Andrew Duncan
A5049527547- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Peripheral Artery Disease Management
- Long-Term Effects of COVID-19
- Diabetic Foot Ulcer Assessment and Management
- Venous Thromboembolism Diagnosis and Management
- Computational Drug Discovery Methods
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
- Cardiac pacing and defibrillation studies
- Cellular Automata and Applications
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Vaccine Coverage and Hesitancy
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Kawasaki Disease and Coronary Complications
- Pharmacological Receptor Mechanisms and Effects
- COVID-19 Impact on Reproduction
- Poisoning and overdose treatments
- Pressure Ulcer Prevention and Management
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Delphi Technique in Research
- Heparin-Induced Thrombocytopenia and Thrombosis
Mater Misericordiae University Hospital
2023-2024
NHS Lothian
2021-2022
University of Dundee
2021
Medical Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
Public Health Scotland
2021
University Hospitals Birmingham NHS Foundation Trust
2021
Trinity College Dublin
2021
Nepal Health Research Council
2021
BackgroundMany repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is nafamostat mesylate.MethodsWe present the findings a phase Ib/IIa open label, platform randomised controlled trial intravenous hospitalised patients with confirmed COVID-19 pneumonitis. Patients were assigned randomly standard care (SoC), or an alternative therapy. Nafamostat was administered as...
Objectives To describe the incidence of adverse events (AEs), reactogenicity symptoms, menstrual changes and overall self-rated improvement in health well-being after COVID-19 vaccination. Design VAC4COVID is an ongoing prospective, active observational, post-authorisation cohort safety study (PASS) UK-approved vaccines for disease. Setting The conducted through a secure website ( www.vac4covid.com ) by MEMO Research, University Dundee, UK. Participants 16 265 adult (18 years or older) UK...
Objectives Venous thromboembolism is a potentially fatal complication of superficial endovenous treatment. Proper risk assessment and thromboprophylaxis could mitigate this hazard; however, there are currently no evidence-based or consensus guidelines. This study surveyed UK Republic Ireland vascular consultants to determine areas consensus. Methods A 32-item survey was sent via the Vascular Endovascular Research Network (phase 1). These results generated 10 statements which were...
Introduction Patients with peripheral arterial disease (PAD), aneurysmal (AD) or carotid atherosclerosis are at high cardiovascular risk, necessitating secondary protection. The aim of this study was to determine compliance risk reduction guidelines in new patients referred vascular clinics. Methods A multicentre collaborative national observational audit eight tertiary general clinics over a three-month period England and Wales conducted by the Vascular Endovascular Research Network (VERN)....
Abstract Objectives to establish and quantify any observable association between the exposure community prescriptions for quinine acute kidney injury (AKI) events in a population of older adults. Design two observational studies using same dataset, retrospective longitudinal cohort study self-controlled case series (SCCS). Setting NHS health board Scotland. Participants adults (60+ years) who received Tayside, Scotland, January 2004 December 2015. The first included 12,744 individuals. SCCS...
While venous thromboembolism (VTE) is a well recognised occurrence in clinical practice the developed world, with event rates of at least 2-3 million per year, little attention paid to this entity developing world where burden infectious diseases and limited access care have not VTE as significant cause morbidity mortality. The opportunity for Africa do better inevitable recognition consequence becomes more apparent available using basic tools therapies.
Background: Living in deprived areas is associated with poorer outcomes after certain vascular procedures and surgical site infection other specialties. Our primary objective was to determine whether living more income-deprived groin wound arterial intervention. Secondary objectives were mortality clinical consequences of infection. Methods: Postal code data for patients from the United Kingdom who included Groin Wound Infection Vascular Exposure (GIVE) multicenter cohort study used income...
Abstract Background Fractional flow reserve (FFR) is a diagnostic gold standard in the functional assessment of coronary artery stenoses (1). Alternative invasive and non-invasive methods have been developed an attempt to avoid limitations associated with FFR including added procedural risk, patient discomfort, time cost. Vessel fractional (vFFR) novel software using two angiographic projections generate 3D vessel reconstruction which has shown high accuracy predicting positive (2-4)....
ABSTRACT Despite the success of vaccines and selected repurposed treatments, COVID-19 is likely to remain a global health problem further chemotherapeutics are required. Many drugs have progressed rapidly Phase 2 3 trials without characterisation Pharmacokinetics (PK)/Pharmacodynamics (PD) including safety in COVID-19. One such drug Nafamostat Mesylate (Nafamostat), synthetic serine protease inhibitor with anticoagulant anti-inflammatory properties. Preclinical data has demonstrated that it...
Background: Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is Nafamostat Mesylate.Methods: We present the findings a phase Ib/II open label, platform randomised controlled trial intravenous hospitalised patients with confirmed COVID-19 pneumonitis. Patients were assigned randomly standard care (SoC), or an alternative therapy. was administered as infusion at...