A5030506417- Bacteriophages and microbial interactions
- Lipid metabolism and disorders
- Plant-Microbe Interactions and Immunity
- Cancer, Lipids, and Metabolism
- Respiratory viral infections research
- Influenza Virus Research Studies
- Lipoproteins and Cardiovascular Health
- Birth, Development, and Health
- Legume Nitrogen Fixing Symbiosis
- Plant Pathogenic Bacteria Studies
Union Hospital
2022
Huazhong University of Science and Technology
2022
Chinese Academy of Agricultural Sciences
2021
Institute of Crop Sciences
2021
University of Toledo
2020
A one-/two-dimensional genome-wide association study (GWAS) strategy was adopted to investigate the genetic systems underlying reciprocal adaptation of rice (Oryza sativa) and its bacterial pathogen, Xanthomonas oryzae pv. (Xoo) using whole-genome sequencing large-scale phenotyping data 701 accessions 23 diverse Xoo strains. Forty-seven virulence-related genes 318 quantitative resistance (QR-genes) mainly located in 41 genomic regions, interactions between detected QR-genes were identified,...
To read the full abstract: Endocrinology vol. 161,2 (2020): bqz041. doi: https://academic.oup.com/endo/article/161/2/bqz041/5698115
家族性高胆固醇血症（FH）是一种常见遗传病，以低密度脂蛋白胆固醇（LDL-C）水平升高为特征，伴早发动脉粥样硬化性心血管疾病。该文报道FH的一家系，先证者系12岁女性患者，血浆LDL-C异常升高、有黄色瘤且早发冠心病，符合纯合子FH（HoFH）或复合杂合子FH（CHeFH）的临床表现。采用下一代测序技术对该家系成员进行遗传筛查，发现先证者携带LDLR基因的无义变异LDLR：c.1257C>G/p.Tyr419Ter和错义变异LDLR：c.1879G>A/p.Ala627Thr，分别源于其父母，符合CHeFH。先证者的父母、同胞兄弟和舅舅是FH的杂合子（HeFH）患者。基于遗传学诊断，个体化地给予该家系内每个患者他汀类药物、依折麦布和前蛋白转化酶枯草溶菌素9型（PCSK9）抑制剂治疗。先证者接受肝移植，接受冠状动脉支架置入。.