A5057311195- Exercise and Physiological Responses
- Cell Adhesion Molecules Research
- Kidney Stones and Urolithiasis Treatments
- Corneal Surgery and Treatments
- Renal and related cancers
- Cardiovascular and exercise physiology
- Protease and Inhibitor Mechanisms
- Chronic Kidney Disease and Diabetes
- Ion Transport and Channel Regulation
- Renal Diseases and Glomerulopathies
- Drug Transport and Resistance Mechanisms
- Hepatitis B Virus Studies
- Periodontal Regeneration and Treatments
- Immune Cell Function and Interaction
- DNA and Nucleic Acid Chemistry
- Muscle metabolism and nutrition
- Retinoids in leukemia and cellular processes
- Aquaculture Nutrition and Growth
- Ion channel regulation and function
- Proteoglycans and glycosaminoglycans research
- Hormonal and reproductive studies
- Physical Education and Training Studies
- Cancer Immunotherapy and Biomarkers
- Drug-Induced Adverse Reactions
- Pharmacological Effects and Assays
University of Zurich
2019-2023
Czech Academy of Sciences, Institute of Physiology
2022
Université Laval
2009-2015
Hôpital du Saint-Sacrement
2013
University of South Carolina
2005-2012
North Carolina State University
1995
The University of Texas Medical Branch at Galveston
1995
Peking University
1995
Institute of Chemistry
1995
Significance Statement A novel disease phenotype comprises a tubulopathy with severe hypokalemia, renal salt wasting, disturbed acid-base homeostasis, and sensorineural deafness associated variants in KCNJ16 (K ir 5.1). In the kidney, inwardly rectifying potassium channel subunit forms functional heteromers KCNJ10 distal nephron KCNJ15 proximal tubule. Functional studies of mutant Xenopus oocytes demonstrate function complexes both KCNJ15. Individuals may present metabolic acidosis or...
Abstract Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of mammalian kidney. It most abundant normal urine. Defective uromodulin processing associated with various kidney disorders. The luminal release and subsequent polymerization depend on its cleavage mediated by serine protease hepsin. biological relevance proper remains unknown. Here we combined vivo testing hepsin-deficient mice, ex analyses isolated tubules vitro studies TAL cells to...
The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that inhibitor prescribers must be aware electrolytic disorders since dysfunction can precede serum creatinine increase and reveal renal toxicity.
Abstract Missense mutations in the uromodulin ( UMOD ) gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD), one of most common monogenic diseases. The unknown impact allelic and dosage effects fate mutant leaves open gap between postulated gain‐of‐function mutations, end‐organ damage progression ADTKD. Based on two prevalent missense with divergent progression, we generated Umod C171Y R186S knock‐in mice that showed strong aggregates activation ER stress unfolded protein...
Purpose: The early step of corneal wound healing is characterized by the massive production fibronectin (FN), whose secretion progressively replaced collagens from basal membrane as proceeds. Here, we examined whether expression gene encoding α5 subunit FN-binding integrin α5β1 changes epithelial cells (CECs) are cultured in presence collagen type I (CI) or IV (CIV). Methods: Responsiveness toward was determined transfection promoter/chloramphenicol acetyltransferase (CAT) plasmids into...
We examined the possible negative interaction of combined use NSAID indomethacin (IND) and exercise in mice. Mice were assigned to one 4 groups: Exercise 2.5 mg/kg IND (Ex-2.5), Sedentary (Sed-2.5), 5.0 (Ex-5.0) (Sed-5.0). given (gavage) 1 h prior (treadmill run at 30 m/min, 8% grade for 90 min) or rest 14 consecutive days. Run times, body weight mortality recorded daily. Sed-5.0 was highly toxic caused 70% compared Sed-2.5, which well tolerated (0% mortality) (P<0.05). While addition had no...
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by athletes to reduce or prevent exercise-induced inflammation and pain. NSAID use however, has been linked various side effects including mucosal damage in the gastrointestinal tract (GI). Stressful exercise can also cause GI distress increased permeability that allow translocation of gut bacteria blood (endotoxemia). We hypothesized combined could contribute exaggerated fatigue potentially lethal conditions such as endotoxic...
Exhaustive exercise has been associated with increased risk for respiratory infection. Oat β-glucan (OβG), a soluble fiber mild immunostimulant activity, can offset the decrease in macrophage (MΦ) antiviral resistance and of infection stress. PURPOSE To determine role lung MΦs on benefits OβG susceptibility to following METHODS Exercise mice were run fatigue treadmill 3 consecutive days prior was fed drinking water 10 Mice administered 100μl clodronate (Ex-H2O-CL2MDP, Ex-OβG-CL2MDP,...
Exhaustive exercise has been associated with increased risk for respiratory infection. Oat β-glucan (OβG), a soluble fiber mild immunostimulant activity, can offset the decrease in macrophage (MΦ) antiviral resistance and of infection stress. PURPOSE To determine role lung MΦs on benefits OβG susceptibility to following METHODS Exercise mice were run fatigue treadmill 3 consecutive days prior was fed drinking water 10 Mice administered 100μl clodronate (Ex-H2O-CL2MDP, Ex-OβG-CL2MDP,...
Abstract Missense mutations in the UMOD gene encoding uromodulin cause autosomal dominant tubulointerstitial kidney disease (ADTKD), one of most common monogenic diseases. A pressing need for ADTKD is to bridge gap between postulated gain-of-function and organ damage - a prerequisite therapeutic development. Based on two missense associated with divergent progression ADTKD, we generated Umod C171Y R186S knock-in mice that showed strong allelic dosage effects, distinct dynamic pathways...