A5037997321- Tuberculosis Research and Epidemiology
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Congenital gastrointestinal and neural anomalies
- Vibrio bacteria research studies
- Complementary and Alternative Medicine Studies
- Pneumonia and Respiratory Infections
- Salmonella and Campylobacter epidemiology
- Bartonella species infections research
- Digital Imaging for Blood Diseases
- Healthcare Policy and Management
- Patient Satisfaction in Healthcare
- Rabies epidemiology and control
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Resistance in Staphylococcus
- Pharmaceutical studies and practices
- Infectious Diseases and Tuberculosis
- COVID-19 diagnosis using AI
- Gastrointestinal disorders and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Adolescent and Pediatric Healthcare
Novel (Germany)
2023-2024
Otsuka (Germany)
2023-2024
Task Applied Science
2018
National Health Laboratory Service
2013-2016
University of Cape Town
2013-2014
Groote Schuur Hospital
2013
BackgroundAntibiotic consumption is a major driver of bacterial resistance. To address the increasing burden multi-drug resistant infections, antibiotic stewardship programmes are promoted worldwide to rationalize prescribing and conserve remaining antibiotics. Few studies have been reported from developing countries none Africa that report on an intervention based approach with outcomes include morbidity mortality. MethodsAn prescription chart weekly ward round was introduced into two...
Objective: In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack accurate, rapid diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic for detection mycobacterial lipoarabinomannan (LAM) in urine. Our objective was to determine sensitivity specificity the diagnosis. Design: Prospective accuracy study. Setting: Hospital outpatient Uganda South Africa. Participants:...
The polymyxin antibiotic colistin is an of last resort for the treatment extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. State World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence these 'superbugs' (3.2% Klebsiella pneumoniae reported from SA were carbapenemase producers), and doing so, underscored SA's reliance on as a line defence. Colistin resistance effectively renders such increasingly common...
The currently recommended rifampicin dose (10 mg/kg) for treating tuberculosis is suboptimal. PanACEA HIGHRIF1 trial evaluated the pharmacokinetics and early bactericidal activity of doses up to 40 mg/kg. Conventional statistical analyses revealed no significant exposure-response relationship. Our objectives were explore relationship high-dose by using pharmacokinetic-pharmacodynamic modeling predict 50 mg/kg rifampicin. Data included time Mycobacterium positivity liquid cultures sputum...
Workers in clinical microbiology laboratories are exposed to a variety of pathogenic microorganisms. Salmonella species is among the most commonly reported bacterial causes laboratory-acquired infections. We report on three cases enterica serotype Typhi (Salmonella Typhi) infection which occurred over period 2012 2016 South Africa. Laboratory investigation included phenotypic and genotypic characterization isolates. Phenotypic analysis standard microbiological identification techniques,...
In-patient hospitals in South Africa and Uganda.To evaluate the cost-effectiveness of a lateral-flow urine lipoarabinomannan (LAM) test when added to existing strategies for tuberculosis (TB) diagnosis human immunodeficiency virus infected adults (CD4(+) T-cell counts < 100 cells/l) with symptoms active TB.Decision-analytic cost-utility model, primary outcome being incremental ratio, expressed 2010 US dollars per disability-adjusted life year (DALY) averted from perspective public sector TB...
ABSTRACT Acinetobacter baumannii is a major nosocomial pathogen causing infections in critically ill patients. This organism has acquired the propensity to rapidly develop resistance most antibiotics. At several hospitals within Cape Town, South Africa, tobramycin and colistin are frequently only therapeutic options. Vitek2 automated susceptibility testing (AST) used clinical laboratory determine selected profiles. The suspicion of possible AST-related technical error when for A....
Bartonella spp. was first described as a possible cause of culture-negative endocarditis in 1993, and has since emerged significant this condition worldwide. We describe complicated case an immune-competent male patient, which confirmed on resected heart valves to have been caused by quintana broad-range 16S ribosomal RNA polymerase chain reaction. The objective report is highlight the clinical, diagnostic therapeutic challenges endocarditis.
intussusception in South African (SA) children is often severe. A proportion of cases require management at quaternary hospitals which are a scare resource SA. geospatial investigation severe paediatric (SPI) the KwaZulu-Natal (KZN) province SA would assist with identifying regions should be targeted for preventative interventions. This could reduce utilisation this condition hospitals. The objective study was to determine distribution SPI KZN.this retrospective analysis data patients who...
Antimicrobial susceptibility testing, based on clinical breakpoints that incorporate pharmacokinetics/pharmacodynamics (PK/PD) and outcomes, is becoming a new standard in guiding individual patient therapy as well for drug resistance surveillance. However, most antituberculosis drugs, are instead defined by the epidemiological cutoff values of MIC phenotypically wild-type strains irrespective PK/PD or dose. In this study, we determined breakpoint delamanid estimating probability target...