A5073816289- Photosynthetic Processes and Mechanisms
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Light effects on plants
- Parasites and Host Interactions
- CRISPR and Genetic Engineering
- Genetics and Neurodevelopmental Disorders
- DNA Repair Mechanisms
- Parasite Biology and Host Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Helminth infection and control
University of Pittsburgh
2018-2023
Magee-Womens Research Institute
2021
Centro Uruguayo de Imagenología Molecular
2018
Abstract Aurora A kinase (AURKA) is a master cell-cycle regulator that often dysregulated in human cancers. Its overexpression has been associated with genome instability and oncogenic transformation. The protein D (PKD) family an emerging therapeutic target of cancer. Aberrant PKD activation implicated tumor growth survival, yet the underlying mechanisms remain to be elucidated. This study identified, for first time, functional crosstalk between PKD2 cancer cells. data demonstrate...
In vivo monitoring of gpdh-1 gene expression using standard transcriptional reporters is a powerful and commonly used tool for genetic dissection the osmotic stress response in C. elegans . Like all transgene reporters, these have important limitations that restrict their utility. To overcome limitations, we created three different CRISPR/Cas9 methods to insert several variants GFP into endogenous locus. These new strains provide more accurate analysis regulatory pathways.