A5006875105- Synthesis and Biological Evaluation
- Environmental Toxicology and Ecotoxicology
- Synthesis and Reactions of Organic Compounds
- Chemical Reaction Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Microplastics and Plastic Pollution
- Toxic Organic Pollutants Impact
- Synthesis of heterocyclic compounds
- Mercury impact and mitigation studies
- Quinazolinone synthesis and applications
- Recycling and Waste Management Techniques
- Heavy metals in environment
- Pharmaceutical and Antibiotic Environmental Impacts
- Rheumatoid Arthritis Research and Therapies
- Marine Biology and Environmental Chemistry
- Chemistry and Chemical Engineering
- Histone Deacetylase Inhibitors Research
- Systemic Lupus Erythematosus Research
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Axon Guidance and Neuronal Signaling
- Inflammatory Bowel Disease
- Synthesis and Reactivity of Heterocycles
Instituto Español de Oceanografía
2012-2024
Centro Oceanográfico de Murcia
2010-2023
Galicia Sur Biomedical Foundation
2023
University Medical Center Utrecht
2016-2022
Utrecht University
2022
University of Amsterdam
2014-2018
Amsterdam UMC Location University of Amsterdam
2014-2018
ArcelorMittal (Spain)
2015
Loughborough University
2015
Center for Rheumatology
2013
Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated anti-inflammatory properties in both vitro and vivo models of rheumatoid arthritis (RA). Here, we investigated the potential contribution specific class I IIb HDACs to inflammatory gene expression RA fibroblast-like synoviocytes (FLS).RA FLS were incubated with pan-HDACi (ITF2357, givinostat) or selective HDAC1/2i, HDAC3/6i, HDAC6i HDAC8i. Alternatively, transfected HDAC3, HDAC6 interferon (IFN)-α/β receptor alpha...
Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis prototypic fibrotic disease in which CXCL4 increased strongly correlates with skin lung fibrosis. Here we aim to elucidate the role fibrosis development. levels are multiple inflammatory mouse models, and, using CXCL4-deficient mice, demonstrate essential promoting events skin, lungs, heart. Overexpressing human mice aggravates, whereas...
<h3>Background</h3> Lumbosacral transitional vertebra can result in an anomalous number of lumbar vertebrae associated with wrong level treatment. The primary aim this study was to characterize discrepancies between reported referring levels and from MRI reports treated levels. secondary analyze interobserver variability a pain physician radiologist when determining classifying lumbosacral vertebrae. <h3>Methods</h3> Between February 2016 October 2019, retrospective case series prospectively...
Angiopoietin (Ang) -1 and -2 their receptor Tie2 play critical roles in regulating angiogenic processes during development, homeostasis, tumorigenesis, inflammation tissue repair. signaling is best characterized endothelial cells, but a subset of human murine circulating monocytes/macrophages essential to solid tumor formation express display immunosuppressive properties consistent with M2 macrophage polarization. However, we have recently shown that strongly activated pro-inflammatory...
Diagnosis of complex disease and response to treatment is often associated with multiple indicators, both clinical laboratorial. With the use biomarkers, various mechanisms have been unraveled which can lead better faster diagnosis, predicting monitoring new drug development. introduction multiplex technology for immunoassays growing awareness role immune-monitoring during therapeutic interventions it now possible test large numbers soluble mediators in small sample volumes. However,...
SSc is an autoimmune disease characterized by inflammation, vascular injury and excessive fibrosis in multiple organs. Secreted protein acidic rich cysteine (SPARC) a matricellular glycoprotein that regulates processes involved pathology, such as inflammation fibrosis. In vivo vitro studies have implicated SPARC SSc, but it unclear if the pro-fibrotic effects of on fibroblasts are result intracellular signalling or fibroblast interactions with extracellular hampering further development...
Abstract Environmental genotoxicity and cytotoxicity along the Spanish Mediterranean coast was investigated through determination of levels micronuclei (MN) other nuclear abnormalities (NAs) such as buds (NB) binucleated cells (BN) in gills wild mussels, Mytilus galloprovincialis , from 17 study sites. The results obtained were studied relation to exposure main pollutants (metals, PAHs, PCBs DDTs), gill antioxidant enzyme activities environmental variables (temperature salinity). highest MN...
Class 3 semaphorins regulate diverse cellular processes relevant to the pathology of RA, including immune modulation, angiogenesis, apoptosis and invasive cell migration. Therefore, we analysed potential role class in RA.Protein mRNA expression RA synovial tissue, SF fibroblast-like synoviocytes (FLS) were determined by immunoblotting quantitative PCR (qPCR). FLS migration invasion using wound closure transwell assays, respectively. PlexinA1, neuropilin-1 neuropilin-2 was knocked down small...
Lately, the role of microplastics (MP) as vectors for dissolved contaminants and vehicle their transfer to aquatic organisms has received attention. Similarly MP, other inorganic organic particles may act passive samplers. However, limited comparative knowledge exists at this respect. In present study we have comparatively investigated risk mussel MP pesticide chlorpyrifos (CPF) alone in combination with phytoplankton microalgae (MP-CPF MA-CPF, respectively). We selected similar size expose...
Abstract Kinetic studies on the Hinsberg condensation were performed trying to improve yields and achieve regio‐selectivity in attainment of benzene‐substituted 3‐methylquinoxalin‐2(1 H )‐ones. The course reactions between o ‐phenylenediamine ( ‐PDA) substituted ‐PDA with pyruvic acid 2a ) or ethyl pyruvate 2b followed by uv spectrophotometry at different p values. formation )‐one 6a was improved using sulphuric acid‐water mixtures, which reaction proceeded a mechanism....