Diagnosis of Adrenal Insufficiency (AI) in children is often challenging due to the relatively low incidence and non-specific presentation, so misdiagnosis occurs, especially emergency settings. Prompt recognition management are crucial reducing morbidity mortality linked this potentially fatal illness, emphasizing importance heightened awareness among healthcare professionals. A 9-month-old girl was brought ER with a chief complaint excessive vomiting. The presented hyperpigmentation,...

Hyperglycemic Hyperosmolar State (HHS) is a triad characterized by severe hyperglycemia, significantly increased serum osmolality, and dehydration without marked ketoacidosis. It occurs in patients with both Type 1 2 Diabetes Mellitus. This case report discusses 7-year 9-month-old girl who presented to the hospital shortness of breath acidosis evidence ketonemia. The patient was moderately malnourished had experienced urinary frequency over past month. On examination, she alert but dry...

The coronavirus-19 (COVID-19) pandemic requires the use of online media to ensure monitoring type 1 diabetes mellitus (T1DM) in children. Thus, this study aims determine whether education effectively improves quality life (QoL) children with T1DM during pandemic.The study, conducted from March October 2020, utilized paired t-test before and after education. Moreover, it adopts recommended Pediatric Quality Life Inventory (PedsQL) 3.2 module for 33 patients registered Endocrine Outpatient...

Type 1 diabetes mellitus (T1DM) is disease caused by the destruction of β pancreatic cells. The activation T-lymphocyte and proliferation inhibitor are induced protein tyrosine phosphatase non-receptor type 22 (PTPN22). However, link between PTPN22 C1858T gene polymorphism T1DM still controversy. This study aimed to analyse in Indonesian children with T1DM.This case-control was conducted from March 2021 May 2022 Endocrinology Outpatient Clinic at Dr. Soetomo Hospital Tropical Disease Center...

Type 1 diabetes (T1D) is an organ-specific autoimmune disease related to the response against pancreatic β-cells. Zinc transporter 8 (ZnT8), islet-specific gene product localized β-cell insulin granule, was recently identified as autoantigen in T1D.To evaluate use of ZnT8 autoantibody (ZnT8A) for diagnosing T1D.This case-control study conducted at Dr. Soetomo General Hospital, Surabaya, Indonesia, from March May 2019. Children younger than 18 years age with T1D based on International Society...

Background: Type 1 diabetes mellitus (T1DM) is the most common chronic disease in children, with several severe short and long-term complications. Glycemic control an important aspect of management influential factor being compliance self-monitoring blood glucose (SMBG). Mostly, Indonesia, finger stick devices as a monitoring tool were frequently used. About 20% children follow recommendation to measure four six times daily. Methods: This single center, cross-sectional study that was...

More than 40 genes influence the progression of type 1 diabetes mellitus (T1DM), including human leukocyte antigen (HLA) alleles. Different HLA genotype patterns result in diverse rates T1DM development. class II DR, DQ, and DP vary among different populations ethnicities. Data on polymorphism Indonesia are lacking. Therefore, this study was designed to evaluate gene HLA-DQA1 HLA-DQB1 Indonesian children with T1DM.

CTLA-4 gene polymorphism plays an important role in children with type 1 diabetes mellitus (T1DM). However, data on this subject vary among different races and ethnics.To analyze CT-60 A/G 1822 C/T T1DM compared to control.The using polymerase chain reaction-restriction fragment length 25 controls. The inclusion criteria were patients regularly controlled at the Pediatric Endocrine Outpatient Clinic of Dr. Soetomo Hospital, aged 4-18 years willing join study exclusion hospitalized pediatric...

Treatment with antiseizure medications (ASMs) for more than 6 months requires monitoring of side effects, one which is a decreased level serum vitamin D. This study aimed to compare the influence therapies versus multiple ASMs on 25-hydroxy D (25-OHD) levels among children epilepsy.Our cross-sectional comparative was conducted in Paediatric Neurology Clinic at Soetomo Academic Hospital. Epileptic aged 2-18 years who had been using least were enrolled and grouped according whether they taking...

Background Diabetic ketoacidosis (DKA) is a complication of type I diabetic mellitus (TIDM). Early recognition and prompt treatment can reduce mortality. Objective To evaluate the profiles patients with ketoasidosis in Dr. Soetomo Hospital, Surabaya, Indonesia. Methods Retrospective medical records admitted to pediatric intensive care unit DKA Indonesia from January 2002 June 2013 were reviewed. The data collected included clinical parameters, laboratory imaging results, predisposing...

Currently, the development of acne drugs (antiacne) use many natural materials because can minimize side effect if compared with synthetic chemicals drugs. Acne caused by propionibacterium acnes, staphylococcus epidermis and aureu. One plants that be used for treatment is leaves Avocado (Persea americana Mill). The aim this study was to know whether ethanol extract avocado Mill.) made into an ointment preparations fulfill requirements. Sample in research which maceration method. formulations...

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BackgroundDiabetic ketoacidosis (DKA) is a complication of type I diabetic mellitus (TIDM).Early recognition and prompt treatment can reduce mortality.Objective To evaluate the profiles patients with ketoasidosis in Dr. Soetomo Hospital, Surabaya, Indonesia.Methods Retrospective medical records admitted to pediatric intensive care unit DKA Indonesia from January 2002 June 2013 were reviewed.The data collected included clinical parameters, laboratory imaging results, predisposing factors,...

Thyroid dysfunction is the most common endocrine disorder in Down syndrome (DS) children. Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) one of immune regulatory genes that correlates with Hashimoto's thyroiditis (HT). However, studies on CTLA-4 +49A/G DS children HT are still limited. We aimed to evaluate gene polymorphism HT. This case-control study, conducted from February 2020 2022 at Dr. Soetomo General Hospital, Surabaya, enrolled 40 and 50 healthy The DNA sequencing was...

Background: Type 1 Diabetes Mellitus (T1DM) is a chronic disease that requires complicated therapies. The coronavirus 2019 (COVID-19) pandemic has caused lockdown restrictions, compromising access to medical care, including T1DM management. Poor medication adherence may affect the quality of life (QoL) and glycemic control. Objectives: This study analyzed association among QoL, adherence, control in patients during COVID-19 pandemic. Methods: recruited aged 5 - 18 who regularly visited...

Children with Down syndrome (DS) are prone to developing autoimmune thyroid disease (AITD). Previous studies found lower selenium (Se) levels in children AITD. Glutathione peroxidase-3 (GPx3) and selenoprotein-P (SePP) widely used measure Se levels. DS tend have levels, the main contributor hypothyroidism this population. This study aimed analyze Se's role AITD Indonesian DS.This cross-sectional was conducted between February 2021-June 2022 at Pediatric Outpatient Clinic of Dr Soetomo...

Chronic Kidney Disease (CKD) is a serious disease in children with increasing prevalens over the years. Sustained pain and uncertainty for recovery mostly leads to certain mental condition, such as depression anxiety. This condition also usually affected caregiver CKD. study will discuss about quality of life The aim this systematic review determine CKD factors associated CKD.There are 4 studies used was conducted through PubMed database. number inclusion that be discussed consists 2...

Background : Vitamin D and calcium have metabolic functions in the cells insufficient intake has been proven to increase risk factor for many chronic diseases, such as diabetes mellitus. both contribute raising insulin secretion by regulating extracelullar concentration fluxing through cell membranes facilitated calcium-sensing receptor. This study aimed determine correlation between vitamin with blood glucose levels obese woman aged 45-55 years.Methods Observational cross sectional design....

This study aims to determine the relationship between length of illness and quality life people with Type 1 Diabetes Mellitus during COVID-19 pandemic. research is an analytical description a cross-sectional approach using questionnaire telephone interview techniques. The in this was based on several guidelines previous research. Measurements PedsQl 3.2 Module. Data were collected validated consisting 33 question items. data October 2020. A total questionnaires successfully distributed...

Background: Sleep is essential for growth, development, and health, with inadequate sleep linked to risks such as obesity, hypertension, mood disorders. patterns differ by sex, females often experiencing poorer quality greater susceptibility disturbances due factors like the menstrual cycle. Adolescents, particularly boarding students, face unique challenges from academic extracurricular demands, potentially impacting growth. This study aimed at studying relationship between height within...

Purpose: This study aims to examine the relationship between early puberty onset and childhood dietary patterns in Indonesian adolescents, as well effects of nutritional factors including obesity, on pubertal disorders. Approach, methodology, design: Eighty-five sixth-graders participated a non-randomized intervention trial at Elementary School Muhammadiyah 16 Surabaya. Pediatricians conducted seminars that provided participants with information regarding puberty. The data was analyzed using...

Type 1 diabetes mellitus (T1DM) is a lifelong disorder that affects all aspects of the lives children and their families. A Health Needs Assessment (HNA) survey was conducted at two camps in Batu, East Java, Parung, West to evaluate challenges burdens faced by families living with T1DM Indonesia. total forty-one respondents, comprising parents/caregivers, participated HNA. Most respondents had pay for diabetes-related expenses, such as insulin (31.7%), self-monitoring blood glucose needles...

Introduction: Healthy diet is essential for healthy development as well growth. The focus of nutritional evaluation in children to recognize and avoid conditions such malnutrition obesity, addition the associated rise mortality morbidity. This study aims describe dietary intake nutrition status junior high school students. Methods: cross-sectional was conducted from Mei – August 2024 involved aged 12-15 years old at private school. General information collected by questionnaire....