A5027999510- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Particle physics theoretical and experimental studies
- Neutrino Physics Research
- Advanced MRI Techniques and Applications
- Astrophysics and Cosmic Phenomena
- Music Technology and Sound Studies
- Acoustic Wave Phenomena Research
- Music and Audio Processing
- Pediatric Pain Management Techniques
- Childhood Cancer Survivors' Quality of Life
- Atomic and Molecular Physics
- ATP Synthase and ATPases Research
- Diverse Musicological Studies
- Dark Matter and Cosmic Phenomena
- Effects of Radiation Exposure
- Abdominal Surgery and Complications
University Hospital Heidelberg
2019
Heidelberg University
2018-2019
Heidelberger Institut für Radioonkologie
2018-2019
German Cancer Research Center
2018-2019
Ludwig-Maximilians-Universität München
2018
Karlsruhe Institute of Technology
2015-2017
Fraunhofer Institute for Building Physics
2014-2016
We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved - cosmology, astrophysics, nuclear, particle physics in each case viewed both theoretical experimental/observational perspectives. After reviewing the role active neutrinos physics, we focus on context Matter puzzle. Here, first motivation for based challenges tensions purely cold scenarios. then round out discussion by critically summarizing known...
Sterile neutrinos in the mass range of a few keV are candidates for both cold and warm dark matter. An admixture heavy neutrino eigenstate to electron would result minuscule distortion---a kink---in $\ensuremath{\beta}$-decay spectrum. In this paper we show that wavelet transform is very powerful shape analysis method detect signature. For tritium source strength, similar what expected from KATRIN experiment, statistical sensitivity active-to-sterile mixing down...
Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional dose. We use 4DMRI investigate interplay effect for pencil beam scanning (PBS) proton therapy of pancreatic cancer and quantify dependency residual effects on number treatment fractions. Based repeated datasets nine patients, synthetic 4DCTs were generated by warping static 3DCTs deformation vector fields. 4D dose calculations scanned...
4D magnetic resonance imaging (4DMRI) has a high potential for pancreatic cancer treatments using proton therapy, by providing time-resolved volumetric images with soft-tissue contrast without exposing the patient to any additional dose. In this study, we aim show feasibility of treatment planning pencil beam scanning (PBS) therapy cancer, based on five repeated 4DMRI datasets and dose calculations (4DDC) one patient. To investigate dosimetric impacts organ motion, deformation vector fields...
Abdominal organ motion may lead to considerable uncertainties in pencil-beam scanning (PBS) proton therapy of pancreatic cancer. Beam gating, where irradiation only occurs certain breathing phases which the gating conditions are fulfilled, be an option reduce interplay effect between tumor and beam. This study aims to, first, determine suitable windows with respect effectiveness (low effect) efficiency (high duty cycles). Second, it investigates whether beam allows for a better mitigation...
Time-resolved magnetic resonance imaging (4DMRI) provides spatial motion information with high soft-tissue contrast. This study exploits the potential of 4DMRI by investigation inter- and intrafractional pancreas deformation different patient immobilization devices. In total, 150 scans were acquired for a cohort 5 volunteers, each was scanned in 10 sessions using three positioning modes (flat table top (FTT), vacuum bag (VB), abdominal corset (AC)), respectively, to simulate repeated 4DMR...
Abstract Background and purpose Abdominal organ motion seriously compromises the targeting accuracy for particle therapy in patients with pancreatic adenocarcinoma. This study compares three different abdominal corsets regarding their ability to reduce potential usability therapy. Materials methods A patient‐individualized polyurethane (PU), a semi‐individualized polyethylene (PE), three‐dimensional‐scan based (3D‐PE) corset were manufactured one healthy volunteer. Time‐resolved volumetric...
ADC non-linearities are a major systematic effect in the search for keV-scale sterile neutrinos with tritium $\beta$-decay experiments like KATRIN. They can significantly distort spectral shape and thereby obscure tiny kink-like signature of neutrino. In this work we demonstrate various mitigation techniques to reduce impact on spectrum level $<$ ppm. The best results achieved multi-pixel ($\geq10^4$ pixels) detector using full waveform digitization. case, active-to-sterile mixing angles...
Purpose Systems for integrated magnetic resonance guided radiation therapy (MRgRT) provide real‐time and online MRI guidance unequaled targeting performance of moving tumors organs at risk. The clinical introduction such systems requires dedicated methods commissioning routine machine quality assurance (QA). aim the study was to develop a protocol method automatic quantification target motion geometric accuracy using 4D phantom. Materials performed on clinically used 3 T MR scanner. phantom...
The sound characteristics of both labial and lingual organ pipes are affected to a great extent by the reflection properties resonators. In this paper, sloped pipe terminations examined possible applications in building practice investigated. Sloped shallots reed with different termination angles particular interest study. For examination two approaches applied. Sound pulse measurements on model geometries provide experimental data time domain, while finite element simulations yield...
between planned and delivered doses.
The focus of investigations was the influence certain shallot parameters on sound reed pipes. Since dimensioning organ pipes is mainly based experience builders at present, aim to provide scientific data for explaining various sound. Due this knowledge, it would be possible realize desired ideas by targeted adjustment these during investigated Trompete shallots differ in termination angle shallot. To analyze parameter termination, measurements were carried out a simple model, which findings...
Purpose or ObjectiveAs MRgRT becomes increasingly important in clinical applications, the development of new QA methods is needed.Especially for verification MR-based gating techniques, workflows tests with 2D and 3D dose prior implementation are desirable.In this work, we present an MR compatible motion phantom that can hold both film polymer gel (PG) inserts to perform measurements gated treatments. Material MethodsA water-filled cylindrical (d = 22 cm, l= 50 cm) holding a movable smaller...