A5013502193- Synthesis and Characterization of Heterocyclic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- DNA and Nucleic Acid Chemistry
- HIV/AIDS drug development and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Fungal Plant Pathogen Control
- Bacteriophages and microbial interactions
- Biochemical and Molecular Research
- Cancer therapeutics and mechanisms
- Agriculture and Biological Studies
- Metal complexes synthesis and properties
- Toxin Mechanisms and Immunotoxins
- Bioactive Compounds and Antitumor Agents
- Bacterial Infections and Vaccines
- Herbal Medicine Research Studies
- Vibrio bacteria research studies
- Viral Infectious Diseases and Gene Expression in Insects
- Tuberculosis Research and Epidemiology
- Synthesis and pharmacology of benzodiazepine derivatives
- Cerebrospinal fluid and hydrocephalus
- Fungal Infections and Studies
- Phytochemical compounds biological activities
Institute of Molecular Biology and Genetics
2007-2024
National Academy of Sciences of Ukraine
2008-2024
UDC 577.152.3 + 615.32 Антивірусні влас ти вості рос лин них фла во ноїдівінгібіторів син те зу ДНК і РНК Л. Г. Паль чи ко вська 1 , О. В. Ва силь чен М. Пла то нов Д. Б. Ста ро си ла 2 Ю. І. Пор ва С. Ри мар П. Атаманюк Самійлен бал Інсти тут мо ле ку ляр ної біології ге не ки НАН Украї ни Вул.Академіка За бо лот но го
Keywords: 1,2,4-triazino[5,6-b][1,4]benzothiazines, design, virtual screening, synthesis, model transcription system
Keywords: N-arylamides 9-substituted PCA, model system of the DNA-dependent RNA-polymerase phage T7, antibacterial activity, antiviral activity
This paper presents the results of synthesis and study cytotoxicity anti-adenoviral activity new N4-derivatives 6-azacytidine its α-L-glycopyranosyl analogues obtained by simplified one-pot version silyl condensation method. The resulting acylated 4-methylmercapto-1,2,4-triazin-3(2Н)-one glycosides then underwent amination and/or ammonolysis to provide glycoside (2-6, 12, 15, 17) compounds with modifications at both base sugar fragments (11, 15). evaluation antiviral against AdV5 showed high...
The human genome is affected by diverse environmental pollution factors and this particularly acute for Ukrainians who have suffered from the Chernobyl radiation disaster. At same time many natural compounds, especially medicinal plants, are known as agents that prevent DNA lesions which often result in increasing mutagenesis carcinogenesis. aim of our work was to study DNA-protective potential biologically active compounds found Sambucus nigra called lectins, a very large group universally...
Aim.To evaluate a series of 2-substituted thiazolo [3,2-a]benzimidazolones as potential transcription inhibitors.Methods.Compounds were tested in model system based on T7 RNA polymerase.Results.The testing revealed number compounds able to inhibit at micromolar concentrations.The most active inhibitor was dihydroxy derivative BT29 with IC 50 = 1.6 mM.Conclusions. Structure-functional dependence the activity inhibitors found.The key structural feature required for their high is presence...
The search for substances possessing antiviral activities, in particular anti-influenza activity, is of importance designing new drugs that may be effective combating viral infections. the natural origin such as flavonoids and their derivatives are focus numerous studies. topical problem elucidation mechanisms interaction between flavonoid virus-specific targets infected cells. Aim. To assess activity flavonoid-enriched composition containing biologically active Proteflazidum against...
To study the mech a nisms of cytidine and its bi o log i cally ac tive an logues bind ing to DNA we lyzed these lig ands in pres ence well-known intercalator ethidium bro mide (EtBr).Thereto, have car ried out de tailed spec tro pho met ric re search EtBr-DNA mix tures ab sorp tion wide range wave lengths con cen tra tions.Cytidine riv tives tain aza group cy sine ring (6AZC, AZAfur AZAxyl) com pete with EtBr for sites.The stants site sizes ligand-DNA plexes were cal cu lated via op ti mi za...
цією з радіоактивними зондами показана ефективність поєднання вказаних підходів для аналізу розмірів та розподілу транскриптів індивідуальних генів між ядром
Сконструйованота синтезовано низку композитів на основі похідних феназин-1-карбонової кислоти та 6-азаураиилу, будову яких підтверджено методами УФ 1 Н-ЯМР спектроскопії.Неемпіричний (ab initio) квантовохімічний конформаційний аналіз рівні теорії HF/
Outer membrane vesicles (OMVs) carry various biomolecule cargo, including enzymes, and communicate with the surrounding via them.The role of enzyme-associated OMVs from food-grade bacteria in human health disease is not clear, particular, after impact stressful factors (changed gravity atmosphere, UV-radiation) context astronauts' diet.Aim.We researched Komagataeibacter oboediens isolated kombucha microbial community samples exposed to space/Mars-like stressors simulated on International...