Ugonna Ihenacho

ORCID: 0000-0002-9469-8184
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About
Contact & Profiles
Research Areas
  • Air Quality and Health Impacts
  • Air Quality Monitoring and Forecasting
  • Vehicle emissions and performance
  • Cancer Risks and Factors
  • Global Cancer Incidence and Screening
  • Testicular diseases and treatments
  • Maternal and Perinatal Health Interventions
  • Craniofacial Disorders and Treatments
  • Maternal Mental Health During Pregnancy and Postpartum
  • Neonatal Respiratory Health Research
  • Smoking Behavior and Cessation
  • Breast Cancer Treatment Studies
  • Cleft Lip and Palate Research
  • Health, Environment, Cognitive Aging
  • Childhood Cancer Survivors' Quality of Life
  • Palliative Care and End-of-Life Issues
  • Nutrition, Genetics, and Disease
  • COVID-19 and healthcare impacts
  • Adolescent and Pediatric Healthcare
  • Genetic factors in colorectal cancer
  • Folate and B Vitamins Research
  • Genetic Associations and Epidemiology
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Cannabis and Cannabinoid Research
  • Ectopic Pregnancy Diagnosis and Management

University of Southern California
2016-2025

Cedars-Sinai Medical Center
2021

Keck Hospital of USC
2018-2020

University of California, Los Angeles
2019

General Department of Preventive Medicine
2016

Background Several lifestyle and environmental exposures have been suspected as risk factors for oral clefts, although few convincingly demonstrated. Studies across global diverse populations could offer additional insight given varying types levels of exposures. Methods We performed an international case–control study in the Democratic Republic Congo (133 cases, 301 controls), Vietnam (75 158 Philippines (102 152 Honduras (120 143 controls). Mothers were recruited from hospitals their...

10.1002/bdra.23417 article EN cc-by-nc-nd Birth Defects Research 2015-08-25

Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) P < 5×10−8. Most been conducted in non-Hispanic whites and East Asians; however, generalizability these findings potential for ethnic-specific variation Hispanic Latino (HL) individuals largely understudied. We describe first GWAS common genetic contributing to CRC HL (1611 cases 4330 controls). also examine known implement imputation-based...

10.1093/carcin/bgw046 article EN cc-by-nc Carcinogenesis 2016-04-18

Introduction: Colorectal cancer (CRC) is the third most common and second leading cause of death in United States (US). In 2018, World Cancer Research Fund/American Institute for (WCRF/AICR) published a score that allows combined evaluation adherence to their 2018 prevention recommendations on diet, nutrition, physical activity. We investigated associations between this score, incidence invasive colorectal adenocarcinoma across different racial ethnic populations Multiethnic Cohort Study...

10.1158/1538-7445.am2025-6206 article EN Cancer Research 2025-04-21

Abstract Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality in the United States. However, few studies have investigated racial and ethnic disparities CRC-specific multiethnic populations adults with CRC while accounting for detailed individual- neighborhood-level data. Methods: We evaluated among 5, 738 (2, 911 men, 2, 827 women) invasive colorectal adenocarcinoma cases (1993-2019) from Multiethnic Cohort Study (MEC). Cases included African American (n=1,...

10.1158/1538-7445.am2025-3603 article EN Cancer Research 2025-04-21

To evaluate interest in and patterns of use non-prescription cannabis products for symptom management amongst gynecologic cancer patients living states with legal access to medical recreational marijuana.Cross-sectional study using a novel 35-question survey distributed women diagnosed within two academic centers California Colorado. The queries demographic disease traits, both objective subjective issues surrounding management. Surveys were actively receiving treatment or under...

10.1016/j.gore.2019.100497 article EN cc-by-nc-nd Gynecologic Oncology Reports 2019-09-09

Early exposure to estrogen-like compounds has been implicated in the etiology of testicular cancer, but individual level epidemiologic data addressing this hypothesis are scarce. The synthetic estrogen diethylstilbestrol (DES) was administered during pregnancy from 1948 1971, sequelae utero have more extensively characterized females than males.By systematic review, we sought identify all research relating cancer a history diethylstilbestrol. Identified studies were critically appraised...

10.1093/jncics/pkz045 article EN cc-by-nc JNCI Cancer Spectrum 2019-06-28

Women are three times more likely to be diagnosed with thyroid cancer than men, incidence rates per 100,000 in the United States of 20.2 for women and 7.4 men. Several reproductive hormonal factors have been proposed as possible contributors risk, including age at menarche, parity, menopause, oral contraceptive use, surgical menopausal hormone therapy. Our study aimed investigate potential reproductive/hormonal a multiethnic population.

10.1089/jwh.2023.0947 article EN Journal of Women s Health 2024-05-22

PURPOSE Recent studies suggested fine particulate matter (PM 2.5 ) exposure increases the risk of breast cancer, but evidence among racially and ethnically diverse populations remains sparse. MATERIALS AND METHODS Among 58,358 California female participants Multiethnic Cohort (MEC) Study followed for an average 19.3 years (1993-2018), we used Cox proportional hazards regression to examine associations time-varying PM with invasive cancer (n = 3,524 cases; 70% African American Latino...

10.1200/jco.24.00418 article EN Journal of Clinical Oncology 2024-10-08

Objective: Complementary and integrative health (CIH) use among Hispanic adults with colorectal cancer (CRC) diagnosis is not well documented. Understanding the prevalence patterns of CIH Hispanics offers insights to uncover potential needs for clinical services. Design: Participants were age 21 years or older a first-time CRC from population-based registries in California. In-person and/or telephone-based interviews administered collect data on use. Demographic abstracted medical records....

10.1089/acm.2015.0332 article EN cc-by The Journal of Alternative and Complementary Medicine 2016-05-10

Abstract Background: Ultrafine particles (UFP) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed assess long-term exposure airport-related cancer incidence a multiethnic population Los Angeles County. Methods: Within the California Multiethnic Cohort, we examined association between incidence. Multivariable Cox proportional...

10.1158/1055-9965.epi-23-0924 article EN Cancer Epidemiology Biomarkers & Prevention 2024-02-19

While several studies have investigated maternal exposures as risk factors for oral clefts, few examined paternal factors. We conducted an international multi-centered case-control study to better understand clefts (cases = 392 and controls 234). Participants were recruited from local hospitals cleft repair surgical missions in Vietnam, the Philippines, Honduras, Morocco. Questionnaires administered fathers mothers separately elicit factor family history data. Associations between of...

10.3390/ijerph14060657 article EN International Journal of Environmental Research and Public Health 2017-06-19

Abstract Purpose The aim of this paper was to determine individual and shared levels psychosocial, behavioral, symptomological health characteristics among Hispanics with recent history cancer their primary social support person (PSSP) in the years following diagnosis. Patients Methods Recruited from a population‐based cohort study were 409 Hispanic patients previous diagnosis colorectal cancer. Forty‐seven identified PSSP, who assists medical decision‐making health‐related matters, also...

10.1002/pon.3938 article EN Psycho-Oncology 2015-08-20

Metabolic syndrome (MetS) is associated with a high risk of cardiovascular disease, leading cause death among women. MetS diagnosis at least 3 the following: blood pressure, fasting glucose, triglycerides, waist circumference, and low high-density lipoprotein cholesterol. Epidemiological studies suggest that endocrine disrupting chemical (EDC) exposure positively individual components MetS, but evidence an association between EDCs remains inconsistent. In cross-sectional analysis within...

10.1210/jendso/bvad136 article EN cc-by Journal of the Endocrine Society 2023-11-02

&lt;div&gt;AbstractBackground:&lt;p&gt;Ultrafine particles (UFP) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed assess long-term exposure airport-related cancer incidence a multiethnic population Los Angeles County.&lt;/p&gt;Methods:&lt;p&gt;Within the California Multiethnic Cohort, we examined association between...

10.1158/1055-9965.c.7209258.v1 preprint EN 2024-05-01
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