A5070130196- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Digestive system and related health
- DNA and Nucleic Acid Chemistry
- Erythrocyte Function and Pathophysiology
- Enzyme Structure and Function
- Forensic Toxicology and Drug Analysis
- Health, Nursing, Elderly Care
- Psychedelics and Drug Studies
- Protein Structure and Dynamics
- Healthcare during COVID-19 Pandemic
- Cannabis and Cannabinoid Research
- Language Acquisition and Education
- Science and Education Research
- Youth, Drugs, and Violence
- Phytochemistry Medicinal Plant Applications
- Drug Transport and Resistance Mechanisms
- Balance, Gait, and Falls Prevention
- Sports Performance and Training
- Pharmacological Effects of Medicinal Plants
- Indigenous Health and Education
- Brazilian cultural history and politics
- Molecular Sensors and Ion Detection
Medical University of Vienna
2022-2025
Al-Ahliyya Amman University
2024
Faculdade de Ciências Médicas de Minas Gerais
2024
Institute of Pharmacology
2024
Escola Superior de Ciências da Saúde
2022
Advanced Network and Services (United States)
2022
Universidade Federal de Uberlândia
2013-2020
Universidade Estadual de Londrina
2018
Universidade Federal do Paraná
2017
Universidade Federal de São Paulo
2014
Abstract The presynaptic serotonin transporter (SERT) clears extracellular following vesicular release to ensure temporal and spatial regulation of serotonergic signalling neurotransmitter homeostasis. Prescription drugs used treat neurobehavioral disorders, including depression, anxiety, obsessive-compulsive disorder, trap SERT by blocking the transport cycle. In contrast, illicit abuse like amphetamines reverse directionality, causing efflux. Both processes result in increased levels. By...
<title>Abstract</title> SbmA is a membrane transporter from <italic>Escherichia coli</italic> that imports antimicrobial peptides. Although the protein secondary energized by proton gradient, it structurally related to transmembrane domain (TMD) of ATP-binding cassette (ABC) transporters. therefore bridges structural divide between primary and However, remained unclear, if also shares mechanism alternating access with ABC transporters, because only single (outward-open) state has been...
The human GABA transporter (GAT1) is a membrane that mediates the reuptake of neurotransmitter from synaptic cleft into neurons and glial cells. Dysregulation transport cycle has been associated with epilepsy neuropsychiatric disorders, highlighting crucial role in maintaining homeostasis brain levels. GAT1 secondary active couples movement substrate to simultaneous sodium chloride ions along their electrochemical gradients. Using MD simulations, we identified novel recruiting site at...
The serotonin transporter (SERT) is a member of the Solute Carrier 6 (SLC6) family and responsible for maintaining appropriate level in brain. Dysfunction SERT has been linked to several neuropsychiatric disorders, including depression, anxiety obsessive-compulsive disorder. Therefore, an in-depth understanding mechanism on atomistic level, coupled with quantification dynamics associated free energies required. Here, we constructed Markov state models (MSMs) from extensive unbiased molecular...
Abstract The interaction between two nitrosyl ruthenium complexes [Ru (NH.NHq–COOH)(tpy)NO](PF 6 ) 3 (RuBDQ) and (NH.NHq–H)(tpy)NO](PF (RuBD) human serum albumin (HSA) was investigated using spectroscopic computational methods. From fluorescence experiments, a dynamic quenching mechanism binding constants at single site demonstrated the higher stability of RuBDQ–HSA system 308 K compared with RuBD–HSA. Thermodynamic parameters indicated that RuBDQ RuBD to HSA mainly driven by hydrophobic...
3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is re-emerging in clinical settings as a candidate for the treatment of specific neuropsychiatric disorders (e.g. post-traumatic stress disorder) combination with psychotherapy. MDMA psychoactive drug, typically regarded an empathogen or entactogen, which leads to transporter-mediated monoamine release. Despite its therapeutic potential, can induce dose-, individual-, and context-dependent untoward effects outside safe settings. In this...
Abstract The presynaptic serotonin (5HT) transporter (SERT) clears extracellular 5HT following vesicular release to ensure temporal and spatial regulation of serotonergic signalling neurotransmitter homeostasis. Clinically approved drugs used for the treatment neurobehavioral disorders, including depression, anxiety, obsessive-compulsive disorder that target SERT trap in outward-open state thus blocking transport cycle. In contrast, illicit abuse like amphetamines reverses directionality,...
The human GABA transporter (GAT1) is a membrane that mediates the reuptake of neurotransmitter from synaptic cleft into neurons and glial cells. Dysregulation transport cycle has been associated with epilepsy neuropsychiatric disorders, highlighting crucial role in maintaining homeostasis brain levels. GAT1 secondary active couples movement substrate to simultaneous sodium chloride ions along their electrochemical gradients. Using MD simulations, we identified novel recruiting site at...
INTRODUÇÃO: O consumo de leite e produtos lácteos tem sido objeto estudo em diversas áreas da saúde nutrição, dada sua importância na dieta humana os potenciais impactos saúde. Esta revisão abordou adaptações genéticas para a persistência lactase, influências culturais domesticação animais leiteiros o leite, além dos efeitos do saúde, considerando doenças metabólicas, tolerância à lactose, entre outros aspectos. METODOLOGIA: Revisão narrativa literatura realizada partir busca bibliográfica...
Abstract 3,4-Methylenedioxymethamphetamine (MDMA, ‘ ecstasy’ ) is re-emerging in clinical settings as a candidate for the treatment of specific psychiatric disorders (e.g. post-traumatic stress disorder) combination with psychotherapy. MDMA psychoactive drug, typically regarded an empathogen or entactogen, which leads to transporter-mediated monoamine release. Despite its therapeutic potential, can induce dose-, individual-, and context-dependent untoward effects outside safe settings. In...
The human GABA transporter (GAT1) is a membrane that mediates the reuptake of neurotransmitter from synaptic cleft into neurons and glial cells. Dysregulation transport cycle has been associated with epilepsy neuropsychiatric disorders, highlighting crucial role in maintaining homeostasis brain levels. GAT1 secondary active couples movement substrate to simultaneous sodium chloride ions along their electrochemical gradients. Using MD simulations, we identified novel recruiting site at...
The human GABA transporter (GAT1) is a membrane that mediates the reuptake of neurotransmitter from synaptic cleft into neurons and glial cells. Dysregulation transport cycle has been associated with epilepsy neuropsychiatric disorders, highlighting crucial role in maintaining homeostasis brain levels. GAT1 secondary active couples movement substrate to simultaneous sodium chloride ions along their electrochemical gradients. Using MD simulations, we identified novel recruiting site at...
If $K\subset\mathbb{R}^n$ is a convex body and $\Gamma_pK$ the $p$-centroid of $K$, $L_p$ Busemann-Petty centroid inequality states that $\vol(\Gamma_pK) \geq \vol(K)$, with equality if only $K$ an ellipsoid centered at origin. In this work, we prove inequalities for type functional $r$-mixed volume $1 \leq r < n$, establish as consequence, version inequality. \keywords{Convex body, Moment centroid} }
Introdução a música e sua apreciação por grande parte da população já é conhecida. no entanto, âmbito das ciências saúde ainda não tão difundida nem do conhecimento de muitos. Ainda assim, tem estabelecido marca nesta área. presente trabalho música, associada à construção narrativas vida, faz-se como um recurso processo cuidado humanização ambiente hospitalar uma terapia propriamente dita. atuação apoia-se reconhecimento importância levar em conta integralidade, incluindo aspectos história...
The availabity of water is a major determinant life quality, preventing diseases and promoting health. However, modern society development model has compromised most resources. Thus, monitoring drinking quality an important strategy to protect human Our objective was investigate waterborne incidence in large slum area, where new sanitation infrastructures were installed. study area 3 km2, almost 40,000 people live. We collected 476 samples from 235 households, health units 12 schools this...