventricular dysfunction (RVD) after acute pulmonary embolism (PE). Methods This a retrospective consisting 25 patients with scans positive for who had either follow-up echocardiography (23 patients) or angiography (2 patients). were reviewed findings suggestive RVD. Scans considered RVD if ventricle (RV) dilated interventricular septum deviated towards left ventricle. Results then correlated results...
Background: Thyroid hormone is a key substance in normal homeostasis, having variable influence on cell metabolism different organs. Hypothyroidism common, potentially serious, often clinically overlooked, readily diagnosed by laboratory testing, and eminently treatable. Aim: This study was conducted with the aim of finding effect regular physical exercise medium-intensity thyroid function patients already undergoing treatment for hypothyroidism. Materials Methods: A total 20 ambulatory...
Nucleic acid based therapeutics have an allure for medicinal chemists due to their potential specific control of gene expression. Persistent efforts resulted in the FDA approval nucleic drugs Vitravene™, Macugen™ and recently Kynamro™, leading a sudden leap number active clinical trials involving moieties. Beginning with antigene antisense technology, gained more potent strategies, e.g. RNA interference, ribozymes, decoy oligonucleotides aptamers. which opened up new frontiers chemistry...
Fuchs' endothelial corneal dystrophy (FECD) is the most common repeat expansion disorder. FECD impacts 4% of U.S. population and leading indication for transplantation. Most cases are caused by an expanded intronic CUG tract in TCF4 gene that forms nuclear foci, sequesters splicing factors impairs splicing. We investigated sense antisense RNA landscape at find sense-expanded transcript predominant species patient corneas. In tissue, foci number were negatively correlated with age showed no...