A5060037212- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Assays
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Heart Rate Variability and Autonomic Control
- Adrenal Hormones and Disorders
- Heart Failure Treatment and Management
- Insects and Parasite Interactions
- Glycogen Storage Diseases and Myoclonus
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Urticaria and Related Conditions
- Pharmacological Effects and Toxicity Studies
- Anesthesia and Pain Management
- Pediatric health and respiratory diseases
Ninewells Hospital
2015-2022
University of Dundee
2015-2022
Edinburgh Royal Infirmary
2021-2022
Cleveland Research (United States)
1992
BackgroundMany repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is nafamostat mesylate.MethodsWe present the findings a phase Ib/IIa open label, platform randomised controlled trial intravenous hospitalised patients with confirmed COVID-19 pneumonitis. Patients were assigned randomly standard care (SoC), or an alternative therapy. Nafamostat was administered as...
Airway hyperresponsiveness (AHR) and eosinophilia are hallmarks of persistent asthma.We investigated whether eosinophil depletion with benralizumab might attenuate indirect mannitol AHR in severe uncontrolled asthma using a pragmatic open-label design.After 4-week run-in period provision usual inhaled corticosteroids and/or long-acting β-agonist (baseline), adults mannitol-responsive eosinophilic received 3 doses 30 mg every 4 weeks, followed by 16 weeks' washout after the last dose. The...
The forced oscillation technique (FOT) measures respiratory impedance during normal tidal breathing and requires minimal patient cooperation.To compare IOS AOS devices in patients with asthma COPD.We compared two different FOT devices, namely impulse oscillometry using a loudspeaker (IOS: Jaeger Masterscreen) airwave vibrating mesh (AOS: Thorasys Tremoflo) for pre- post-bronchodilator measurements 84 COPD.The overall pattern of measurement bias was higher resistance reactance AOS, this being...
Summary Permanent paraplegia following coeliac plexus block has been reported on several occasions. We report a case of reversible block.
Abstract Background Smoking worsens underlying asthma inflammation and also induces resistance to inhaled corticosteroids (ICS). Small airways dysfunction measured by impulse oscillometry (IOS) is associated with worse control. Objectives We investigated the effects on small of adding long‐acting beta‐agonist (LABA) alone or muscarinic antagonist (LAMA) ICS in asthmatic smokers. Methods Sixteen current smokers were enrolled: mean age 44 year, FEV1 84%, FEF25‐75 47%, R5 158%, ACQ 1.69, 20...
Beta-blockers remain underused in patients with chronic obstructive pulmonary disease (COPD) and cardiovascular disease.We compared how different inhaled therapies affect tolerability of bisoprolol carvedilol moderate to severe COPD.A randomized, open label, cross-over study.We the cardiopulmonary interactions 5 mg qd or 12.5 bid for 6 weeks conjunction with: (i) triple: corticosteroid/long acting beta-agonist/long muscarinic antagonist (ICS + LABA LAMA), (ii) dual: ICS (iii) alone.Eighteen...
Tiotropium is a long acting muscarinic antagonist (LAMA), licensed as triple therapy with inhaled corticosteroid and long-acting beta-agonist (ICS/LABA). There may be synergistic benefit between LAMA LABA consequence of receptor cross-talk, which in turn could modify beta-2 downregulation associated tolerance induced by LABA.We hypothesize this mechanism result reduction airway hyperresponsiveness (AHR) when using therapy.We evaluated 14 non-smoking asthmatics an open-label, randomized...
To demonstrate the noninferiority of extrafine beclomethasone/formoterol fumarate (BDP/FF) dry powder inhaler (DPI) vs. BDP/FF pressurized metered dose (pMDI; Foster® 100/6 μg NEXThaler and pMDI, respectively) in onset reliever effect after methacholine induced bronchospasm asthmatic patients, evaluated terms forced expiratory volume 1 s (FEV1 ) at 5 min postdose. The DPI provides an alternative device option for patients who cannot use a pMDI properly during acute asthma attack.Sixty-five...
We evaluated whether Gly16Arg beta2-receptor genotype relates to impulse oscillometry (IOS) in a real-life clinic setting. Patients with persistent asthma taking inhaled corticosteroid ± long-acting beta-agonist (ICS LABA) were evaluated. compared groups comprising either no Arg copies (i.e. GlyGly) versus one or two ArgArg ArgGly). IOS outcomes included total airway resistance at 5 Hz (R5), central 20 (R20), peripheral (R5–R20), reactance Hz, area under curve (AX) and resonant frequency...
Little is known about impulse oscillometry (IOS) in COPD. IOS an effort independent measure of lung resistance and reactance (compliance). We assessed how frequency dependence (R) (X) changed response to bronchoconstriction with carvedilol followed by long acting beta-agonist (LABA) withdrawal. N = 12 patients moderate severe COPD were analysed, who had ≥ 100 ml fall FEV1 carvedilol. Compared baseline taking ICS/LABA there 21, 59, 135% significant changes at 5 Hz (R5), (X5), area (AX),...