Healthcare workers are one of the main risk groups for COVID-19 infection and should be provided priority protection. Objective. To examine development dynamics epidemic process manifestations in healthcare as well to assess efficacy intranasal human recombinant interferon alpha-2b (Grippferon®) emergency medicationassisted nonspecific prevention novel coronavirus infection. Patients methods. The incidence Perm was examined using official statistical data dynamics. prophylactic Grippferon®...

Objective. Since the territory of Western Urals is widely known for its high morbidity and mortality rates associated with tick-borne infections, including ixodic borreliosis, study was aimed at estimation role specific prevention in prevalence ITB.
 Materials methods. A continuous retrospective clinical laboratory analysis 1214 adult patients admitted to Perm Regional Clinical Infectious Disease Hospital lyme - borreliosis 2012-2019 carried out.
 Results. The disease registered...

Objective. To analyze the effectiveness of etiotropic antiviral therapy with direct drugs against chronic viral hepatitis C in adult population Perm Krai.
 Materials and methods. In regional register Krai, 20095 patients were registered. 2019–2021, drugs, registered Russian Federation, included list vital essential medicines for medical use was prescribed to 282 C. There 137 men (48.6 %), 145 (51.4 %) – women. The age ranged from 26 82 years, duration disease 3 25 years.
 Results....

Objective. To study the dynamics of main markers protein metabolism and microelements in patients with a new coronavirus infection. Materials methods. A prospective clinical laboratory was carried out 62 infection complicated by development pneumonia moderate course on basis Perm regional hospital infectious diseases 2021–2022. On 1st 14th days hospitalization all underwent general biochemical studies. The concentrations total protein, albumin, transferrin, Fe, Zn Cu also determined....

A clinical case of HIV-associated Kaposi's sarcoma with skin and lung lesions is presented. patient referred to the Perm Regional Center for Prevention Control AIDS Infectious Diseases complaining rash on right wing nose, forehead, in axillary inguinal areas, shins. The first changes occurred December 2020 later pathological process spread other areas skin. HIV was revealed 2009 had not received specialized medical care until 2022 as he been prison. Since March 2022, has registered at...

Aim. To study the changes in nutritive status of HIV-positive patients, hospitalized with community-acquired pneumonias, caused by Streptococcus pneumoniae.
 Materials and methods. During 2014–2017, clinicolaboratory examination 676 patients was carried out on basis Perm Regional Clinical Infectious Hospital. There were formed groups “observation”, including pneumoniae lethal outcomes, “comparison”, discharged from hospital satisfactory status.
 Results. Negative dynamics status,...

Objective. The incidence rate of tick-borne encephalitis in Perm Krai annually exceeds that the Russian Federation by several times, and therefore, aim study was to reveal clinical epidemiological characteristics course infection.
 Materials methods. A continuous retrospective laboratory survey including 314 adult patients admitted Regional Clinical Infectious Diseases Hospital 2014-2019 carried out.
 Results. following features were revealed: disease is diagnosed more often...

Objectives. The purpose of this study is a comparative assessment the dynamics key markers protein and micronutrient metabolism disorders in ICU patients with acute abdominal disease survivors non-survivors. Materials methods. A continuous screening was carried out for 532 hospitalized surgical ICU. After analyzing registration cards, two comparable groups were formed. Group 1 — survived patients. 2 negative clinical outcome. Results. Serum albumin transferrin both reduced already upon...

The current study was carried out to the influence of light and heavy lanthanides on physiological process Crimean-Sagyz/ Krim-saghyz (dandelion - Taraxacum hybernum). Lanthanide belongs group or heavy; infiltration dandelion (Crimean saghyz) seeds with solutions increased germination energy by 26%. differences in (cerium) (lutetium) were manifested quantum efficiency change photosystem 2 (PS II). Treatment leaves high concentrations (100 µM) led a decrease Y (II), moreover, under...

Abstract. The article presents results of a prospective randomized study reactogenicity, safety and immunogenicity the polysaccharide pneumococcal vaccine “Pneumo 23” in group medical workers. was characterized by high profile (absence clinical symptoms allergy, changes blood urine), low reactogenicity sufficient immunogenicity.

Streptococcus pneumonia – one of the reasons for appearance complications from influenza and acute respiratory diseases, occurring with a lesion ENT organs and respiratory system. In this regard, there is substantial need for use additional methods laboratory testing for verification pathogen. Diagnostics complications from diseases caused by pneumococcal flora has been carried out immunochromatographic assay. Microbiological examination revealed etiology of only in 14,0% cases, but...

At present, the problem of vaccination HIV-infected patients from pneumococcal disease is still poorly studied. There no consensus on effectiveness immunization, appropriateness and timing revaccination. The aim study was to examine duration power post-vaccination immunity in adult patients. A prospective comparative randomized performed, 100 were vaccinated with a polysaccharide 23-valent vaccine. Comparison group consisted cases, not against infection. For detection through 2 years blood...

Currently registration of community-acquired pneumonia and purulent meningitis caused by S. rneumoniae patients in HIV-positive patientsis is not carried out, there absent the description clinical symptom complex. In this regard, purpose work was detection features course pneumococcal infection with lesion respiratory nervous systems HIV infection. A laboratory examination 110 bacterialpneumonias andpurulent meningitises performed. Community-acquiredpneumonia fulminates massive damage lung...

The objective of the study was to analyze clinical picture hydatid echinococcosis with combined damage liver and lungs as well tactics management treatment. A observation a patient is presented. Information from medical record an inpatient results examination, instrumental laboratory diagnostic methods used. case characterized by delay in surgical intervention severe course infection. need for increased attention practitioners indicated; individual work each prevent course, possible...

Aim. To study the duration and tension of postvaccinal pneumococcal immunity in HIV-positive patients, immunized with polysaccharide vaccine.
 Materials methods. One hundred HIV-infected patients (age range 20 to 50 years) stages 3 4 A disease, having number CD4+ T-lymphocytes blood not less than 440 mcl–1, were 23-valent Results. The maximum effect regarding vaccine immunization persons was established at stage disease. When immunizing decrease CD4+- 310 [300; 330] cells per mcl-1,...

Aim. To study the state of central hemodynamics, oxygen metabolism and tissue blood flow in patients with influenza who suffered from hypertensive reaction detected for first time, dynamics infectious process.
 Materials methods. At Perm Regional Clinical Infectious Hospital, 65 underwent a deepened cardiovascular system: hemodynamics local flow.
 Results. While studying there was increased general peripheric vascular resistance without normalization during follow-up period....

Relevance . Currently, researchers pay close attention to the study of chronic diseases that have a direct or indirect impact on state patient’s dental status. It is known inflammatory oral organs are, often simultaneously, permanent foci infection affect other systems and organs. The general list such includes: gingivitis, generalized periodontitis, glossitis, gingivostomatitis. Aim aim was effectiveness complex conservative therapy, including natural therapeutic factors Crimea, in patients...

Objective. An important role in the prevention of diseases, causative agents which are transmitted by ixodic ticks (tick-borne encephalitis, tick-borne borreliosis, human granulocytic anaplasmosis, monocytic erlichiosis) is assigned to non-specific measures. To prevent infection all pathogens these infections at same time, nonspecific preventive measures paramount importance. They include extermination hungry on vegetation relatively small areas natural biotopes, forest parks, health...