A5071367947- Synthesis and Biological Evaluation
- X-ray Diffraction in Crystallography
- Trypanosoma species research and implications
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Research on Leishmaniasis Studies
- Viral Infections and Immunology Research
- Receptor Mechanisms and Signaling
- Insect Pest Control Strategies
- Asymmetric Synthesis and Catalysis
- Plant biochemistry and biosynthesis
- Computational Drug Discovery Methods
- Molecular spectroscopy and chirality
- Click Chemistry and Applications
- Neuropeptides and Animal Physiology
- Dyeing and Modifying Textile Fibers
- Protein Degradation and Inhibitors
- Toxin Mechanisms and Immunotoxins
- Electrochemical Analysis and Applications
- Coordination Chemistry and Organometallics
- Plant Toxicity and Pharmacological Properties
- Photochemistry and Electron Transfer Studies
- Protein Kinase Regulation and GTPase Signaling
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2024
University of Buenos Aires
2014-2024
Instituto de Química y Fisicoquímica Biológicas
2015-2024
HUN-REN Research Centre for Natural Sciences
2000
ABSTRACT In the present work, we described activity of thiosemicarbazone derived from 5,6-dimethoxy-1-indanone (TSC), which previously characterized as a new compound that inhibits bovine viral diarrhea virus (BVDV) infection. We showed TSC acts at point time coincides with onset RNA synthesis and it BVDV replication complexes (RCs). Moreover, have selected five mutants turned out to be highly resistant but still susceptible ribavirin (RBV). Four these carried an N264D mutation in...
The sesquiterpene lactones eupatoriopicrin, estafietin, eupahakonenin B and minimolide have been isolated from Argentinean Astearaceae species found to be active against Trypanosoma cruzi epimastigotes. aim of this work was evaluate the activity these compounds by analyzing their effect stages parasites that are infective for human. Even more interesting, we aimed determine most selective compound on an in vivo model T. infection. Eupatoriopicrin amastigotes tripomastigotes (IC50 = 2.3...
A rapid and efficient protocol assisted by microwave irradiation for the synthesis of esters using methanesulfonic acid (CH3SO3H) supported on Al2O3 (AMA) as catalyst free solvent is described. The products were obtained in good yields purity, with reduced reaction time, process simple environmentally benign.
A serie of N-acetyl phenothiazines and related compounds was synthesized by means the acetylation reaction corresponding phenothiazine with appropriate reagent using microwave irradiation. Structural elucidation these heterocyclic derivatives done 1H, 13C NMR spectra. The equilibra between conformationals enantiomers were studied as a possible atropisomerism case. single crystal X-ray diffraction some also recorded presence could be confirmed. antifungal activity evaluation all prepared us...
Metabolic clearance of isoniazid (INH) may be up to 10 times faster in individuals who are rapid acetylators compared with slow acetylators. In addition, the acetylation phenotype has been suggested change age. A better knowledge age distribution genotype and children requiring INH for tuberculosis treatment or prevention could important optimize safety efficacy use.The aim present study was evaluate NAT2 an Argentinean pediatric population rom Buenos Aires. we wanted describe...
We present for the first time a study at molecular level of the<italic>T. cruzi</italic>SE and structural requirements its inhibition.
The sesquiterpene lactones cumanin, helenalin, and hymenin their semisynthetic derivatives were evaluated against Trypanosoma cruzi epimastigotes. cytotoxicity of the compounds was on murine splenocytes. Cumanin diacetate one most active selective [IC50 = 3.20 ± 0.52 μg/mL, selectivity index (SI) 26.0]. This lactone selected for its evaluation trypomastigote amastigote forms parasite. diacetylated derivative cumanin showed moderate activity trypomastigotes (IC50 32.4 5.8 μg/mL). However,...
Lithraea molleoides (Anacardiaceae) is a tree that grows in South America including Southern Brazil, Southern, and Eastern Bolivia, Paraguay, Northern, Central Argentina. Infusions, decoctions, or tinctures from its aerial parts (leaves, buds, young stems) are employed ethnomedicine mainly against respiratory, digestive inflammations illnesses. Antibacterial, antiviral, antioxidant, anti-inflammatory, antinociceptive activities, among others, have been reported for L. molleoides. Many of...
Abstract G protein‐coupled receptors kinase 2 (GRK2) plays a major role in receptor regulation and, as consequence, cell biology and physiology. GRK2‐mediated desensitization is performed by its domain, which exerts phosphorylation promoting protein uncoupling the cessation of signaling, RGS homology (RH) able to interrupt signaling. Since GRK2 activity exacerbated several pathologies, many efforts develop inhibitors have been conducted. Most them were directed toward showed encouraging...