A5070252966- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Nitric Oxide and Endothelin Effects
- Obstructive Sleep Apnea Research
- Restless Legs Syndrome Research
- High Altitude and Hypoxia
- Sports Performance and Training
- Spectroscopy and Chemometric Analyses
- Neuroscience of respiration and sleep
- Pancreatic function and diabetes
- Advanced Sensor and Energy Harvesting Materials
- Respiratory Support and Mechanisms
- Spaceflight effects on biology
- Pharmacological Effects and Assays
- Diabetes Treatment and Management
- Exercise and Physiological Responses
- Sleep and related disorders
- Cardiovascular Health and Disease Prevention
- Sleep and Wakefulness Research
- Diabetes Management and Research
- Advanced Chemical Sensor Technologies
- Spectroscopy Techniques in Biomedical and Chemical Research
Centre Hospitalier Universitaire de Grenoble
2022
Université Grenoble Alpes
2015-2021
Inserm
2015-2021
Physiopathologie et Epidémiologie des Maladies Respiratoires
2018
The central nervous system can play a critical role in limiting exercise performance during hypoxic conditions. Hypocapnia, which is associated with hypoxia-induced hyperventilation, may affect cerebral perfusion. We hypothesized that CO2 clamping isometric knee extensions would improve oxygenation and reduce fatigue.Fifteen healthy men (mean ± SD: age, 25 8 yr; body mass, 72 11 kg; height, 179 7 cm) performed intermittent at ∼50% of maximal voluntary contraction to task failure normoxia,...
Ultramarathon running includes two main types of events: single-stage race (SSR) and multistage races (MSR). Direct comparison neuromuscular fatigue recovery after SSR versus MSR comparable distance elevation has never been performed. The aim this study was to assess ultramarathons equal performed either (i) in a single stage or (ii) four successive days.Thirty-one runners participated the study: 17 ran 169 km 14 around 40 km·d over 4 d. were on same course. Neuromuscular function tested...
Nitric oxide (NO) is implicated in vasomotor control mechanisms altering the diameter of vessels under various physiological and pathological conditions. There are 2 main NO production pathways, 1 synthase (NOS) independent (nitrate-nitrite-NO) other NOS dependent (citrulline-arginine-NO). The objective study was to evaluate effect acute nitrate citrulline supplementation on post-ischemic vascular response healthy subjects. Fourteen subjects performed 2-leg occlusion tests, 3 days apart....
Lower muscle strength and endurance have been reported in severe obstructive sleep apnea (OSA). Increased intracortical inhibition previously at rest OSA suggests central neuromuscular impairments these patients. We hypothesized that (i) patients demonstrate reduced knee extensor due to (ii) continuous positive airway pressure (CPAP) treatment improves function patients.Twelve 11 healthy controls performed intermittent extensions until task failure before after 8 wk of CPAP or control...
Increased nitric oxide (NO) bioavailability may improve exercise performance and vascular function. It remains unclear whether older adults who experience a decreased NO benefit from chronic precursor supplementation. This randomised, double-blind, trial aims to assess the effect of intake on function in (60-70 years old). Twenty-four healthy (12 females) performed assessment both local (knee extensions) whole-body (incremental cycling) tests exhaustion before after one month daily placebo...
New Findings What is the central question of this study ? effect acute NO precursor intake on vascular function, muscle and cerebral oxygenation peripheral neuromuscular fatigue during knee‐extension exercise? main finding its importance Acute ingestion increases plasma concentrations precursors (nitrate, arginine citrulline) enhances post‐ischaemic vasodilatation, but has no significant oxygenation, mechanisms and, consequently, does not improve exercise performance. Abstract Nitric oxide...
ABSTRACT Introduction Nitric oxide (NO) precursor supplementation has been shown to increase NO bioavailability and can potentially improve vascular function exercise performance. It remains unclear whether the combination of training synergic effects on This study aims assess effect chronic nitrate citrulline intake adaptations in healthy young individuals. Methods In this randomized, double-bind trial, 24 (12 females) subjects performed assessment (blood pressure, pulse wave velocity,...
Abstract To determine the effect of continuous positive airway pressure (CPAP), gold standard treatment for obstructive sleep apnea syndrome (OSAS), on gait control in severe OSAS patients. We conducted a randomized, double-blind, parallel-group, sham-controlled monocentric study Grenoble Alpes University Hospital, France. Gait parameters were recorded under single and dual-task conditions using visuo-verbal cognitive task (Stroop test), before after 8-week intervention period. Stride-time...
Introducing NEOGLY™, a novel body-worn QCL-based non-invasive continuous glucose monitoring device (NI-CGM). Developed under ISO 13485 regulation, it shows relevant glycemia predictions based on mid-infrared photoacoustic spectroscopy as well AI-based algorithms fed by digital twin that covers the entire detection chain including modeling and human skin properties.
ABSTRACT Purpose Ergogenic effect in physically active subjects has been reported after acute salbutamol (SAL) intake. β 2 -Agonists have potential stimulant effects within the central nervous system that could be involved this ergogenic effect. We hypothesized SAL intake would induce changes cerebral responses during exercise, with significant improvement oxygenation and voluntary activation (VA) contributing to an increase muscle performance. Methods Fourteen trained male (25 ± 5 yr)...
Lower muscle strength and endurance have been reported in severe obstructive sleep apnea syndrome (OSAS) patients. Increased intracortical inhibition previously at rest OSAS suggests central neuromuscular impairments these This study investigated the mechanisms of exercise-induced fatigue patients before after an 8-week continuous positive airway pressure (CPAP) treatment. Twelve (age 59±7 yrs; BMI 27±3 kg·m<sup>−2</sup>; AHI 46±13 events·h<sup>−1</sup>) 11 matched controls were included....