A5065099973- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Vitamin D Research Studies
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Sepsis Diagnosis and Treatment
University of Craiova
2021
Clinical Emergency Hospital Bucharest
2021
We evaluated in this cohort study the predictive ability of 23 peripheral blood parameters and ratios for treatment outcomes after 2-month intensive phase patients with PTB. In 63 out 90 that turned culture negative, a significant decrease white cell count, neutrophils, monocyte, hemoglobin, platelet, plateletcrit, erythrocyte sedimentation rate, MLR, NLR, PLR SII values anti-TB therapy compared to pretreatment was observed (p <0.001). Logistic regression analysis generated model...
Pro-inflammatory mediators play an important role in the pathogenesis of pulmonary tuberculosis. Consecutively, 26 tuberculosis patients were enrolled our study based on exclusion criteria. We have used Spearman’s correlation analysis, hierarchical clustering and regression modelling to evaluate association 11 biomarkers with culture status after antituberculosis treatment. The results demonstrated that six inflammatory 11, C-reactive protein (CRP), white blood cells (WBC), neutrophils,...
Tuberculosis (TB) remains a public health burden, after many years at attempts for its eradication. Vitamin D (VD) status has been suggested to be related TB susceptibility because it the ability regulate multiple axes of innate and adaptive host immune response. VD mediates cathelicidin (LL‑37) synthesis, cationic bactericidal peptide, through expression vitamin receptor (VDR). Host defense mechanisms include autophagy apoptosis alveolar macrophages. The present study aimed assess...