A5054172225- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Drug-Induced Ocular Toxicity
- Retinal and Optic Conditions
- Organ and Tissue Transplantation Research
- Systemic Lupus Erythematosus Research
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Peripheral Neuropathies and Disorders
- Biomedical Ethics and Regulation
- Multiple Sclerosis Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Blood groups and transfusion
- Tissue Engineering and Regenerative Medicine
- Social and Demographic Issues in Germany
- Vasculitis and related conditions
- Ophthalmology and Eye Disorders
- Genetic Neurodegenerative Diseases
- Medical and Health Sciences Research
- Histiocytic Disorders and Treatments
Charité - Universitätsmedizin Berlin
2014-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2024
Humboldt-Universität zu Berlin
2018-2024
Freie Universität Berlin
2018-2024
Christie's
2014
Volkswagen Foundation
2014
Ophthalmology Clinic
2009-2012
Centre Virchow-Villermé
2012
Institute for Transfusion Medicine
2011
Ophthalmology Associates (United States)
2011
Evaluating the Predictability of Postoperative Target Refraction Using Prototype a New Intraoperative Aberrometer
Background Autosomal dominant spinocerebellar ataxia type 1 is an adult onset progressive disorder with well characterized neurodegeneration in the cerebellum and brainstem. Beyond brain atrophy, few data exist concerning retinal optic nerve involvement. Objective To evaluate changes SCA1 patients compared to age gender matched healthy controls. Methodology/Principal Findings Nine were prospectively recruited from clinic nine Both cohorts received assessment of visually evoked potentials eye...
BACKGROUND/AIMS A computer program for the automatic estimation of endothelium morphometric parameters (cell density, pleomorphism, polymegethism) in alizarine red-stained images is presented and evaluated. METHODS Images corneal from 30 porcine eyes stained with red were acquired an optical microscope saved as grey-level digital images. Each image was first pre-processed luminosity correction contrast enhancement. An artificial neural network used to classify all pixels cell contour or body...
<h3>Objective:</h3> One mechanism underlying the link between multiple sclerosis (MS) and Epstein-Barr virus (EBV) might be a direct CNS infection. Viral infections cause elevated antibody indices (AIs). Elevated EBV AIs were found in MS; however, patients with MS frequently show polyspecific intrathecal immune response antiviral AIs. To discriminate whether indicate virus-driven or response, we determined fraction of anti-EBV antibodies. <h3>Methods:</h3> The intrathecally synthesized...
Abstract Purpose To investigate pathomechanisms involved in graft detachment after Descemet's membrane endothelial keratoplasty ( DMEK ) and its clinical implications. Methods In a prospective case series, 30 eyes with Fuchs' dystrophy underwent . Intraoperatively obtained recipients' endothelium‐Descemet's membranes EDMs were investigated histologically immunohistochemically. The postoperative donor status was categorized as attached or detached. Clinical morphological parameters analysed...
<h3>Background/Aims</h3> To evaluate risk factors for retinal damage due to the intake of chloroquine and hydroxychloroquine. <h3>Methods</h3> In a retrospective chart review, patients receiving or having received one drugs were classified as affected by maculopathy retinopathy, not on basis documented findings. Uncertain cases excluded. The postulated American Academy Ophthalmology (AAO) additional like diagnosis underlying disease, total dose, nicotine abuse sum AAO compared between both...
To evaluate clinical outcomes and complications after Descemet membrane endothelial keratoplasty (DMEK) in a child.A 12-year-old boy with Kearns-Sayre syndrome (chronic progressive external ophthalmoplegia, cardiac conduction block, pigmentary retinal degeneration) corneal dysfunction was successfully treated DMEK. Corneal transparency, central thickness (CCT), cell density (ECD), visual outcomes, complication rates were measured during the follow-up of 6 months.Best spectacle-corrected...
Die Sektion Gewebetransplantation und Biotechnologie der Deutschen Ophthalmologischen Gesellschaft (DOG) publiziert seit 2009 regelmäßig die freiwillig angegebenen Leistungszahlen assoziierten Augenhornhautbanken [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]. Seit 2016 sind 26 in organisiert ([Tab. 1]).
Since blood culture bottles are validated by the manufacturer for only, an additional validation use with fluids of tissue preparations is necessary.Two 10-ml samples cornea medium, histidine-tryptophan-ketoglutarate (HTK) solution, or Ringer solution at end femur head thermo-disinfection were given into (BD BACTEC™ Plus Aerobic/F, Anaerobic/F medium and BD Standard Aerobic/Anaerobic HTK solution) subsequently spiked 10-100 colony forming units (CFU) bacteria fungi (aerobic bacteria:...
Purpose: To evaluate the feasibility and cut quality of corneal trephination in human donor tissue with femtosecond laser. Methods: Twelve corneoscleral discs were inserted an artificial anterior chamber. After thickness measurement tonometry, cornea was mounted on a laser (FEMTEC; 20/10 Perfect Vision, Heidelberg, Germany) through contact lens (patient interface). Trephination performed diameters 7.0, 7.5, 8.0, 8.5 mm 3 corneas each. The button removed from disc 2 each case. not manipulated...
Background: Some properties of blood are modified post mortem. These modifications might give false-negative or false-positive results in infectious disease testing. Most CE-marked test equipment for serology testing is not validated post-mortal blood. Validation, however, obligatory, if the used release tissues transplantation. Methods: Samples pre- and post-mortem sera were obtained from 20 cornea donors, compared anti-HIV-1/2, anti-HCV, HBsAg, anti-HBc on Siemens-BEP-III Automatic System....
The management of graft failure is increasingly relevant with the spread and growing acceptance endothelial keratoplasty.To investigate functional anatomical results secondary Descemet membrane keratoplasty (DMEK) for after stripping (DSEK) to histologically analyze stroma-to-stroma interface respect clinical implications.In a single-surgeon prospective comparative case series at Department Ophthalmology, Charité-University Medicine Berlin, Germany, 8 eyes (3.8%) 210 consecutively performed...
To investigate functional and anatomical results up to 12 months after Descemet's membrane endothelial keratoplasty (DMEK) for Fuchs' dystrophy (FED) versus bullous keratopathy (BK) in consideration of morphologic characteristics on host's endothelium-Descemet's membranes (EDM).In a prospective consecutive case series, 119 eyes underwent primary DMEK FED or BK. Intraoperatively obtained EDM were investigated immunohistologically. Clinical morphological parameters compared between BK.Overall,...
Zusammenfassung Die Sektion Gewebetransplantation und Biotechnologie der Deutschen Ophthalmologischen Gesellschaft (DOG) legt ihren 11. Leistungsbericht des Jahres 2021 vor. Anzahl eingeworbenen Augenhornhäute ist im Vergleich zu den Vorjahren leicht ansteigend. Dennoch besteht immer noch ein Bedarf für Import aus dem Ausland, somit Transplantatengpass nicht beseitigt.
CORNEAS NEEDED FOR KERATOPLASTY CAN BE HARVESTED USING TWO TECHNIQUES: whole globe enucleation and in situ excision of the corneoscleral disc. This study evaluates rate microbial contamination donor cornea organ culture medium according to method retrieval.All corneas our bank received between January 1, 2001 December 31, 2009 put into microbio-logically tested were prospectively analyzed for medium.2,805 could be included this total. 975 them retrieved by (group 1) 1,830 disc 2). 15 group 1...
Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane (DMEK) have become well established procedures for the treatment of pathologies. In last years field lamellar corneal surgery has further developed in terms preparation lamellae as implantation.A modified form "ultrathin DSAEK" (UT-DSAEK) is "microkeratome excimer laser-assisted keratoplasty" (MELEK). this new technique a graft prepared by single cut microkeratome followed stromal excimer-laser thinning...
Introduction Since the beginning of COVID-19 pandemic there has been some debate regarding risk transmission through tissue transplantation and banking processes.