A5053534420- Brucella: diagnosis, epidemiology, treatment
- Inflammasome and immune disorders
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Travel-related health issues
- Pediatric health and respiratory diseases
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
Universidade Federal de Minas Gerais
2018-2021
Antibiotic-induced dysbiosis is a key predisposing factor for Clostridium difficile infections (CDIs), which cause intestinal disease ranging from mild diarrhea to pseudomembranous colitis. Here, we examined the impact of microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model CDI. We found that administration acetate remarkably beneficial in ameliorating disease. Mechanistically, show enhances innate immune responses by acting both neutrophils and ILC3s...
Innate immune response against Brucella abortus involves activation of Toll-like receptors (TLRs) and NOD-like (NLRs). Among the NLRs involved in recognition B. are NLRP3 AIM2. Here, we demonstrate that triggers non-canonical inflammasome dependent on caspase-11 gasdermin-D (GSDMD). Additionally, identify Brucella-LPS is ligand for activation. Interestingly, determine able to trigger pyroptosis leading pore formation cell death, this process GSDMD but independently caspase-1 protease...
Brucella abortus is a Gram-negative bacterium responsible for worldwide zoonotic infection—Brucellosis, which has been associated with high morbidity rate in humans and severe economic losses infected livestock. The natural route of infection through oral nasal mucosa but the invasion process host gut yet to be understood. Studies have examined role NLRP6 (NOD-like receptor family pyrin domain-containing-6 protein) homeostasis defense against pathogens. Here, we investigated impact...
The ST2 receptor plays an important role in the gut such as permeability regulation, epithelium regeneration, and promoting intestinal immune modulation. Here, we studied of a murine model oral infection with Brucella abortus, its influence on homeostasis control bacterial replication. Balb/c (wild-type, WT) deficient mice (ST2−/−) were infected by gavage results obtained at 3 14 days post (dpi). Our suggest that ST2−/− are more resistant to B. abortus infection, lower colony-forming unit...