A5080182296- Trypanosoma species research and implications
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Research on Leishmaniasis Studies
- Gastrointestinal motility and disorders
- Viral gastroenteritis research and epidemiology
- Coenzyme Q10 studies and effects
- Lymphoma Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Parasites and Host Interactions
- Herpesvirus Infections and Treatments
- Lysosomal Storage Disorders Research
- Cytomegalovirus and herpesvirus research
- Glycogen Storage Diseases and Myoclonus
- Toxoplasma gondii Research Studies
- Microbial Metabolites in Food Biotechnology
- Eosinophilic Disorders and Syndromes
- Galectins and Cancer Biology
- Child Nutrition and Feeding Issues
- Systemic Lupus Erythematosus Research
- Macrophage Migration Inhibitory Factor
- Monoclonal and Polyclonal Antibodies Research
- Salmonella and Campylobacter epidemiology
- Tryptophan and brain disorders
Universidade Federal de Minas Gerais
2018-2024
University of Florence
1990
Long-term sequelae of coronavirus disease (COVID)-19 are frequent and major concern. Severe acute respiratory syndrome 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to severity in patients with COVID-19. Here, we report that microbiota post-COVID subjects had a remarkable predominance Enterobacteriaceae strains an antibiotic-resistant phenotype compared healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced feces. Fecal transplantation...
<title>Abstract</title> Background There is mounting evidence that SARS-CoV-2 targets tissues beyond the respiratory tract. Long-term sequelae after COVID-19 are frequent and of major concern. Prolonged virus detection in gut has been particularly intriguing. Of note, infection also disturbs microbiota composition, a finding linked with disease severity patients COVID-19. Here, we aimed to characterize functional role long-term consequences To this end, characterized from human subjects...
There is a growing consensus that the balance between persistence of infection and host immune response crucial for chronification Chagas heart disease. Extrapolation chagasic megacolon hampered because research in humans animal models reproduce intestinal pathology lacking. The parasite-host relationship its consequence to disease are not well known. Our model describes temporal changes mice intestine wall throughout infection, parasitism, development megacolon. It also presents primary...
Antinuclear antibodies, circulating immune complexes, rheumatoid factors and anticardiolipin antibodies were detected in the sera of 17 patients affected by limited cutaneous subset systemic sclerosis marked clinical evidence ischaemic lesions (fingertip ulcerations). This study was designed to evaluate possible role (aCL) other immunological disorders endothelial damage characteristic disease. ACL found 41% patients. With exception a significant connection with positive factor tests (RIA),...
Kefir is a beverage obtained by fermentation of milk or sugar solution lactic acid bacteria and yeasts, several health benefits have been attributed to its ingestion, part them being Lactobacillus species. The objective the present study was evaluate, in vivo, probiotic potential diolivorans 1Z, isolated from Brazilian kefir grains. Initially, conventional mice were orally treated daily not during 10 days with suspension L. then challenged Salmonella enterica serovar Typhimurium. Treatment...
Two billion people are chronically infected with Toxoplasma gondii worldwide unknown consequences. Important neurological diseases have been associated to the brain infection, making essential understand neurophysiological changes neuronal encystment. T. may subvert functions modifying neurotransmitter concentration in mice but molecular mechanisms involved still unclear. Parasites were observed inside cells cultures from 24-192 hs. The rate of infection increased time. Neurite density...
<title>Abstract</title> Long-term sequelae after Coronavirus disease (COVID)-19 are frequent and of major concern. SARS-CoV-2 infection affects the host's gut microbiota, which is linked with severity in patients COVID-19. We report here that microbiota post-COVID subjects had a remarkable predominance <italic>Enterobacteriaceae </italic>strains antibiotic-resistance phenotype compared to healthy controls. Additionally, short-chain fatty acids (SCFA) levels were reduced their feces. Fecal...
The ST2 receptor plays an important role in the gut such as permeability regulation, epithelium regeneration, and promoting intestinal immune modulation. Here, we studied of a murine model oral infection with Brucella abortus, its influence on homeostasis control bacterial replication. Balb/c (wild-type, WT) deficient mice (ST2−/−) were infected by gavage results obtained at 3 14 days post (dpi). Our suggest that ST2−/− are more resistant to B. abortus infection, lower colony-forming unit...
Digestive and cardiodigestive forms of Chagas' disease are observed in 2% to 27% the patients, depending on their geographic location, Trypanosoma cruzi strain immunopathological responses. The aim this work was evaluate role NOD2 innate immune receptor pathogenesis digestive system disease. Patients with form showed lower mRNA expression NOD2, higher RIP2 α-defensin 6, compared indeterminate form, detected by Real-time PCR peripheral blood mononuclear cells. In addition, there a negative...
Chagas disease is a chronic disorder caused by the Trypanosoma cruzi protozoan. The infection causes alterations to enteric nervous system such as megaesophagus and megacolon. There evidence of denervation myenteric ganglia. intense parasitism acute phase affects neuronal integrity but contrasts with absence parasites discreet inflammatory process phase, indicating progressive injury mechanism that needs be better understood in megacolons. potential selectivity neurons classes affected...
Disorders of gastrointestinal motility are the major physiologic problem in chagasic megacolon. The contraction mechanism is complex and controlled by different cell types such as enteric neurons, smooth muscle, telocytes, an important pacemaker intestine, interstitial cells Cajal (ICCs). role ICCs progression acute chronic Chagas disease remains unclear. In present work, we investigate aspects a long-term model that mimics pathological human Different subsets isolated from Auerbach's...
Chronic Chagas cardiomyopathy is associated with an unbalanced immune response and impaired heart function, available drugs do not prevent its development. Zileuton (Zi), a 5-lypoxigenase inhibitor, affects inflammatory/pro-resolution mediators. Herein, Zi treatment in the early phase of infection reduced parasitemia mainly direct effect on parasite, enzyme epoxide hydrolase was potential molecular target behind trypanocidal effect. In intermediate acute infection, number innate adaptive...
Acute chagasic encephalitis is a clinically severe central nervous system (CNS) manifestation. However, the knowledge of form Chagas disease incomplete. The role muscarinic acetylcholine receptor (mAChR) on mice behavior and brain lesions induced by Trypanosoma cruzi (Colombian strain) was herein investigated in treated with mAChR agonist antagonist (carbachol atropine), respectively. Immunosuppressed or non-immunosuppressed were intracerebroventricularly (icv) intraperitoneally (ip)...
Chagasic megacolon is caused by Trypanosoma cruzi, which promotes in several cases, irreversible segmental colonic dilation. This alteration the major anatomic-clinical disorder, characterized enteric nervous system and muscle wall structural damage. Herein, we investigate how T. cruzi -induced progressive changes modulate contractile pattern activity.We developed a murine model of cruzi-infection that reproduced long-term modifications enlarged colon. We evaluated total intestinal transit...
Abstract Functional foods containing probiotics are generally administered as dairy products. Non-dairy beverages another possibility, but probiotic functionality must be confirmed in such vehicles. In the present study, a craft wheat beer brewed with yeast Saccharomyces cerevisiae UFMG A-905 (905) was evaluated murine model of Salmonella Typhimurium (ST) infection. Unfiltered or filtered 905, commercial used negative control, saline were orally to mice before and during oral ST challenge....