A5067432533- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Cannabis and Cannabinoid Research
- Substance Abuse Treatment and Outcomes
- Prenatal Substance Exposure Effects
- Stress Responses and Cortisol
- Transcranial Magnetic Stimulation Studies
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Alcohol Consumption and Health Effects
- Menopause: Health Impacts and Treatments
- Homelessness and Social Issues
- Estrogen and related hormone effects
- Bipolar Disorder and Treatment
- Cardiovascular Health and Risk Factors
- Psychosomatic Disorders and Their Treatments
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Alcoholism and Thiamine Deficiency
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Heart rate and cardiovascular health
VA Palo Alto Health Care System
2016-2025
Mental Illness Research, Education and Clinical Centers
2015-2025
Stanford University
2016-2025
Medical University of South Carolina
2023
Central Institute of Mental Health
2023
Heidelberg University
2023
Indiana University – Purdue University Indianapolis
2023
Indiana University School of Medicine
2023
University of California, Los Angeles
2023
Neurosciences Institute
2019
BACKGROUND: Alcohol and other substance use disorders (AUD/SUD) are common among youth often continue into adulthood; therefore, the neurocognitive effects of great concern. Because neuromaturation continues young adulthood, with AUD/SUD may be at risk for lasting cognitive decrements. This study prospectively examines neuropsychological functioning over 10 years as a function history outcomes. METHODS: The 51 participants consisted 18 persisting AUD/SUD, 19 remitted 14 community no followed...
Abstract Introduction The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation mild cognitive impairment (MCI)/dementia Methods Baseline food frequency questionnaires from n = 7085 women (aged 65–79 years) were used calculate Inflammatory Index (DII) scores that categorized into four groups. Cognitive function was annually, MCI all‐cause cases adjudicated centrally. Mixed effect...
Abstract Background Transcranial magnetic stimulation (TMS) offers a promising treatment avenue to modulate brain function in alcohol use disorder (AUD). To the best of our knowledge, this pilot study is first randomized, double‐blind, sham‐controlled trial deliver intermittent theta burst left dorsolateral prefrontal cortex (DLPFC) among US veterans with AUD. We hypothesized that 20 sessions real TMS are tolerable and feasible. As secondary line inquiry, we that, relative sham TMS,...
Previous studies have suggested neural disruption and reorganization in adult marijuana users. However, it remains unclear whether these effects persist adolescents after 28 days of abstinence and, if they do, what Performance x Brain Response interactions occur. Adolescent users (n=17) controls aged 16-18 years were recruited from local schools. Functional magnetic resonance imaging data collected days' monitored as participants performed a spatial working memory task. Marijuana show the...
<h3>Importance</h3> Although chronic relapse is a characteristic of addiction to stimulants, conventional measures (eg, clinical, demographic, and self-report) do not robustly identify which individuals are most vulnerable relapse. <h3>Objectives</h3> To test whether drug cues associated with increased mesolimbic neural activity in patients undergoing treatment for stimulant use disorder this risk subsequent <h3>Design, Setting, Participants</h3> This prospective cohort study 76 participants...
Postmenopausal hormone therapy may have long-term effects on cognitive function depending women's age. Postintervention follow-up was conducted with annual assessments of two randomized controlled clinical trial cohorts, beginning an average 6–7 years after study medications were terminated: 1,376 women who had enrolled in the Women's Health Initiative when aged 50–54 and 2,880 65–79 years. Women been randomly assigned to 0.625mg/d conjugated equine estrogens (CEE) for those prior...
OBJECTIVE In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether effect postmenopausal hormone therapy (HT) on incidence differs depending type 2 RESEARCH DESIGN AND METHODS The Women’s Health Initiative (WHI) randomized clinical trials assigned women to HT (0.625 mg/day conjugated equine estrogens with or without [i.e., unopposed] 2.5 medroxyprogesterone acetate) matching placebo an average 4.7–5.9...
Abstract Background While men have been found to drink more alcohol and higher rates of alcohol‐related mortality, women tend experience consequences, including psychological comorbidities worse use disorder (AUD) outcomes. However, gender differences in comorbid psychopathology associations with AUD outcomes among veterans are less well understood. Methods Veterans ( N = 126; 32 women) receiving inpatient treatment for completed baseline clinical measures the Beck Depression Inventory‐II,...
Diffusion tractography allows identification and measurement of structural tracts in the human brain previously associated with motivated behavior animal models. Recent findings indicate that properties a tract connecting midbrain to nucleus accumbens (NAcc) are diagnosis stimulant use disorder (SUD), but not relapse. In this preregistered study, we used diffusion sample patients treated for SUD (
A low level of response (LR) to alcohol is an important endophenotype associated with increased risk alcoholism. However, little known about how neural functioning may differ between individuals and high LRs alcohol. This study examined whether LR group effects on activity varied as a function acute consumption.A total 30 matched high- low-LR pairs (N = 60 healthy young adults) were recruited from the University California, San Diego, administered structured diagnostic interview laboratory...
Alcohol acutely reduces agitation and is widely used in social situations, but the neural substrates of emotion processing during its intoxication are not well understood. We examine whether alcohol's stress dampening effect may be via reduced activity cortical systems that subserve awareness bodily sensations, associated with affective distress.Blood oxygen level-dependent activation was measured through 24 functional magnetic resonance imaging sessions 12 healthy volunteers an emotional...
Intact cognition is a foundational component of one's ability to be competent stand trial. Given the cost assessing and treating incompetence, it recommended that clinicians develop efficient methods identify individuals who are most likely require intensive competence-related treatment interventions. This study sought ascertain whether brief cognitive screening instrument, Repeatable Battery for Assessment Neuropsychological Status (RBANS), could predict length stay required restore trial...
Background Alcohol dependence (AD) has global effects on brain structure and function, including frontolimbic regions regulating affective processing. Preliminary evidence suggests alcohol blunts limbic response to negative stimuli increases activation positive stimuli. Subtle gender differences are also evident during Methods Fourteen abstinent AD individuals (8 F, 6 M) 14 healthy controls (9 5 M), ages 23 60, were included in this facial processing functional magnetic resonance imaging...
A comparison of longitudinal global cognitive functioning in women Veteran and non-Veteran participants the Women's Health Initiative (WHI). We studied 7,330 aged 65–79 at baseline who participated WHI Hormone Therapy Trial its ancillary Memory Study (WHIMS). Global (Modified Mini-Mental State Examination [3MSE]) Veterans ( n = 279) non-Veterans 7,051) was compared annually for 8 years using generalized linear modeling methods. Compared with non-Veterans, were older, more likely to be...
Abstract INTRODUCTION Older military veterans often present with unique and complex risk factors for Alzheimer's disease (AD) related dementias. Increasing veteran participation in research studies offers one avenue to advance the field improve health outcomes. METHODS To this end, National Institute on Aging (NIA) Department of Veterans Affairs (VA) partnered build infrastructure, collaboration, intensify targeted recruitment veterans. This initiative, INviting InTo Enrollment Disease...
Abstract Background Alcohol use disorder (AUD) is highly prevalent among veterans in the United States. Self‐regulation skills (e.g., coping and emotion regulation) are important biopsychosocial factors for preventing relapse. However, how variation self‐regulation supports abstinence based on contextual demands understudied with AUD. Methods In a prospective longitudinal design, treatment‐seeking ( n = 120; 29 females) aged 23–91 AUD completed Abstinence Self‐Efficacy Scale to assess...