A5027279146- Influenza Virus Research Studies
- Rabies epidemiology and control
- Viral Infections and Outbreaks Research
- interferon and immune responses
- COVID-19 epidemiological studies
- Virology and Viral Diseases
- Poxvirus research and outbreaks
- Mathematical and Theoretical Epidemiology and Ecology Models
- RNA and protein synthesis mechanisms
- Bacillus and Francisella bacterial research
- vaccines and immunoinformatics approaches
- Animal Disease Management and Epidemiology
MRC University of Glasgow Centre for Virus Research
2022-2023
Roslin Institute
2022-2023
University of Edinburgh
2022-2023
Centre for Human Genetics
2022
Jenner Institute
2022
University of Oxford
2022
Rabies virus (RABV) causes lethal encephalitis and is responsible for approximately 60,000 deaths per year. As the sole virion-surface protein, rabies glycoprotein (RABV-G) mediates host-cell entry. RABV-G's pre-fusion trimeric conformation displays epitopes bound by protective neutralizing antibodies that can be induced vaccination or passively administered post-exposure prophylaxis. We report a 2.8-Å structure of RABV-G trimer in conformation, complex with two monoclonal antibodies, 17C7...
Interactions between viruses during coinfections can influence viral fitness and population diversity, as seen in the generation of reassortant pandemic influenza A virus (IAV) strains. However, opportunities for interactions closely related are limited by a process known superinfection exclusion (SIE), which blocks coinfection shortly after primary infection. Using IAVs, we asked whether SIE, an effect occurs at level individual cells, could limit populations they spread across multiple...
Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, typically hinders growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are recognised by cellular zinc-finger antiviral protein (ZAP), and so in principle, removing ZAP sensing from propagation system will reverse attenuation CpG-enriched virus, enabling high titre yield vaccine virus. We tested strain influenza A (IAV) engineered...
BackgroundRabies kills around 60 000 people each year. ChAdOx2 RabG, a simian adenovirus-vectored rabies vaccine candidate, might have potential to provide low-cost single-dose pre-exposure prophylaxis. This first-in-human study aimed evaluate its safety and immunogenicity in healthy adults.MethodsWe did single-centre phase 1 of administered as single intramuscular dose, with non-randomised open-label dose escalation at the Centre for Clinical Vaccinology Tropical Medicine, Oxford, UK....
Abstract Influenza viruses can interact during coinfections, allowing viral fitness to be altered by genome complementation and competition, increasing population diversity through reassortment. However, opportunities for these interactions are limited, as coinfection is blocked shortly after primary infection a process known superinfection exclusion (SIE). We asked whether SIE, which occurs at the level of individual cells, could limit within-host between populations influenza they spread...
Summary Rabies virus (RABV) causes lethal encephalitis and is responsible for approximately 60,000 deaths per year. As the sole virion-surface protein, rabies glycoprotein (RABV-G) mediates host-cell entry. RABV-G’s pre-fusion trimeric conformation displays epitopes bound by protective neutralizing antibodies which can be induced vaccination or passively administered post-exposure prophylaxis. We report a 2.8-Å structure of RABV-G trimer in conformation, complex with two monoclonal...
ABSTRACT Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, typically hinders growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are recognised by cellular zinc-finger antiviral protein (ZAP), and so in principle, removing ZAP sensing from propagation system will reverse attenuation CpG-enriched virus, enabling high titre yield vaccine virus. We tested strain influenza A (IAV)...