A5012429566- Dermatologic Treatments and Research
- Laser Applications in Dentistry and Medicine
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Redox biology and oxidative stress
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Optical Coherence Tomography Applications
- Systemic Sclerosis and Related Diseases
- Sirtuins and Resveratrol in Medicine
- Medical and Biological Ozone Research
- Cutaneous Melanoma Detection and Management
- Skin and Cellular Biology Research
- Wound Healing and Treatments
- Fibroblast Growth Factor Research
- MicroRNA in disease regulation
- Silymarin and Mushroom Poisoning
- Ocular and Laser Science Research
- melanin and skin pigmentation
- Apelin-related biomedical research
- Hidradenitis Suppurativa and Treatments
- Berberine and alkaloids research
- Autoimmune Bullous Skin Diseases
- Skin Diseases and Diabetes
- Herbal Medicine Research Studies
SUNY Downstate Health Sciences University
2014-2021
Kaiser Permanente Modesto Medical Center and Medical Offices
2021
State University of New York
2014-2020
University of California, Davis
2013-2019
Sacramento VA Medical Center
2013-2018
California Pacific Medical Center
2016-2017
University of California Davis Medical Center
2013
University of California, Merced
2009
Blue light is part of the visible spectrum that does not generate harmful DNA adducts associated with skin cancer and photoaging, may represent a safer therapeutic modality for treatment keloid scars other fibrotic diseases. Our laboratory previously demonstrated light-emitting diode (LED) red infrared inhibits proliferation fibroblasts. Moreover, different wavelengths can produce biological effects. Furthermore, effects LED blue (LED-BL) on human fibroblasts are well characterized. This...
Red light is part of the visible spectrum. The effects light-emitting diode (LED)-generated red on human skin are not well-characterized.To study effect LED-generated low-level therapy (LLLT) fibroblast proliferation and viability in vitro.Irradiation normal fibroblasts using LED panels was performed vitro, modulation quantified trypan blue dye exclusion assay.Statistically significant decreases cell were noted at following fluences (time): 160 J/cm2 (30 minutes, 34 seconds), 320 (61 07...
Actinic keratoses (AKs) are generally accepted as common precursor lesions to invasive squamous cell carcinoma. Photodynamic therapy (PDT) is a common, in-office, field modality used in the treatment of AKs. Clinical and laboratory observations have demonstrated that temperature modulation can affect PDT efficacy.To demonstrate thermal increases apoptotic death, investigate mechanistic role reactive oxygen species (ROS) free radicals an vitro human skin fibroblast model.This study was...
Skin fibrosis, often referred to as skin scarring, is a significant international health problem with limited treatment options. The hallmarks of fibrosis are increased fibroblast proliferation, collagen production, and migration speed. Recently published clinical observations indicate that visible red light may improve fibrosis. In this study we hypothesize high‐fluence light‐emitting diode‐generated (HF‐LED‐RL) modulates the key cellular features by decreasing speed human fibroblasts....
Red light is part of the visible spectrum that does not generate DNA adducts associated with skin cancer and photoaging may represent a safer therapeutic modality for treatment keloid scars other fibrotic diseases. Our laboratory previously demonstrated light-emitting diode-generated red (LED-RL) inhibits proliferation fibroblasts. The effects LED-RL on keloidal are well characterized.To determine effect keloid-derived fibroblast viability in vitro.Irradiation primary human fibroblasts using...
Field cancerization describes the phenomenon that multiple heterogenous mutations may arise in an area exposed to chronic carcinogenic stimuli. Advances understanding of cutaneous field have led novel therapeutic approaches management actinic keratoses (AKs). Herein, we review literature on pathophysiology and emerging research dermatology. The classification systems for grading AK lesions are being refined with investigations focusing their clinical utility. There is a growing shift toward...
Abstract Therapeutic applications of light emitting diode‐red (LED‐RL) are expanding, yet data on its clinical effects lacking. Our goal was to evaluate the safety high fluence LED‐RL (≥160 J/cm 2 ). In two phase I, single‐blind, dose escalation, randomized controlled trials, healthy subjects received or mock irradiation forearm thrice weekly for 3 weeks at fluences 160‐640 all skin types (STARS 1, n = 60) and 480‐640 non‐Hispanic Caucasians 2, 55). The primary outcome incidence adverse...
Abstract Fibrosis occurs when collagen deposition and fibroblast proliferation replace healthy tissue. Red light (RL) may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near-infrared undergo photophysical reactions. Our previous research demonstrated that high fluence RL reduces proliferation, deposition, migration. Despite identification of several cellular mechanisms underpinning phototherapy, little is known about...
Light-emitting diode-generated blue light (LED-BL) is part of the visible spectrum that does not cause DNA damage and may represent a safer alternative to ultraviolet phototherapy. Previous research demonstrated LED-BL can inhibit adult human skin fibroblast proliferation migration speed associated with increased reactive oxygen species (ROS) generation in dose-dependent manner. In addition, resveratrol possesses potent intracellular antioxidative effects on ROS-free radicals fibroblasts.The...
Scarring has significant esthetic and functional consequences for patients. A need exists anti-scarring therapeutics. Light emitting diode-red light (LED-RL) been shown to modulate skin fibrosis. The aim of this study is evaluate the safety efficacy LED-RL reduce post-operative scarring. Cutaneous Understanding Red-light Efficacy on was a randomized, mock-controlled, single-blind, dose-ranging, split-face phase II clinical trial. Starting 1 week post-surgery, patients received irradiation...
BACKGROUND Skin fibrosis is a debilitating condition that significantly impacts patient quality of life. Ultraviolet phototherapy currently used to treat several diseases featuring skin fibrosis. High-fluence light-emitting diode–generated red light (HF-LED-RL) does not cause DNA damage associated with cancer, and it generally regarded as safe, portable, cost-effective. Early clinical observations suggest LED-generated may possess antifibrotic effects, although these findings are largely...
Skin fibrosis is a chronic debilitating feature of several skin diseases that lead to characteristic increases in dermal fibroblast proliferation and collagen deposition through upregulation components the transforming growth factor beta (TGF‐B)/SMAD pathway. In contrast ultraviolet phototherapy, high‐fluence light‐emitting diode‐generated red light (HF‐LED‐RL, 633 ± 15 nm) safe, economic non‐invasive therapy with vitro evidence supports modulation key cellular characteristics involved...