A5019172906- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Protease and Inhibitor Mechanisms
- Blood Pressure and Hypertension Studies
- Cardiac Fibrosis and Remodeling
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Blood Coagulation and Thrombosis Mechanisms
- Peptidase Inhibition and Analysis
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Hormonal Regulation and Hypertension
- Health Systems, Economic Evaluations, Quality of Life
- Acute Ischemic Stroke Management
- Angiogenesis and VEGF in Cancer
- Cerebrovascular and Carotid Artery Diseases
- Inflammatory Biomarkers in Disease Prognosis
Leeds Teaching Hospitals NHS Trust
2016-2025
Leeds General Infirmary
2015-2025
University of Leeds
2014-2025
University of Leicester
2022
Institute of Cardiology
2020
Università Cattolica del Sacro Cuore
2017
St Bartholomew's Hospital
2010-2015
Barts Health NHS Trust
2009-2011
University of Birmingham
2011
Imperial College Healthcare NHS Trust
2010
Background:Hypertension results in structural changes to the cardiac and vascular extracellular matrix (ECM). Matrix metalloproteinases (MMP) their inhibitors (TIMP) may play a central role modulation of this matrix. We hypothesized that both MMP-9 TIMP-1 would be abnormal hypertension, reflecting alterations ECM turnover, circulating levels should linked cardiovascular (CHD) stroke (CVA) risk scores using Framingham equation. Second, we treatment result indices.
Catheter ablation of paroxysmal AF using the Cryoballoon (CRYO) has yielded similar success rates to conventional wide encirclement radiofrequency catheter (RFCA), but randomized data are lacking. Pilot suggested a high rate with combined approach (COMBINED) RFCA followed by 2 CRYO applications each vein. We compared these 3 strategies in controlled trial.Patients undergoing first time were RFCA, CRYO, or COMBINED. Patients up at 3, 6, and 12 months 7 days ambulatory ECG monitoring. Success...
Background. There is increased platelet activation in many cardiovascular diseases. This observation may explain the presence of levels microparticles (PMP) these However, whether or not PMPs inter‐relate with other markers activation, such as soluble P‐selectin, disease severity, unknown. We therefore hypothesized raised PMP stable peripheral artery (PAD) intermittent claudication (IC), an additional increase severe PAD critical limb ischaemia (CLI). Furthermore, we tested hypothesis that...
Whether ablation of complex fractionated atrial electrograms (CFAE) modifies fibrillation (AF) by eliminating drivers or debulking remains unknown. This randomized study aimed to determine the effect ablating different CFAE morphologies compared with normal (ie, tissue) on cycle length persistent AF (AFCL).After pulmonary vein isolation left and right were targeted, until termination abolition before DC cardioversion. Ten-second classified according a validated scale, grade 1 being most 5...
Previous studies indicate that South Asians (SAs) may have a reduced risk of developing atrial fibrillation (AF) despite having higher prevalence traditional cardiovascular factors. This observational study was designed to explore the relative differences between SAs and Whites in well-defined, multi-ethnic population with careful consideration factors are thought contribute development AF. Anonymized data from 417 575 adults were sourced primary care records within Bradford Metropolitan...
Transient loss of consciousness is a common presentation to emergency departments, medical assessment units, and cardiology neurology outpatients. It frequently resulting in hospital admission, or multiple presentations health services up third cases specific aetiology not identified. [D'Ascenzo F, Biondi-Zoccai G, Reed MJ, Gabayan GZ, Suzuki M, Costantino et al. Incidence, etiology predictors adverse outcomes 43,315 patients presenting the Emergency Department with syncope: an international...
The commonest cause of mortality in patients with Type 2 diabetes is atherothrombosis, which can be related to abnormalities the coagulation and fibrinolytic pathways, as well platelet function. Platelet microparticles (PMPs) may contribute prothrombotic state promote progression atherosclerosis. We hypothesized that PMPs are elevated clinically apparent atherosclerosis would have highest levels. Similarly, we soluble plasma P-selectin (sPsel) CD40L (both molecules released by activated...
Hypertension, hypertensive heart disease, and left ventricular (LV) hypertrophy are integral to symptomatic diastolic failure. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is linked extracellular matrix fibrosis elevated in hypertension. We hypothesized a link between circulating TIMP-1, metalloproteinase-9 (MMP-9), resting echocardiographic LV filling parameters using tissue Doppler (dys)function.Circulating MMP-9 TIMP-1 levels were measured citrated plasma by ELISA 74 patients with...
AimsWe hypothesized that modulation of the renin–angiotensin–aldosterone system (RAAS) improves success following catheter ablation for atrial fibrillation (AF).
Abstract Aims Although cryoballoon pulmonary vein isolation is a well-established treatment for paroxysmal atrial fibrillation (AF), it’s role in persistent AF unclear. We examined procedural success and long-term outcomes of cryoablation longstanding AF. Methods results International multicentre registry from three UK eight European centres. Consecutive patients undergoing included. Procedural data, complications, follow-up were prospectively recorded. Patients followed-up at 3, 6, 12...
Aims To test the ability of four circulating biomarkers fibrosis, and low left atrial voltage, to predict recurrence fibrillation after catheter ablation. Background Circulating potentially may be used improve patient selection for Low voltage areas in atrium arrhythmia when mapped sinus rhythm. This study tested type III procollagen N terminal peptide (PIIINP), galectin-3 (gal-3), fibroblast growth factor 23 (FGF-23), I collagen C telopeptide (ICTP), whether predicted recurrence,...
Handheld electrocardiogram (ECG) monitors are increasingly used by both healthcare workers and patients to diagnose cardiac arrhythmias. There is a lack of studies validating the use handheld devices against standard 12-lead ECG. The Kardia 6L novel ECG monitor which can produce 6-lead In this study, we compare ECG.A prospective study consisting unselected inpatients outpatients at Leeds Teaching Hospital NHS Trust. All participants had 12- ECGs. parameters were analysed using method...
Peripheral arterial disease (PAD) is associated with adaptive changes in the vascular and muscle extracellular matrix (ECM) response to reduced blood flow. Matrix metalloproteinases (MMPs) their inhibitors (TIMPs), are key modulators of ECM turnover. We hypothesized that patients intermittent claudication (with low ankle-brachial pressure index, <0.8), critical ischaemia would have raised circulating levels MMP-9, TIMP-1 TIMP-2 compared healthy controls, reflecting an increase proteolytic...