A5101792092- Neuroendocrine regulation and behavior
- Spine and Intervertebral Disc Pathology
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Sexual function and dysfunction studies
- Radiopharmaceutical Chemistry and Applications
- Respiratory and Cough-Related Research
- Biomedical and Chemical Research
- Medical Imaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Musculoskeletal Disorders and Rehabilitation
- Chemical Reactions and Isotopes
- Health and Medical Studies
- Orthopedic Infections and Treatments
- Immune Cell Function and Interaction
- Neuroendocrine Tumor Research Advances
- Hip disorders and treatments
- Stress Responses and Cortisol
- Helicobacter pylori-related gastroenterology studies
- Respiratory viral infections research
- Medical Practices and Rehabilitation
- Metabolomics and Mass Spectrometry Studies
- Helminth infection and control
- Psychology, Coaching, and Therapy
- Dermatological diseases and infestations
Hammersmith Medicines Research
2014-2022
Hammersmith Hospital
2021
Invicro (United Kingdom)
2020-2021
Imperial College London
2020-2021
Central Middlesex Hospital
2014
Internationale Akademie Berlin
2011
University of Copenhagen
2008
Tauern Hospital Zell am See
2007
HeidelbergCement (United States)
2002
Leiden University
1998
Abstract GSK3389404 is a liver‐targeted antisense oligonucleotide that inhibits synthesis of hepatitis B surface antigen and all other virus proteins. This first‐in‐human, randomized, double‐blind, phase 1 study assessed the safety pharmacokinetics administered subcutaneously (SC) in healthy subjects. Four single ascending‐dose cohorts (10 mg, 30 60 120 mg) 3 multiple (30 mg once weekly for 4 weeks) each comprised 6 subjects randomized to 2 placebo. There were no serious adverse events (AEs)...
Aims Emodepside is an anthelmintic, originally developed for veterinary use. We investigated in healthy subjects the safety, and pharmacokinetics of a liquid service formulation (LSF) immediate release (IR) tablet emodepside 2 randomised, parallel‐group, placebo‐controlled, Phase I studies. Methods Seventy‐nine 10 cohorts single ascending dose study 24 3 ascending‐dose multiple were enrolled. as LSF was administered orally 1–40‐mg doses days 5 or mg once daily 10‐mg twice doses,...
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung condition, causing progressive decline in function leading to premature death. Acute exacerbations COPD patients are predominantly associated with respiratory viruses. Ribavirin a generic broad-spectrum antiviral agent that could be used for treatment of viral infections COPD. Using the Particle Replication In Nonwetting Templates (PRINT) technology, which produces dry-powder particles uniform shape and size, two new...
To compare gastric acid suppression by netazepide, a gastrin/CCK2 receptor antagonist, with that proton pump inhibitor (PPI), and to determine if netazepide can prevent the trophic effects of PPI-induced hypergastrinaemia.Thirty healthy subjects completed double-blind, randomized, parallel group trial oral rabeprazole, alone combined, once daily for 6 weeks. Primary end points were: basal pentagastrin-stimulated 24 h circulating gastrin chromogranin A (CgA) at baseline, start treatment,...
Abstract Context SJX-653 is a novel neurokinin 3 receptor (NK3R) antagonist. The NK3 pathway central regulator of gonadotropin releasing hormone (GnRH) secretion and has also been implicated in the generation hot flashes. Therefore, decreases luteinizing (LH) testosterone men serve as sensitive pharmacodynamic (PD) markers antagonism. Objective To characterize safety, tolerability, pharmacokinetics, activity healthy men. Design A randomized, placebo-controlled, double-blind, single ascending...
Abstract Daprodustat, an oral hypoxia‐inducible factor prolyl hydroxylase inhibitor, is being investigated for treatment of anemia in chronic kidney disease. This phase 1, nonrandomized, 2‐period, crossover study 6 healthy men characterized the absorption, distribution, and excretion daprodustat when administered as intravenous (IV) doses unlabeled radiolabeled ([ 14 C]‐GSK1278863). Tolerability pharmacokinetic properties daprodustat, its metabolites systemic circulation, were also...
Abstract Inhaled batefenterol is an investigational bifunctional molecule for the treatment of chronic obstructive pulmonary disease. The excretion balance and pharmacokinetics using [ 14 C]‐radiolabeled drug administered orally as intravenous (IV) infusion were assessed. In this 2‐period, open‐label study, 6 healthy male subjects received a single IV microtracer 1‐hour 4 μg C]‐batefenterol concomitant with inhaled nonradiolabeled (1200 μg) followed by oral (200 in period 2 after 14‐day...
Emulsified formulations of omega-3 fatty acids may increase plasma concentrations docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) compared with non-emulsified formulations. The current study evaluated DHA + EPA as well individually following administration emulsified vs cod liver oil formulations.In this randomized, 2-period, crossover (ClinicalTrials.gov NCT02428699), 47 healthy adults received single doses an formulation a formulation, each containing 10% plus closely matched...
To demonstrate the noninferiority of extrafine beclomethasone/formoterol fumarate (BDP/FF) dry powder inhaler (DPI) vs. BDP/FF pressurized metered dose (pMDI; Foster® 100/6 μg NEXThaler and pMDI, respectively) in onset reliever effect after methacholine induced bronchospasm asthmatic patients, evaluated terms forced expiratory volume 1 s (FEV1 ) at 5 min postdose. The DPI provides an alternative device option for patients who cannot use a pMDI properly during acute asthma attack.Sixty-five...
e14007 Background: Bevacizumab is a recombinant humanized monoclonal antibody that binds selectively to vascular endothelial growth factor-A (VEGF-A). was first approved for treatment of metastatic colon cancer under the brand name Avastin; it has since been treating various other cancers. FKB238 being developed as biosimilar Avastin. In this first-in-human study, safety, pharmacokinetics (PK) and immunogenicity were compared those branded Avastin from US EU market. Methods: Ninety nine...
Das Ziel dieser Studie war es, mögliche Mitursachen einer solchen Diagnoseverzögerung herauszufinden, und den Anteil von Patient, Hausarzt Gynäkologe zu untersuchen. Ein online-Fragebogen wurde ausgefüllt 320 Frauen mit der Diagnose Endometriose. Es eine durchschnittliche 13,9 (+/- 8,4) Jahren gefunden. Hierbei für die Patientinnen mittlere Diagnoselatenz (PD) 7,2 7,8) Jahren, Hausärzte Latenz (GPD) 3,8 (+/-6,3) Gynäkologen Verzögerung (GD) 2,2 4,1) berechnet. Eine signifikante Korrelation...