A5027521213- Advanced biosensing and bioanalysis techniques
- 2D Materials and Applications
- Cultural Heritage Materials Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Building materials and conservation
- Biosensors and Analytical Detection
- Electrospun Nanofibers in Biomedical Applications
- Conservation Techniques and Studies
- RNA Interference and Gene Delivery
- Perovskite Materials and Applications
- Silk-based biomaterials and applications
- MXene and MAX Phase Materials
- Hydrogels: synthesis, properties, applications
- Graphene research and applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Computational Drug Discovery Methods
- Carbon Nanotubes in Composites
- Lipid Membrane Structure and Behavior
- Boron and Carbon Nanomaterials Research
- Machine Learning in Materials Science
- Advanced Nanomaterials in Catalysis
- Spectroscopy and Quantum Chemical Studies
- Geomagnetism and Paleomagnetism Studies
- Optical Imaging and Spectroscopy Techniques
Marche Polytechnic University
2023-2025
University of Perugia
2022-2024
Sapienza University of Rome
2015-2023
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria
2019
Aberrant protein aggregation into amyloid fibrils underlies the onset of several degenerative pathologies, requiring increasing efforts to identify ever newer approaches prevent their formation and disassemble toxic structures. In this context, gold nanoparticles (AuNPs) show great promise, thanks ability chemically interact with proteins while simultaneously serving as local spectroscopic probes due peculiar optical properties. Here, we investigate role surface chemistry AuNPs in...
The exceptional photovoltaic properties of hybrid organic–inorganic perovskites have attracted increasing interest in the past decades. Among these materials, FAPbI3 shows two structural phases: high temperature perovskite α-phase, with direct bandgap close to Shockley–Queisser limit, and much less photoactive non-perovskite δ-phase, stable at ambient conditions. Although presence δ-phase has been usually regarded as a limitation for optoelectronic applications, recent studies found that...
Recent progress in nanotechnology and its application to biomedical settings have generated great advantages dealing with early cancer diagnosis. The identification of the specific properties cells, such as expression particular plasma membrane molecular receptors, has become crucial revealing presence assessing stage development disease. Here we report a single cell screening approach based on Surface Enhanced Raman Scattering (SERS) microimaging. We fabricated SERS-labelled nanovector...
The main protease (Mpro or 3CLpro) is an enzyme that evolutionarily conserved among different genera of coronaviruses. As it essential for processing and maturing viral polyproteins, Mpro has been identified as a promising target the development broad-spectrum drugs against Like SARS-CoV MERS-CoV, mature active form SARS-CoV-2 dimer composed identical subunits, each with single site. Individual monomers, however, have very low no catalytic activity. such, inhibition can be achieved by...
The mixing of Guanosine (Gua) and 5'-monophosphate (GMP) in water selected compositions yields highly hydrated, transparent, self-healing self-assembled supramolecular G-hydrogels, attractive for biomedical applications. This work investigates how hydrogel composition affects solute transport, including diffusion, binding, loading, release properties, using a set fluorescent probes with varying size polarity. Although small/wide-angle X-ray scattering techniques showed that no structural...
Telomeric G-quadruplexes (G4s) are promising targets in the design and development of anticancer drugs. Their actual topology depends on several factors, resulting structural polymorphism. In this study, we investigate how fast dynamics telomeric sequence AG3(TTAG3)3 (Tel22) conformation. By using Fourier transform Infrared spectroscopy, show that, hydrated powder state, Tel22 adopts parallel mixed antiparallel/parallel topologies presence K+ Na+ ions, respectively. These conformational...
Human telomeres (HTs) can form DNA G-quadruplex (G4), an attractive target for anticancer and antiviral drugs. HT-G4s exhibit inherent structural polymorphism, posing challenges understanding their specific recognition by ligands. Here, we aim to explore the impact of different topologies within a small segment HT (Tel22) on its interaction with BRACO19, rationally designed G4 ligand high quadruplex affinity, already employed in in-vivo treatments. Our multi-technique approach is based...
The phase diagram of correlated systems like cuprate or pnictide high-temperature superconductors is likely defined by a topological change the Fermi surface under continuous variation an external parameter, so-called Lifshitz transition. However, number low-temperature instabilities and interplay multiple energy scales complicate study this phenomenon. Here we identify optical signatures pressure-induced transition in clean elemental system, black phosphorus. By applying pressures above 1.5...
Vesuvius eruption that destroyed Pompeii in AD 79 represents one of the most important events history. The cataclysm left behind an abundance archeological evidence representing a fundamental source knowledge we have about ancient Roman material culture and technology. A great number textiles been preserved, rarely maintaining traces their original color, since they are mainly mineralized carbonized state. However, outstanding textile sample displays brilliant purple color gold strips. Since...
DNA/RNA synthesis precursors are especially vulnerable to damage induced by reactive oxygen species occurring following oxidative stress. Guanosine triphosphates the prevalent oxidized nucleosites, which can be misincorporated during replication, leading mutations and cell death. Here, we present a novel method based on micro-Raman spectroscopy, combined with ab initio calculations, for identification, detection, quantification of low concentrations nucleotides. We also show that Raman...
In this study, we fabricated adhesive patches from silkworm-regenerated silk and DNA to safeguard human skin the sun’s rays. The are realized by exploiting dissolution of fibers (e.g., fibroin (SF)) salmon sperm in formic acid CaCl2 solutions. Infrared spectroscopy is used investigate conformational transition SF when combined with DNA; results indicated that addition provides an increase crystallinity. UV–Visible absorption circular dichroism showed strong UV region presence B-form once...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes (G4s). These nanostructures have strong implications in many fields, from medical science to bottom-up nanotechnologies. As a result, ligands interacting with G4s attracted great attention as candidates therapies, molecular probe applications, and biosensing. In recent years, the use of G4-ligand complexes photopharmacological targets has shown significant promise for developing novel...
Due to the increasing tattoo practicing in Eastern countries and general concern on ink composition safety, green inks Green Concentrate by Eternal, for European "for Asia Market Only" were analyzed, under premise that only former falls a regulation. A separation of additives from pigment was carried out successive extraction solvents different polarities, i.e., water, acetone dichloromethane. The solid residues analyzed IR Raman spectroscopies, liquid fractions GC/mass spectrometry....