A5010031638- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Neurofibromatosis and Schwannoma Cases
- Photochromic and Fluorescence Chemistry
- Photodynamic Therapy Research Studies
- RNA and protein synthesis mechanisms
- Nanoplatforms for cancer theranostics
- Metal complexes synthesis and properties
- DNA Repair Mechanisms
- Glioma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Spaceflight effects on biology
- RNA modifications and cancer
- Congenital heart defects research
- Biofield Effects and Biophysics
- Synthesis and Characterization of Heterocyclic Compounds
- Estrogen and related hormone effects
- Free Radicals and Antioxidants
- Synthesis of Tetrazole Derivatives
- Neuroblastoma Research and Treatments
- Genetic factors in colorectal cancer
- Crystallography and molecular interactions
- Tea Polyphenols and Effects
Justus-Liebig-Universität Gießen
2021-2024
Martin Luther University Halle-Wittenberg
2021-2023
Institute of Molecular Biology and Genetics
2016-2018
Taras Shevchenko National University of Kyiv
2017
Abstract Conventional photodynamic treatment strategies are based on the principle of activating molecular oxygen in situ by light, mediated a photosensitizer, which leads to generation reactive species and thereby causes cell death. A diarylethene‐derived peptidomimetic is presented that suitable for cancer therapy without any involvement oxygen. This light‐sensitive molecule not mediator but itself cytotoxic agent. As derivative cyclic amphiphilic peptide gramicidin S, exists two thermally...
Abstract Conventional photodynamic treatment strategies are based on the principle of activating molecular oxygen in situ by light, mediated a photosensitizer, which leads to generation reactive species and thereby causes cell death. A diarylethene‐derived peptidomimetic is presented that suitable for cancer therapy without any involvement oxygen. This light‐sensitive molecule not mediator but itself cytotoxic agent. As derivative cyclic amphiphilic peptide gramicidin S, exists two thermally...
A kombucha multimicrobial culture (KMC) was exposed to simulated Mars-like conditions in low Earth orbit (LEO). The study part of the BIOlogy and Mars EXperiment (BIOMEX), which accommodated European Space Agency's EXPOSE-R2 facility, outside International Station. aim investigate capability a KMC microecosystem survive LEO. During 18-month exposure period, desiccated samples, represented by living cellulose-based films, were subjected anoxic ultraviolet (UV) radiation, as prevalent at...
UvrD is a helicase vital for DNA replication and quality control processes. In its monomeric state, exhibits limited activity, necessitating either dimerization or assistance from an accessory protein to efficiently unwind DNA. Within the mismatch repair pathway, MutL plays pivotal role in relaying signal, enabling strand incision site up beyond mismatch. Although this interdependence well-established, precise mechanism of activation specific MutL-UvrD interactions that trigger activity...
We describe the generation of two human induced pluripotent stem cell (iPSC) lines derived from peripheral blood mononuclear cells (PBMCs) using a non-integrative episomal reprogramming strategy. The first line was NF1 patient with genetic variant c.1466A>G (BCRTi011-A) which leads to cryptic splice site and aberrant splicing. second one created healthy relative first-degree (BCRTi010-A). generated iPSC were shown have tri-lineage differentiation potential, normal karyotype, expression...
ABSTRACT We developed a sensitive, homogeneous fluorescence assay for the detection of DNA mismatches and damage based on mismatch repair (MMR) protein MutS. The is Förster resonance energy transfer (FRET) between SYBR Green I (SG), non-covalently bound to DNA, Alexa Fluor 647 (AF647) conjugated In contrast previous assays using only binding activity MutS, we exploited ATP-dependent loading multiple MutS sliding clamps provoked by mismatch/damage which increases overall sensitivity assay....