A5101838528- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Child Development and Digital Technology
- Family and Disability Support Research
- Vitamin D Research Studies
- Congenital heart defects research
- Vitamin C and Antioxidants Research
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Salivary Gland Disorders and Functions
- Pregnancy and preeclampsia studies
- Ocular Surface and Contact Lens
- Anesthesia and Neurotoxicity Research
- Corneal Surgery and Treatments
- Antioxidant Activity and Oxidative Stress
- Cannabis and Cannabinoid Research
- Growth Hormone and Insulin-like Growth Factors
- Sperm and Testicular Function
- Kruppel-like factors research
- Animal Virus Infections Studies
- Hydrogen's biological and therapeutic effects
- Ubiquitin and proteasome pathways
Zhejiang University
2012-2025
National Clinical Research
2025
Children's Hospital of Zhejiang University
2011-2024
Shanxi Agricultural University
2017-2019
Doheny Eye Institute
2004-2008
Ocular Surface Center
2008
University of Southern California
2004
Douglas Mental Health University Institute
2000
McGill University
2000
Dyslipidemia in pregnancy are associated with gestational diabetes mellitus (GDM), preeclampsia, preterm birth and other adverse outcomes, which has been extensively studied western countries. However, similar studies have rarely conducted Asian Our study was aimed at investigating the associations between maternal dyslipidemia outcomes among Chinese population.Data were derived from 934 pairs of non-diabetic mothers neonates 2010 2011. Serum blood samples assayed for fasting total...
Abstract Background Recent studies have suggested that vitamin D deficiency in children is widespread. But the status of Chinese seldom investigated. The objective present study was to survey serum levels 25-hydroxyvitamin [25(OH)D] more than 6,000 aged 1 month 16 years Hangzhou (latitude: 30°N), capital Zhejiang Province, southeast China. Methods who came child health care department our hospital, children's hospital affiliated university school medicine, for examination were taken blood...
<title>Abstract</title> Background Children with autism spectrum disorder (ASD) frequently presented weaker adaptive functioning compared typically developing children. Multiple affecting factors of in ASD individuals had been explored previous studies. Methods Data age, gender, parental education, place residence, behavioral intervention, attention deficit hyperactivity comorbidity, Wechsler Intelligence Scale for (WISC) scores and Autism Diagnostic Observation Schedule (ADOS) were...
In order to explore how existential psychological crises impact school rejection and dropout rates among Chinese teenagers, a mixed-methods approach is employed. Surveys on crises, purpose in life, motivation study are distributed, with 295 valid responses collected for analysis. In-depth interviews conducted gather qualitative data, allowing the individual experiences emotions of students be explored. Based quantitative research results, it was found that regression analysis existence...
Early detection of children with autism spectrum disorder (ASD) and comorbid intellectual disability (ID) can help in individualized intervention. Appropriate assessment diagnostic tools are lacking primary care. This study aims to explore the applicability machine learning (ML) methods diagnosing ASD ID compared traditional regression models.From January 2017 December 2021, 241 ASD, an average age 6.41 ± 1.96, diagnosed Developmental Behavior Department Children's Hospital Affiliated...
To evaluate the effect of viral IL-10 on lacrimal gland immunopathologic response in ocular surface disease, induced autoimmune dacryoadenitis.Disease was rabbits by injecting inferior glands with peripheral blood lymphocytes activated 5 days coculture autologous acinar cells a mixed-cell reaction. In treated group, an adenoviral vector carrying vIL-10 gene concurrently injected lymphocytes. Tears were collected periodically for quantitation ELISA. Two weeks after disease induction, tear...
Background . The objective of this study was to investigate the independent and combined effects maternal prepregnancy body mass index (BMI) gestational weight gain (GWG) on offspring growth at 0–3 years old. Methods A total 826 pairs nondiabetic mothers their were recruited in study. Maternal information abstracted from medical records questionnaires. Offspring trajectories weights BMIs depicted based anthropometric measurements. Results who overweight/obese or obtained excessive GWGs...
The present study was aimed at investigating the intelligence profiles and adaptive behaviors of children with high-functioning autism spectrum disorder (HFASD) developmental speech language disorders (DSLDs). We compared similarities differences cognitive capabilities functions explored their correlations in HFASD DSLDs groups. 128 patients HFASD, 111 114 typically developing (TD) were enrolled into our study. Wechsler Intelligence Scale for Children-IV (WISC-IV) Adaptive Behavior...
To investigate and compare the spatial temporal expression of post-synaptic density-95 (PSD-95) in Fmr1 knockout mice (the animal model fragile X syndrome, FXS) wild-type brain, on postnatal day 7 (P7), P14, P21, P28 P90, from each group were decapitated, three principal brain regions (cerebral cortex, hippocampus cerebellum) obtained stored for later experiments. PSD-95 mRNA areas was analyzed with quantitative RT-PCR. protein measured by immunohistochemical staining Western blot. In mice,...
Adaptive behaviour is closely related to quality of life in children with intellectual disability (ID), but little known about the adaptive fragile X syndrome (FXS) China.In boys FXS, behaviours six domains, including self-dependence, locomotion, work skills, communication, socialisation and self-management, were assessed by Infants-Junior Middle School Students Social-life Abilities Scale. In addition, we compared skills FXS those three control groups boys, Down (DS) typically developing...
Abstract Background Vitamin A can have a positive impact on growth and development of children, but vitamin deficiency (VAD) was found to be public health problem in Zhejiang Province, China 1998. There been no studies this topic Province recently. This study designed evaluate the serum retinol levels children aged 0~4 years southeast China. epidemiological data will help design supplementation strategies for high-risk groups improve their status. Methods Children were randomly recruited...
Cocaine- and amphetamine-regulated transcript (CART), discovered initially by via differential display RT-PCR analysis of brains rats administered cocaine, is expressed mainly in central nervous system or neuronal origin cells, involved a wide range behaviors, such as regulation food intake, energy homeostasis, reproduction. The hens egg-laying rate depends on the developmental status follicles, expression CART have not been identified from hen regulatory mechanisms biological activities are...
Abstract Background In previous study, we performed next-gene sequencing to investigate the differentially expressed transcripts of bovine follicular granulosa cells (GCs) at dominant follicle (DF) and subordinate (SF) stages during first wave. Present study is designed further identify key regulatory proteins signaling pathways associated with development using label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS) multi-omics data analysis approach. Methods DF SF from three...
Background: The ovarian follicle is an essential component of the reproductive process. It plays important role in controlling estrous cycle, determining behaviour, ensuring oocyte competency and subsequent embryo survival rate, both post ovulation corpus luteum function progesterone synthesis. Traditionally, gene expression studies field follicular development focus on study candidate genes interest. With next-generation sequencing technologies, transcriptome profiling has become a powerful...